Revisiting the role of sucrose in PLGA-PEG nanocarrier for potential intranasal delivery [0.03%]
白蛋白纳米粒的体内行为及其影响因素综述
A Bonaccorso,T Musumeci,C Carbone et al.
A Bonaccorso et al.
The efficient design of nanocarriers is a major challenge and must be correlated with the route of administration. Intranasal route is studied for local, systemic or cerebral treatments. In order to develop nanocarriers with suitable proper...
Design of microemulsion system suitable for the oral delivery of poorly aqueous soluble beta-carotene [0.03%]
一种适合口服给药的低水溶性β-胡萝卜素微乳制剂的设计
Cheng Peng,Darren Svirskis,Sung Je Lee et al.
Cheng Peng et al.
Beta-carotene is a potent antioxidant for maintaining human health. However, its oral absorption is low due to poor aqueous solubility of less than 1 μg/ml. A microemulsion delivery system was designed to solubilize beta-carotene toward en...
A study of water uptake by selected superdisintegrants from the sub-molecular to the particulate level [0.03%]
从亚分子到颗粒尺度的几种超级崩解剂吸水性研究
P Barmpalexis,P Syllignaki,K Kachrimanis
P Barmpalexis
Water diffusion through the matrix of three superdisintegrants, namely sodium starch glycolate (SSG), croscarmellose sodium (cCMC-Na) and crospovidone (cPVP), was studied at the sub-molecular level using Attenuated Total Reflectance (ATR)-F...
Real-time imaging as an emerging process analytical technology tool for monitoring of fluid bed coating process [0.03%]
实时成像作为一种新兴的过程分析技术工具，用于监测流化床包衣过程
Venkata Ramana Naidu,Rucha S Deshpande,Moinuddin R Syed et al.
Venkata Ramana Naidu et al.
A direct imaging system (EyeconTM) was used as a Process Analytical Technology (PAT) tool to monitor fluid bed coating process. EyeconTM generated real-time onscreen images, particle size and shape information of two identically manufacture...
Construction and cellular uptake behavior of redox-sensitive docetaxel prodrug-loaded liposomes [0.03%]
一种还原敏感的多西他赛前药载脂质体的构建及细胞摄取行为研究
Guolian Ren,Mengjuan Jiang,Weiling Guo et al.
Guolian Ren et al.
A redox-responsive docetaxel (DTX) prodrug consisting of a disulfide linkage between DTX and vitamin E (DTX-SS-VE) was synthesized in our laboratory and was successfully formulated into liposomes. The aim of this study was to optimize the f...
The influence of thermal treatment and type of insoluble poly(meth)acrylates on dissolution behavior of very soluble drug from hypromellose matrix tablets evaluated by multivariate data analysis [0.03%]
基于多元数据分析的热处理及难溶型聚（甲）丙烯酸酯类型对羟丙基纤维素矩阵片中高水溶性药物释放行为的影响研究
Katerina Kubova,Daniel Peček,Kristýna Hasserová et al.
Katerina Kubova et al.
Hypromellose matrices exhibit extended burst effect immediately after contact with aqueous medium, especially when a water-soluble drug is incorporated. The objective of this study was to reduce burst effect and maintain complete dissolutio...
Solution stability of Captisol-stabilized melphalan (Evomela) versus Propylene glycol-based melphalan hydrochloride injection [0.03%]
Captisol稳定梅法仑(Evomela)与丙二醇基盐酸梅法仑注射液的溶液稳定性比较
Ramsharan Singh,Jin Chen,Teresa Miller et al.
Ramsharan Singh et al.
Purpose: The objective of this study was to compare the stability of recently approved Captisol-stabilized propylene glycol-free melphalan injection (Evomela™) against currently marketed propylene glycol-based melphalan ...
Agglomeration of celecoxib by quasi-emulsion solvent diffusion method without stabilizer: effect of good solvent [0.03%]
无稳定剂情况下使用类乳化溶剂扩散法制备塞来昔布聚集体：良好溶剂的影响
Maryam Maghsoodi,Ali Nokhodchi
Maryam Maghsoodi
Aim: The aim of the present research is to investigate the feasibility of agglomeration of crystals by the quasi-emulsion solvent diffusion method without using a stabilizer. ...