Mucoadhesive niosomal in situ gel for ocular tissue targeting: in vitro and in vivo evaluation of lomefloxacin hydrochloride [0.03%]
用于眼部组织靶向的粘膜附着型非离子胶束囊泡原位凝胶：盐酸洛美沙星的体外及体内评价研究
Ahmed Abdelbary,Heba F Salem,Rasha A Khallaf et al.
Ahmed Abdelbary et al.
Eradication of ophthalmic infections depends on increasing transcorneal permeation and localizing antibiotics at ocular surface. This study aimed at formulating lomefloxacin HCl (LF) in the form of niosomes and evaluating the in vivo perfor...
Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system [0.03%]
壳聚糖/卵磷脂载胰岛素脂质体纳米囊泡口服递送系统
Mayyas Al-Remawi,Amani Elsayed,Ibrahim Maghrabi et al.
Mayyas Al-Remawi et al.
In the present work, insulin-chitosan polyelectrolyte complexes associated to lecithin liposomes were investigated as a new carrier for oral delivery of insulin. The preparation was characterized in terms of particle size, zeta potential an...
A review of semi-synthetic biopolymer complexes: modified polysaccharide nano-carriers for enhancement of oral drug bioavailability [0.03%]
半合成生物聚合物复合物综述：修饰多糖纳米载体改善口服药物的生物利用度
Mduduzi N Sithole,Yahya E Choonara,Lisa C du Toit et al.
Mduduzi N Sithole et al.
Semi-synthetic biopolymer complexes (SSBCs) have potential as nano-carriers for oral drug delivery due to their exceptional properties obtained by merging the properties of synthetic (e.g. good thermal and mechanical properties) with natura...
Development of metoprolol tartrate-loaded sustained-release pellets: effect of talc on the mechanism of drug release [0.03%]
酒石酸美托洛尔缓释微丸的制备及其滑石粉对药物释放机制的影响研究
Yuli Wang,Meiyan Yang,Ruifang Shen et al.
Yuli Wang et al.
Talc is one of the most commonly used antiadherents in the coating film. However, the mechanism of influence of talc on drug release has yet to be fully understood. In this study, metoprolol tartrate (MT)-loaded Eudragit NE 30 D-coated sust...
Multiple response optimization of processing and formulation parameters of Eudragit RL/RS-based matrix tablets for sustained delivery of diclofenac [0.03%]
基于EudragitRL/RS的矩阵片制备和处方参数的多响应优化以实现双氯芬酸的缓释给药
Ehab M Elzayat,Ali A Abdel-Rahman,Sayed M Ahmed et al.
Ehab M Elzayat et al.
Context: Multiple response optimization is an efficient technique to develop sustained release formulation while decreasing the number of experiments based on trial and error approach. ...
Interaction between the photosensitizer lumichrome and human serum albumin: effect of excipients [0.03%]
光敏剂Lumichrome与人血清白蛋白之间的相互作用：辅料的影响
Victoria J Valerón Bergh,Hanne Hjorth Tønnesen
Victoria J Valerón Bergh
Lumichrome (Lc) is a photodegradation product of riboflavin that can be used as a photosensitizer (PS) in antibacterial photodynamic therapy (aPDT). The binding of Lc with plasma proteins such as human serum albumin (HSA) could affect its e...
A mixed solvent system for preparation of spherically agglomerated crystals of ascorbic acid [0.03%]
一种制备抗坏血酸球形颗粒晶体的混合溶剂体系
Fuzheng Ren,Yaru Zhou,Yan Liu et al.
Fuzheng Ren et al.
The objective of this research was to develop a novel solvent system to prepare spherically agglomerated crystals (SAC) of ascorbic acid with improved flowability for direct compression. A spherical agglomeration method was developed by sel...
Evaluation of the effect of some additives on the efficiency of binder liquid in wet agglomeration of crystals [0.03%]
一些添加剂对湿式造粒中粘结剂液效率影响的评价研究论文
Maryam Maghsoodi,Hassan Nabizadeh,Ali Nokhodchi
Maryam Maghsoodi
Objective: Wet agglomeration is a process wherein dispersed particles are held together in an aggregated form by the presence of a small quantity of solvent which acts as binder liquid. In this work, the efficiency of bin...
Sara Al-Marabeh,Enam Khalil,Mohammad Khanfar et al.
Sara Al-Marabeh et al.
Azelaic acid is a dicarboxylic acid compound used in treatment of acne vulgaris. However, high concentration (ca 20%) is needed to guarantee the drug availability in the skin. The latter increases the incidence of side effects such as local...
Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films [0.03%]
概述关键质量属性(CQA)作为开发可分散薄膜的指导方针
Ana Filipa Borges,Cláudia Silva,Jorge F J Coelho et al.
Ana Filipa Borges et al.
Context: Orodispersible films have gained increasing relevance as a novel dosage form. Associated to their particular processing and multicomponent composition, there are a vast number of reasons to establish helpful deve...