Ingrid Safina,Luke T Childress,Srinivas R Myneni et al.
Ingrid Safina et al.
Over the years, conventional skin grafts, such as full-thickness, split-thickness, and pre-sterilized grafts from human or animal sources, have been at the forefront of skin wound care. However, these conventional grafts are associated with...
GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review [0.03%]
GSTM1和GSTT1多态性在健康志愿者中的分布-全球系统回顾
Giovana Nakanishi,Laísa S Bertagnolli,Murilo Pita-Oliveira et al.
Giovana Nakanishi et al.
The GSTM1 and GSTT1 genes encode homonymous enzymes, which are responsible for the detoxification of several substances potentially harmful to the human body, such as air pollution, drugs, pesticides, and tobacco. However, some individuals ...
Magomed Khaidakov,Valeria Troshina,Dmitry Menglet et al.
Magomed Khaidakov et al.
Gerontological research has accelerated dramatically in the last few decades. However, despite increased public interest, federal funding, an army of researchers, and many notable discoveries and high-impact publications, the goal of achiev...
Mass spectrometry based protein biomarkers and drug target discovery and clinical diagnosis in Age-Related progressing neurodegenerative diseases [0.03%]
基于质谱技术的蛋白质生物标志物及药物靶点在年龄相关神经退行性疾病发展进程中的发现与临床诊断研究
Ishita Agrawal,Pallavi Tripathi,Shyamasri Biswas
Ishita Agrawal
Neurodegenerative diseases correspond to overly complex health disorders that are driven by intersecting pathophysiology that are often trapped in vicious cycles of degeneration and cognitive decline. The usual diagnostic route of these dis...
The relationship between UGT1A1 gene & various diseases and prevention strategies [0.03%]
UGT1A1基因与各种疾病的关系及预防策略
Dan Liu,Qi Yu,Qing Ning et al.
Dan Liu et al.
UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and very low activity of UGT1A1 in the liver can be fatal or lead to lifel...
Extensive metabolism of flavonoids relevant to their potential efficacy on Alzheimer's disease [0.03%]
与黄酮类化合物潜在的阿尔茨海默病疗效相关的广泛代谢途径
Hongjun Xia
Hongjun Xia
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, the incidence of which is climbing with ever-growing aged population, but no cure is hitherto available. The epidemiological studies unveiled that chronic intake of flav...
Drug metabolic stability in early drug discovery to develop potential lead compounds [0.03%]
药物早期发现阶段的代谢稳定性在开发潜在候选药物中的作用
Siva Nageswara Rao Gajula,Nimisha Nadimpalli,Rajesh Sonti
Siva Nageswara Rao Gajula
Knowledge of the metabolic stability of a new drug substance eliminated by biotransformation is essential for envisaging the pharmacokinetic parameters required for deciding drug dosing and frequency. Strategies aimed at modifying lead comp...
Recent advances in drug transporter sciences: highlights from the year 2020 [0.03%]
2020年药物转运体研究进展亮点
Paresh P Chothe,Masanori Nakakariya,Charles J Rotter et al.
Paresh P Chothe et al.
Drug Metabolism Reviews has an impressive track record of providing scientific reviews in the area of xenobiotic biotransformation over 47 years. It has consistently proved to be resourceful to many scientists from pharmaceutical industry, ...
Aarzoo Thakur,Zhiyuan Tan,Tsubasa Kameyama et al.
Aarzoo Thakur et al.
A reliable, rapid, and effective bioanalytical method is essential for the determination of the pharmacokinetic, pharmacodynamic, and toxicokinetic parameters that inform the safety and efficacy profile of investigational drugs. The overall...
Rachel H Wilson,Christopher A Bradfield
Rachel H Wilson
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has been a molecule of interest for many years in the field of toxicolog...