Self-assembled mumio-stabilized bioactive gel systems for topical therapeutics of rheumatoid arthritis: Structural, rheological, cytocompatibility, and antimicrobial properties [0.03%]
自组装的mumio稳定型生物活性凝胶类风湿关节炎外用治疗系统：结构、流变学、细胞相容性和抗菌特性
Oyunchimeg Zandraa,Fahanwi Asabuwa Ngwabebhoh,Smarak Bandyopadhyay et al.
Oyunchimeg Zandraa et al.
In this study, we explore the development and evaluation of salicylate polyacrylic copolymer-stabilized gel systems incorporating mumio particulates as the primary bioactive agent for the effective treatment of rheumatoid arthritis. An expe...
Design and development of leflunomide loaded topical microsponge gel: Insights from Ex vivo and In vivo inflammatory studies [0.03%]
来氟米特载药微海绵凝胶的设计与开发：来自体内和体外炎症研究的见解
Nirmal Shah,Priyank Patel,Dipti Gohil et al.
Nirmal Shah et al.
Leflunomide, a frequently used medicament, falls under the category of disease modifying anti-rheumatoid drugs. The tablets are the only product available in the market which may lead to liver toxicity upon long term use. Being a class II d...
Development of Fenofibrate Solid Dispersion via Hot Melt Extrusion and 3D Printing Technologies [0.03%]
通过熔融挤出和3D打印技术制备非诺贝特固体分散体的研究
Janhavi Deshmukh,Kavish Sanil,Achref Cherif et al.
Janhavi Deshmukh et al.
This study aimed to develop an amorphous solid dispersion (ASD) of fenofibrate using Hot Melt Extrusion (HME) and 3D printing to evaluate the impact of preparation methods on ASD properties. Fenofibrate (10% w/w) was processed with Soluplus...
Engineered gastroretentive amorphous ferulate matrix: A novel raft-forming paradigm for enhanced bioavailability [0.03%]
工程化的胃滞留阿魏酸无定形矩阵：一种新型药用载体体系用于提高生物利用度
Ruedeekorn Wiwattanapatapee,Nattawat Chavasiri,Kijja Laohawiriyakamon et al.
Ruedeekorn Wiwattanapatapee et al.
This study aimed to enhance the solubility of ferulic acid using solid dispersion techniques and develop chewable tablets that neutralize stomach acid, form a protective gel layer, prevent gastric fluid reflux, and ensure prolonged retentio...
Study on controlling 3D printed drug release rates based on model structural adjustment [0.03%]
基于模型结构调节的调控3D打印药物释放速率的研究
Ruyue Dong,Xiaolu Han,Zhiqiang Tang et al.
Ruyue Dong et al.
As an emerging technology, 3D printing facilitates the fabrication of complex preparations and enables controlled drug release. This study integrated semi-solid extrusion (SSE) and fused deposition modeling (FDM) to develop core-shell struc...
Development and optimization of cilostazol loaded transethosomal gel for improved performance [0.03%]
一种新型cilostazol载药转移脂质体凝胶的开发及优化得改良性能
Midhat Rehman,Saba Sohail,Zakir Ali et al.
Midhat Rehman et al.
Deep vein thrombosis (DVT) is the third major leading cause of mortality and morbidity after cardiovascular disease and stroke. Cilostazol (CLZ) being one of the antiplatelet agents is effectively used in DVT. However, its oral administrati...
Advancing darunavir delivery: nanoformulation strategies and innovations in HIV therapy [0.03%]
达芦那韦传递方式的进步：纳米输送策略及艾滋病治疗中的创新疗法
Shreyash R Patil,Anjana Adhyapak,Rahul Koli
Shreyash R Patil
Darunavir, a nonpeptidic protease inhibitor, remains a cornerstone of antiretroviral therapy due to its potent activity against wild-type human immunodeficiency virus (HIV). However, its poor aqueous solubility and limited oral bioavailabil...
Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance [0.03%]
交联聚维酮功能性特征对片剂崩解性能的影响研究
Firas El Saleh,Hendrik Huebscher,Sergei Trofimov et al.
Firas El Saleh et al.
Crospovidone, a widely used superdisintegrant, exists in two pharmacopeial grades - Type A (coarser particle size) and type B (finer particle size). The differences in particle size among different crospovidone grades lead to variations in ...
Investigating the In Vivo Distribution Characteristics of Gel-in-Water Nanogel Emulsions and Demonstrating Their Efficacy in Treating C26 Tumor-Bearing Mice [0.03%]
利用体内成像技术研究凝胶纳米乳的分布特性及其抗肿瘤效果
Yi Zhang,Jannatul Fardous,Ryota Doi et al.
Yi Zhang et al.
Nanotechnology has been advancing drug delivery systems (DDSs) for decades. Nanoparticle DDSs, in which nanometric carriers deliver drugs to the target site, are highly valued for cancer treatment. In this study, based on nanoemulsion techn...
HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: Development and anti-colitis evaluation [0.03%]
以汉黄芩素为模型药物的自微乳化给药系统研究及其抗结肠炎评价
Jie Wang,Xuemei Gu,Zhiyang Lv et al.
Jie Wang et al.
This study developed a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-functionalized supersaturated self-nanoemulsifying drug delivery system (HPMCAS-SNEDDS@BA) to address the poor solubility and bioavailability of baicalin (BA), ...