Clobetasol Propionate Loaded Nanostructured Lipid Carrier Gel: Formulation Strategy and In Vitro Performance Evaluation [0.03%]
丙酸氯倍他索载纳米结构脂质载体凝胶的制备策略及体外性能评价
Mine Diril,Esra Karataş,H Yeşim Karasulu
Mine Diril
Clobetasol propionate (CP) is a potent Class I corticosteroid widely used to treat dermatological conditions; however, its poor aqueous solubility limits bioavailability. In this study, a nanostructured lipid carrier (NLC)-based gel was dev...
Comparative in vivo assessment of hair-growth efficacy using nanostructured lipid carriers individually loaded with lavender oil or tea seed oil [0.03%]
载有薰衣草油或茶树籽油的纳米结构脂质载体体外促进毛发生长效果比较研究
Omnia M Sarhan,Eman M El-Noby,Hasnaa A El-Shaat et al.
Omnia M Sarhan et al.
BackgroundThis study aimed to formulate nanostructured lipid carriers loaded with tea seed or lavender oil to enhance hair regrowth via improved follicular penetration, as an alternative to conventional alopecia therapies.MethodologyNLCs we...
Morin-loaded water-soluble nanomicelles as a novel anti-alcohol intoxication medication [0.03%]
水溶性纳米胶束载茅苍术素用于抗宿醉的新药开发研究
Chuanxu Luo,Linlin Zhao,Yu Chen et al.
Chuanxu Luo et al.
Acute alcohol intoxication (AAI) poses serious health risks. Currently, no approved therapy effectively treats both CNS depression and tissue damage in AAI. Standard care, including supportive measures and off-label naloxone, manages respir...
A critical comparative insight on nanocarrier-based intranasal delivery of statins for neuroprotective applications [0.03%]
纳米载体介导的他汀类鼻用药物递送系统在神经保护应用中的比较研究评论
Ravi Paruparla,Manisha Lalan,Pranav Shah et al.
Ravi Paruparla et al.
Background: The incidence of central nervous system (CNS) disorders is rising globally, particularly as the prevalence of neurodegenerative diseases increases. The primary challenge in such cases is limited transport of t...
Hydrogel nanoparticles of retinol acetate via modified rapid expansion of supercritical solution: design, optimization, and anticancer evaluation [0.03%]
通过改进的超临界溶液快速膨胀法构建视黄醇醋酸酯水凝胶纳米粒：设计、优化及抗肿瘤评价研究
Milind Velhal,Jyotiram Sawale
Milind Velhal
Polymeric nanoparticles are promising drug carriers due to their biocompatibility, sustained release, and improved therapeutic efficacy; however, conventional fabrication methods often suffer from broad size distribution, low encapsulation ...
In vitro antifungal and antibiofilm evaluation of reduction-responsive ketoconazole-loaded nanoparticles based on cystamine-modified poly (isobutene-alt-maleic anhydride) polymer [0.03%]
基于半胱胺修饰的异丁烯和马来酸酐交替共聚物载酮康唑还原响应型纳米粒的体外抗真菌和抗生物被膜评价
Fuyou Wang,Qingmin Liu,Wenhui Wu et al.
Fuyou Wang et al.
Purpose: In order to develop reduction-responsive nano-drug delivery system for encapsulating antifungal drugs. Methods: Herein, with p...
Galactosylated Bilosomes for Liver-Targeted Delivery of Ledipasvir: Optimization, Conjugate Synthesis, and Cellular Evaluation [0.03%]
用于肝靶向递送Ledipasvir的半乳糖化双层脂质体：优化、接合物合成和细胞评价
Zeinab Hassan Gaafar,Suzan Fangary,Ahned K B A W Farouk et al.
Zeinab Hassan Gaafar et al.
Ledipasvir is one of the direct-acting antiviral agents used for treating hepatitis C virus (HCV) infection. To achieve dose reduction and cost-effective therapy, this study aimed to enhance the interaction of ledipasvir with HCV-infected h...
Parabens potential as polymer additives in supersaturable formulations [0.03%]
对羟基苯甲酸酯作为超饱和制剂中聚合物添加剂的潜力研究
Maryam Maghsoodi,Mehdi Ezzati Nahand,Ali Nokhodchi
Maryam Maghsoodi
This study aimed to assess two parabens, methylparaben and propylparaben, as additives to study their effects on the ability of the eudragit S100 (EU) in stabilizing the supersaturation of dipyridamole (DP). Capability of EU/parabens binary...
Deep Eutectic Solvents as Emerging Carriers for Antihyperlipidemic Drugs: Current Trends and Future Perspectives [0.03%]
深共晶溶剂作为抗高脂血症药物的新兴载体：当前趋势与未来展望
Sushant Gaikwad,Ambar Marne,Ashwini Gawade et al.
Sushant Gaikwad et al.
The therapeutic effectiveness of the most antihyperlipidemic drugs, particularly Biopharmaceutics Classification system Class II drugs like statins, is severely limited by their low aqueous solubility and resulting low and variable oral bio...
A comparative study of spray drying and jet milling in the preparation of nintedanib dry powder for inhalation [0.03%]
奈拉替尼干粉吸入剂的制备中喷雾干燥和气流磨粉法的比较研究
Jingyu Shi,Hao Miao,Changhui Li et al.
Jingyu Shi et al.
This study optimized nintedanib dry powder for inhalation (DPI) and compared it with organic solvent-based spray drying and jet milling. A solid dispersion of nintedanib, polyvinyl alcohol (PVA), and leucine was produced by spray drying fro...