Preparation and in vitro evaluation of melatonin-loaded HA/PVA gel formulations [0.03%]
载有褪黑素的HA/PVA凝胶剂型的制备及体外评价
Sakine Tuncay Tanrıverdi,Catalina Natalia Cheaburu-Yilmaz,Sonia Carbone et al.
Sakine Tuncay Tanrıverdi et al.
Melatonin-loaded hyaluronic acid (HA) and poly(vinyl alcohol) (PVA) gels were prepared by using freeze-thaw technique and an emulsion method followed by freeze-thaw technique to produce a new synergistic system for topical application. Free...
The effect of deuterium oxide on the conformational stability and aggregation of bovine serum albumin [0.03%]
重水对牛血清白蛋白构象稳定性及聚集行为的影响
Mouhamad Reslan,Veysel Kayser
Mouhamad Reslan
Protein aggregation is a significant problem affecting the integrity of proteins, and is a major hindrance to the development of biopharmaceutical products. Deuterium oxide (D2O), widely used in protein characterization studies, has been sh...
Improvement of solubility, dissolution and stability profile of artemether solid dispersions and self emulsified solid dispersions by solvent evaporation method [0.03%]
一种改进的青蒿琥酯包合物溶解度、溶出度及稳定性的方法
Muhammad Tayyab Ansari,Muhammad Sohail Arshad,Altaf Hussain et al.
Muhammad Tayyab Ansari et al.
The purpose of this study was to investigate changes in the water solubility of artemether; a poorly soluble drug used for the treatment of malaria. Different solid dispersions (SDs) of artemether were prepared using artemether and polyethy...
Losartan loaded liposomes improve the antitumor efficacy of liposomal paclitaxel modified with pH sensitive peptides by inhibition of collagen in breast cancer [0.03%]
载有氯沙坦的脂质体通过抑制胶原来改善经pH敏感肽修饰的脂质体紫杉醇在乳腺癌中的抗肿瘤疗效
Tai Xia,Qin He,Kairong Shi et al.
Tai Xia et al.
The dense collagen network in tumors restricts the penetration of drugs into tumors. Free losartan could inhibit collagen, but it would cause hypotension at the dosage of 10 mg/kg/d. In this study, losartan was encapsulated in liposomes (LS...
Approaches to developing fast release pellets via wet extrusion-spheronization [0.03%]
基于湿法挤出- spheronization技术的速释型微丸制剂工艺研究进展及挑战
Yu Xia,Chun-Yang Shi,Jian-Guo Fang et al.
Yu Xia et al.
Microcrystalline cellulose (MCC) is widely regarded as the excellent choice to manufacture pellets via wet extrusion-spheronisation (ES) process due to its excellent water uptake capability, water holding capacity, desirable rheological pro...
Free radical formation in chloramphenicol heated at different temperatures and the best thermal sterilization conditions - application of EPR spectroscopy and UV spectrophotometry [0.03%]
不同温度下氯霉素加热反应中自由基的形成及其最佳热灭菌条件的研究-EPR与UV法联用研究
Paweł Ramos,Barbara Pilawa
Paweł Ramos
Free radicals in thermally treated chloramphenicol were examined by electron paramagnetic resonance (EPR) spectroscopy. The parameters and shape of EPR spectra were analysed and free radical concentrations were obtained in the tested drug s...
Preparation and characterization of bee venom-loaded PLGA particles for sustained release [0.03%]
长效释放蜂毒PLGA颗粒的制备和表征
Min-Ho Park,Hye-Suk Jun,Jong-Woon Jeon et al.
Min-Ho Park et al.
Bee venom-loaded poly(lactic-co-glycolic acid) (PLGA) particles were prepared by double emulsion-solvent evaporation, and characterized for a sustained-release system. Factors such as the type of organic solvent, the amount of bee venom and...
A study of critical functionality-related characteristics of HPMC for sustained-release tablets [0.03%]
羟丙甲纤维素关键性能指标的研究及其在缓释片中的应用
Darjan Košir,Tadej Ojsteršek,Saša Baumgartner et al.
Darjan Košir et al.
The drug release profile from hydrophilic matrix tablets can be crucially affected by the variability of physicochemical properties of the controlled release agent. This study investigates and seeks to understand the functionality-related c...
Enhancing tablet disintegration characteristics of a highly water-soluble high-drug-loading formulation by granulation process [0.03%]
通过制粒工艺增强高载药量的 Highly Water-Soluble 高溶解性药物 tablet 的崩解特性
Preetanshu Pandey,Christopher Levins,Steve Pafiakis et al.
Preetanshu Pandey et al.
The objective of this study was to improve the disintegration and dissolution characteristics of a highly water-soluble tablet matrix by altering the manufacturing process. A high disintegration time along with high dependence of the disint...
Nimra Iqbal,Carla Vitorino,Kevin M G Taylor
Nimra Iqbal
The development of a transdermal nanocarrier drug delivery system with potential for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, is described. Lipid nanocarriers (LN), encompassing various solid:liqui...