Carvedilol Microemulsion-Loaded Oleogel for Oral Delivery: Investigation of In Vitro Drug Release and Evaluation of Chemical and Physical Stability [0.03%]
口服给药的卡维地洛微乳载油凝胶的研究：体外药物释放及化学和物理稳定性评价
Ibtihal Abuhamdeh,Kamal Sweidan,Rania Hamed
Ibtihal Abuhamdeh
A semisolid oral formulation of carvedilol microemulsion-loaded oleogel (CARV-MEOG), filled in hard gelatin capsules, was developed and investigated for in vitro dissolution at different physiological pH levels. In vitro dissolution studies...
Polymeric nanogels loaded with Eugenia uniflora L. dry extract: the role of span® 80 in rheology, release, and skin permeation [0.03%]
含月桂叶提取物的聚合纳米凝胶：span® 80在流变学、释放及皮肤渗透中的作用
Leandro Leal Kloppel,Bruno Dos Santos Souza,Gabriella Alves et al.
Leandro Leal Kloppel et al.
Fungal skin infections remain a global health concern, and current topical treatments often present limitations in efficacy and skin permeation, highlighting the need for innovative actives and delivery systems. Eugenia uniflora L. (EU) has...
Seyed Mohammad Iman Moezzi,Sara Masoumi Shahrbabak,Sogand Amiri et al.
Seyed Mohammad Iman Moezzi et al.
The rapid growth in the number of patients with psychological disorders puts immense pressure on the economy, society, and healthcare systems. Various classes of drugs have been approved for different psychological disorders; however, a vas...
Preparation of rhein-loaded hyaluolimosomes as a topical nanocarrier for melanoma: Physicochemical characterization, ex-vivo permeation and human melanoma cell line studies, A375 [0.03%]
作为黑色素瘤局部给药的纳米载体的番红花醇锁释放透明质酸胶束的制备：物理化学特征，体外透皮和人类黑色素瘤细胞系A375研究
Mahmoud M A Ismail,Ossama Y Abdallah,Marwa M Essawy et al.
Mahmoud M A Ismail et al.
Rhein (RH) is a promising phytochemical with well-documented pharmacological effects in several types of cancer. However, its pharmacological activity in skin cancer has not been studied. Moreover, RH suffers numerous limitations that handi...
Niosomal versus cubosomal gels of cetirizine hydrochloride: Cost-effective permeation enhancement for potential transdermal application [0.03%]
富马酸酮替芬尼油体和立方凝胶的经皮渗透性能研究
Esraa M Elboushy,Azza A Hasan,Gehan F Balata et al.
Esraa M Elboushy et al.
Cetirizine hydrochloride, an antihistamine drug, demonstrated potential off-label use for management of androgenic alopecia (Aga). The aim of the current study was cost-effective preparation of niosomal and cubosomal gels containing Cetiriz...
Ivermectin-Based Therapeutics: Modern Dosage Forms and Drug Delivery Innovations [0.03%]
基于伊维菌素的治疗：现代剂型和药物递送创新
Meryem Kocas,Tansel Comoglu
Meryem Kocas
Ivermectin (IVM), a broad-spectrum antiparasitic agent that has been extensively used in both human and veterinary medicine for decades. Conventional formulations of IVM are challenged by poor aqueous solubility, low bioavailability, and li...
Smart Microneedle Platforms for Skin Cancer Therapy: A Review of Stimuli-Responsive and Targeted Drug Delivery Systems [0.03%]
用于皮肤癌治疗的智能微针平台：刺激响应及靶向药物输送系统综述
Nisha Bharti,Viresh Kumar,Subhrojyoti Mukherjee et al.
Nisha Bharti et al.
Skin cancer's rising global incidence and the significant limitations of conventional therapies, such as systemic toxicity and drug resistance, necessitate the development of more effective and personalized treatment strategies. The emergen...
Preliminary Assessment of Repurposed Mebendazole Nano-Systems for Passive Targeting and Potential Treatment of Bone Metastasis [0.03%]
甲苯达唑纳米系统被动靶向和潜在治疗骨转移的初步评估研究
Nouran M Atia,Ossama Y Abdallah,Heba A Hazzah et al.
Nouran M Atia et al.
Bone metastasis is commonly observed in cancer patients, necessitating high-dose chemotherapy for effective treatment. Despite its challenging physicochemical properties, repurposing mebendazole (Meb) has shown promise in inhibiting cancer ...
Fabrication and Characterization of Coenzyme Q10-Loaded Nanofibers for Potential Biomedical Applications [0.03%]
用于生物医学应用的辅酶Q10载药纳米纤维的制备与表征
Esra Oğuz,Tuğçe Tayyar,Aysun Özdemir et al.
Esra Oğuz et al.
Coenzyme Q10 (CoQ10) is an essential molecule that plays a role in mitochondrial oxidative phosphorylation and acts as a powerful antioxidant. In this study, CoQ10-loaded nanofibers were developed and characterized via electrospinning metho...