Design and in vitro characterization of ivermectin nanocrystals liquid formulation based on a top-down approach [0.03%]
基于上至下方法的伊维菌素纳米晶体液体制备及体外研究
Walter Javier Starkloff,Verónica Bucalá,Santiago Daniel Palma et al.
Walter Javier Starkloff et al.
The aim of this study was to develop ivermectin (IVM) nanosuspensions (NSs) to improve the dissolution rate of this poorly water-soluble drug. Different NSs combining different stabilizers, i.e. poloxamer 188 (P188), polysorbate 80 (T80), p...
An integrated, quality by design (QbD) approach for design, development and optimization of orally disintegrating tablet formulation of carbamazepine [0.03%]
卡马西平口崩片的集成质量设计(QbD)方法学研究、开发及优化
Saurabh M Mishra,Bhagwan D Rohera
Saurabh M Mishra
The objective of the present study was to design and develop a formulation for orally disintegrating tablets (ODTs) of carbamazepine using quality by design principles. The target product profile (TPP) and quality target product profile (QT...
Determination of process variables affecting drug particle attrition withinmulti-component blends during powder feed transmission [0.03%]
粉末给料输送过程中多组分混合体系中活性物质粒子磨损影响因素的研究
John F Gamble,Andrew B Dennis,Paul Hutchins et al.
John F Gamble et al.
The aim of this study was to determine the location of attrition of formulated API particles within a powder feed system using a Morphologi G3-ID system, an image analyzer with integrated Raman capability enabling classification of particle...
Application of EPR spectroscopy to examine free radicals evolution during storage of the thermally sterilized Ungentum ophthalmicum [0.03%]
利用电子顺磁共振光谱法研究热压灭菌眼用软膏剂储存过程中自由基的演化行为
Paweł Ramos,Barbara Pilawa
Paweł Ramos
Free radicals formed during thermal sterilization of the Ungentum ophthalmicum were examined by an X-band EPR spectroscopy. The influence of storage time (15 min; 1, 2 and 3 days after heating) on free radical properties and concentrations ...
Design and evaluation of mucoadhesive oral films containing sodium hyaluronate using multivariate data analysis [0.03%]
利用多元数据分析制备和评价含透明质酸钠的黏膜粘附型口腔膜剂
Veronika Walicová,Jan Gajdziok,Sylvie Pavloková et al.
Veronika Walicová et al.
Context: Mucoadhesive oral films, with their prolonged residence time at the site of application, offer a promising approach for protection of the oral lesion surface. The addition of sodium hyaluronate of different molec...
Errors in reporting on dissolution research: methodological and statistical implications [0.03%]
关于溶解度研究报道的错误：方法学和统计学含义
Magdalena Jasińska-Stroschein,Urszula Kurczewska,Daria Orszulak-Michalak
Magdalena Jasińska-Stroschein
Objective: In vitro dissolution testing provides useful information at clinical and preclinical stages of the drug development process. Methods: ...
Enhancement of the aqueous solubility and permeability of a poorly water soluble drug ritonavir via lyophilized milk-based solid dispersions [0.03%]
利用冻干牛奶基固态分散体系改善不良水溶性药物利托那韦的溶解度和渗透性
Pradip W Dhore,Vivek S Dave,Suprit D Saoji et al.
Pradip W Dhore et al.
In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was developed with the goal of improving its aqueous solubility. The SD was prepared by lyophilization, and characterized for its physicochemical and fu...
The application of crystallization in the presence of additives to enable drug-in-capsule technology [0.03%]
添加剂存在下的结晶技术在药物胶囊中的应用研究
Yildiz Yilmaz,Faraj Atassi,Manuel Sanchez-Felix
Yildiz Yilmaz
Crystallization in the presence of additives such as surfactants, polymers or impurities has been widely investigated in the pharmaceutical and chemical industries in order to change the crystal habit or to obtain a more desirable polymorph...
Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration [0.03%]
口服给药后16-脱氢孕烯醇龙胆亭丙基-β-环糊精包合物的药代动力学研究
Yangyang Sun,Lili Jia,Hui Zhou et al.
Yangyang Sun et al.
16-Dehydropregnenolone (16-DHP) is an active compound with an unsatisfied in vivo behavior and poor water-solubility, which limits its clinical application. To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodex...
Monocyclic monoterpenes as penetration enhancers of ligustrazine hydrochloride for dermal delivery [0.03%]
单环单萜类化合物作为氯化丁公藤素经皮给药的透皮吸收促进剂
Jiaoying Wang,Cuilan Dong,Zijing Song et al.
Jiaoying Wang et al.
The purpose of this study was to explore the enhancing effects and the mechanism of monocyclic monoterpene penetration enhancers (menthol and menthone) on the transdermal absorption of ligustrazine hydrochloride (LH). Franz-type diffusion c...