Development and optimization of transferrin-conjugated nanostructured lipid carriers for brain delivery of paclitaxel using Box-Behnken design [0.03%]
使用Box-Behnken设计开发和优化用于脑递送的转铁蛋白结合纳米结构脂质载体紫杉醇
Jaber Emami,Mahboubeh Rezazadeh,Hojjat Sadeghi et al.
Jaber Emami et al.
The treatment of brain cancer remains one of the most difficult challenges in oncology. The purpose of this study was to develop transferrin-conjugated nanostructured lipid carriers (Tf-NLCs) for brain delivery of paclitaxel (PTX). PTX-load...
Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin [0.03%]
壳聚糖包覆脂质体作为抗病毒药物Triazavirin新型载体系统的制备
Ksenia V Kozhikhova,Maria N Ivantsova,Maria I Tokareva et al.
Ksenia V Kozhikhova et al.
Novel method for the coating of positively charged liposomes with modified chitosan was elaborated. Liposomes were prepared by stepwise extrusion through inorganic membranes (Anotop) of 0.2 and 0.1 μm pore sizes. Chitosan derivatives were ...
Xylitol as a potential co-crystal co-former for enhancing dissolution rate of felodipine: preparation and evaluation of sublingual tablets [0.03%]
用于增强非洛地平溶解速率的共结晶助晶剂木糖醇：口含片的制备及评价
Mona F Arafa,Sanaa A El-Gizawy,Mohamed A Osman et al.
Mona F Arafa et al.
Dissolution enhancement is a promising strategy for improving drug bioavailability. Co-crystallization of drugs with inert material can help in this direction. The benefit will become even greater if the inert material can form co-crystal w...
PLGA nanoparticles for intravitreal peptide delivery: statistical optimization, characterization and toxicity evaluation [0.03%]
用于玻璃体内肽药物递送的PLGA纳米颗粒：统计优化、表征及毒性评价
Rohit Bisht,Ilva D Rupenthal
Rohit Bisht
Frequent intravitreal injections are currently used to overcome the ocular barriers and provide sufficient drug to the posterior eye segment. However, intravitreal injections have been associated with a number of complications and high trea...
Development of a novel physico-chemically and microbiologically stable oral solution of flecainide for pediatrics [0.03%]
一种新型的普鲁卡因胺口服液的开发用于儿科病人，具有理化和微生物学稳定性
Ana Santoveña,Irma Charola,Javier Suárez-González et al.
Ana Santoveña et al.
There is as yet no commercialized preparation for oral administration of flecainide acetate (FA) to children. In such cases, manipulation of commercial tablets is the usual practice in pharmacy services of hospitals and compounding pharmaci...
Preparation of enteric-coated microcapsules of astaxanthin oleoresin by complex coacervation [0.03%]
利用复凝聚法制备虾青素树脂的肠溶微胶囊
Rongli Li,Rencai Chen,Weiwei Liu et al.
Rongli Li et al.
Astaxanthin oleoresin (AO) has a number of beneficial physiological functions. However, its sensitivity to light, heat, oxygen and gastric fluids has limited its application. In this paper, we describe the preparation of AO enteric microcap...
Quality by design (QbD) approach for design and development of drug-device combination products: a case study on flunisolide nasal spray [0.03%]
以氟尼缩松鼻喷雾剂为例的药械组合产品设计与开发的质量源于设计理念研究
Swapnil Sharadkumar Chudiwal,Mohamed Hassan G Dehghan
Swapnil Sharadkumar Chudiwal
The objective of the present study was to design and develop drug-device combination product in particular flunisolide nasal spray (FNS) using quality by design (QbD) approach. Quality target product profile (QTPP) of FNS was defined and cr...
Jaya Malladi,Kurex Sidik,Sutan Wu et al.
Jaya Malladi et al.
Tablet hardness, a measure of the breaking force of a tablet, is based on numerous factors. These include the shape of the tablet and the mode of the application of force. For instance, when a pentagonal-shaped tablet was tested with a trad...
Ciprofloxacin-imprinted hydrogels for drug sustained release in aqueous media [0.03%]
用于水介质中载药控释的环丙沙星分子印迹水凝胶研究
Sajedeh Kioomars,Somayeh Heidari,Bizhan Malaekeh-Nikouei et al.
Sajedeh Kioomars et al.
In this study several ciprofloxacin (CFX) imprinted and non-imprinted hydrogels were prepared and evaluated as ocular drug delivery systems in aqueous media. 2-Hydroxyethyl methacrylate (HEMA) was used as a solvent and backbone monomer, eth...
Joël Schlatter,Elodie Bourguignon,Elyes Majoul et al.
Joël Schlatter et al.
Adapted forms for administration to infants are limited. The proposed study was performed to propose oral liquid formulations of idebenone in Ora-Plus and either Ora-Sweet or Ora-Sweet SF, Ora-Blend, Ora-Blend SF and Inorpha. Each formulati...