Comparative study on the in vitro performance of blister molded and conventional lornoxicam immediate release liquitablets: accelerated stability study and anti-inflammatory and ulcerogenic effects [0.03%]
布氏压制和常规压片洛索洛芬钠口崩片的体外性能比较研究：加速稳定性试验及抗炎、溃疡作用
Doaa Ahmed El-Setouhy,Alaa Abdel-Rahman Gamiel,Alia Abd El-Latif Badawi et al.
Doaa Ahmed El-Setouhy et al.
Context: Lornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID). It shows limited solubility in the gastric pH, delayed bioavailability and pharmacodynamic effects with aggravated gastric side effects (due to...
Synthesis of surface-modified TREN-cored PAMAM dendrimers and their effects on the solubility of sulfamethoxazole (SMZ) as an analog antibiotic drug [0.03%]
表面改性的TREN核PAMAM树状分子的合成及其对类抗生素药物磺胺甲恶唑（SMZ）溶解性的影响
Mustafa Ulvi Gürbüz,Ali Serol Ertürk,Metin Tülü
Mustafa Ulvi Gürbüz
Sulfamethoxazole (SMZ) is a sulfonamide and used widely in the treatment of bacteriostatic and urinary tract infections with trimethoprim as an antibiotic. The problem with SMZ is its poor water solubility, therefore, low bioavailability in...
In vitro aerodynamic characteristics of aerosol delivered from different inhalation methods in mechanical ventilation [0.03%]
机械通气不同吸入方法的气溶胶体外气动学特征研究
Muhammad H E ElHansy,Marina E Boules,Heba Farid et al.
Muhammad H E ElHansy et al.
Aerodynamic characteristics of aerosol delivery during invasive mechanical ventilation (IMV) are mostly determined by inserting cascade impactor in the circuit. Impactor might have some effect on airflow within IMV. Hence, the aim of the pr...
Influence of sonophoresis on transdermal drug delivery of hydrophilic compound-loaded lipid nanocarriers [0.03%]
声控透皮给药促进脂质纳米载药体系经皮传输效应增强作用研究
Worranan Rangsimawong,Praneet Opanasopit,Theerasak Rojanarata et al.
Worranan Rangsimawong et al.
The effect of sonophoresis on the transdermal drug delivery of sodium fluorescein (NaFI)-loaded lipid nanocarriers such as liposomes (LI), niosomes (NI) and solid lipid nanoparticles (SLN) was investigated by confocal laser scanning microsc...
Preparation and evaluation of novel hydrogel based on polysaccharide isolated from Bletilla striata [0.03%]
基于铁皮石斛多糖的新型水凝胶的制备及评价研究
Xiuming Cui,Xingying Zhang,Ye Yang et al.
Xiuming Cui et al.
Natural polysaccharides are highly valued and extensively applied in drug delivery system for their desirable physical properties and unique bioactivities. In this work, natural polysaccharides from Bletilla striata (BSP) were successfully ...
Sibel Ilbasmis-Tamer,Fatmanur Tugcu-Demiroz,Ismail Tuncer Degim
Sibel Ilbasmis-Tamer
In the present study, carbon nanotube (CNT) membranes were prepared to predict skin penetration properties of compounds. A series of penetration experiments using Franz diffusion cells were performed with 16 different membrane compositions ...
Development, optimization and in vitro evaluation of norcantharidin loadedself-nanoemulsifying drug delivery systems (NCTD-SNEDDS) [0.03%]
雷公藤内酯醇自纳米乳药物传递系统的开发、优化及体外评价
Liya Zeng,Yalin Zhang
Liya Zeng
This study focused on developing a self-nanoemulsifying drug delivery system (SNEDDS) containing bioactive surfactants under an efficient screening approach for overcoming problems associated with the delivery of norcantharidin (NCTD), a hi...
The effect of PAMAM dendrimer concentration, generation size and surface functional group on the aqueous solubility of candesartan cilexetil [0.03%]
聚胺胺(dendrimer)浓度、分子量和表面官能团对坎地沙坦西拉酯水溶性影响的研究
Ali Serol Ertürk,Mustafa Ulvi Gürbüz,Metin Tülü
Ali Serol Ertürk
This article investigates the aqueous solubility of the poorly soluble drug candesartan cilexetil (CC) in the presence of poly(amidoamine) (PAMAM) dendrimers. The effect of variables such as concentration, generation size (G2-G4), and surfa...
Experimental design-based optimization of lipid nanocarrier as delivery system against Mycobacterium species: in vitro and in vivo evaluation [0.03%]
基于实验设计的脂质纳米递送系统对抗分支杆菌的优化：体内外评价
Afzal Hussain,Sandeep Kumar Singh,Priya Ranjan Prasad Verma et al.
Afzal Hussain et al.
The study aimed to optimize self-nanoemulsifying drug delivery system using experimental design using excipients holding innate anti-mycobacterium activities followed with characterizations for responses such as optical clarity (Y1), zone o...
Optimization of thermoreversible poloxamer gel system using QbD principle [0.03%]
基于QbD原理的热可逆型泊洛沙姆凝胶体系优化
Eunmi Ban,Dong-Jin Jang,Su-Jin Kim et al.
Eunmi Ban et al.
The objective of this study was to optimize thermoreversible gel formulations with respect to their gelation temperature and solubilizing capacity, using quality by design (QbD) principles based on design of experiment (DoE). Independent va...