Applicability of two automated disintegration apparatuses for rapidly disintegrating (mini)tablets [0.03%]
两种自动化崩解仪对快速崩解(微)片的适用性研究
Daniel Sieber,Alessia Lazzari,Julian Quodbach et al.
Daniel Sieber et al.
Objectives: Orally disintegrating (mini)tablets (OD(M)Ts) are of interest in the field of pharmaceutics. Their orodispersible character is defined by the disintegration time, which is measured with a basket apparatus acco...
Implantable and transdermal polymeric drug delivery technologies for the treatment of central nervous system disorders [0.03%]
用于中枢神经系统疾病治疗的植入式和透皮给药技术
Thiresen Govender,Yahya E Choonara,Pradeep Kumar et al.
Thiresen Govender et al.
The complexity of the brain and the membranous blood-brain barrier (BBB) has proved to be a significant limitation to the systemic delivery of pharmaceuticals to the brain rendering them sub-therapeutic and ineffective in the treatment of n...
Mei Lu,Haonan Xing,Tianzhi Yang et al.
Mei Lu et al.
This study aimed to enhance the dissolution of tadalafil, a poorly water-soluble drug by applying liquisolid technique. The effects of two critical formulation variables, namely drug concentration (17.5% and 35%, w/w) and excipients ratio (...
Magnetic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol micelles for docetaxel delivery in breast cancer: an in vitro study on two cell lines of breast cancer [0.03%]
磁性聚环氧己酸-caprolactam-聚乙烯乙二醇聚合物胶束作为乳腺癌体内载药的介导：一种体外实验研究在两种类型的乳腺癌细胞系上的应用
Jaleh Varshosaz,Abbas Jafarian Dehkordi,Sahar Setayesh
Jaleh Varshosaz
The aim of the present study was to load docetaxel (DCT) and Fe3O4 magnetic nanoparticles (MNPs) in polymeric micelles to concentrate them by an external magnetic field in target tissues. Oleic acid (OA) coated MNPs were prepared by hydroth...
Formulation and characterization of Turkish oregano microcapsules prepared by spray-drying technology [0.03%]
采用喷雾干燥技术制备和表征土耳其迷迭香微胶囊
Juste Baranauskaite,Liudas Ivanauskas,Ruta Masteikova et al.
Juste Baranauskaite et al.
The aim of this study was optimization of spray-drying process conditions for microencapsulation of Turkish oregano extract. Different concentrations of maltodextrin and gum arabic as encapsulating agents (wall material) as well as influenc...
Lack of a synergistic effect of arginine-glutamic acid on the physical stability of spray-dried bovine serum albumin [0.03%]
精氨酸-谷氨酸对喷雾干燥牛血清白蛋白物理稳定性协同作用的缺失
Mouhamad Reslan,Yusuf K Demir,Bernhardt L Trout et al.
Mouhamad Reslan et al.
Improving the physical stability of spray-dried proteins is essential for enabling pulmonary delivery of biotherapeutics as a noninvasive alternative to injections. Recently, a novel combination of two amino acids - l-arginine (l-Arg) and l...
Evaluation of γ-cyclodextrin effect on permeation of lipophilic drugs: application of cellophane/fused octanol membrane [0.03%]
γ-环糊精对亲脂性药物透皮渗透影响的评价：再生纤维素膜/融合油膜的应用
Chutimon Muankaew,Phatsawee Jansook,Thorsteinn Loftsson
Chutimon Muankaew
According to the Biopharmaceutics Classification System, oral bioavailability of drugs is determined by their aqueous solubility and the ability of the dissolved drug molecules to permeate lipophilic biological membranes. Similarly topical ...
Formulation design of oral pediatric Acetazolamide suspension: dose uniformity and physico-chemical stability study [0.03%]
乙酰唑胺口服混悬液的处方设计：剂量均匀度及理化稳定性的研究
Ana Santoveña,Javier Suárez-González,Cristina Martín-Rodríguez et al.
Ana Santoveña et al.
Context: The formulation of an active pharmaceutical ingredient (API) as oral solution or suspension in pediatrics is a habitual practice, due to the non-existence of many commercialized medicines in pediatric doses. It i...
Paclitaxel-loaded polymeric depots as injectable drug delivery system for cancer chemotherapy of hepatocellular carcinoma [0.03%]
载有紫杉醇的聚合物储库作为肝细胞癌化疗的注射给药系统
Norased Nasongkla,Pinunta Nittayacharn,Apichada Rotjanasitthikit et al.
Norased Nasongkla et al.
In this work, paclitaxel-encapsulated polymeric depots were prepared and characterized as drug delivery system for cancer chemotherapy against hepatocellular carcinoma. Effects of different parameters, including drug-loading content, polyme...
Characterization of ibuprofen microparticle and improvement of the dissolution [0.03%]
布洛芬微粒的性质及改善其溶解度的研究
Fuzheng Ren,Jianping Su,Hui Xiong et al.
Fuzheng Ren et al.
The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The mi...