Intensification of quercetin nanobubble formulation and performance by multi-factor optimization and interaction analysis [0.03%]
多因素优化及相互作用分析强化槲皮素纳米气泡制剂性能
Hema Kumar A V,Chamakuri Kantlam
Hema Kumar A V
The natural flavonoid Quercetin (QT) showed a potential for various health benefits, but its pharmaceutical applications are hindered by low solubility, permeability, and limited bioavailability. This research aimed to synthesize, develop a...
Pharmaceutical excipients in pediatric and geriatric drug formulations: safety, efficacy, and regulatory perspectives [0.03%]
儿科和老年用药配方中药用辅料的安全性、有效性和监管角度审视
Tansel Comoglu,Emine Dilek Ozyilmaz
Tansel Comoglu
Pharmaceutical excipients are indispensable components of drug formulations, playing critical roles in enhancing stability, improving bioavailability, and ensuring patient compliance. In pediatric and geriatric populations, the selection of...
Formulation and evaluation of ibrutinib-loaded glycyrrhizic acid conjugated ovalbumin nanoparticles and ibrutinib-glycyrrhizic acid complex for improved oral bioavailability [0.03%]
一种异环茋类化合物及其在制备抗肿瘤药物中的应用
Prateeksha Prakash Kamath,Pragathi Devanand Bangera,Divya Dhatri Kara et al.
Prateeksha Prakash Kamath et al.
The study aimed at enhancing the oral bioavailability of the BCS class 2 drug Ibrutinib (IBR), which exhibits low solubility (0.002 mg/mL) and high permeability (3.9% oral bioavailability). This was achieved through the formulation and eval...
Transforming canagliflozin solubility using lipidic carrier and its pharmacokinetic study [0.03%]
基于脂质载体改善坎格列净溶解度及其药动学研究
Rutuja Deshmukh,Subhash Deshmane,Atish Sawant et al.
Rutuja Deshmukh et al.
The European Medicine Agency has approved canagliflozin (CGF) drug to improve glycemic control in patients with type II diabetes. Our study aimed to enhance the solubility and pharmacokinetics of canagliflozin. Since crystalline canaglifloz...
Correction [0.03%]
更正通知书
Bioavailability enhancement of formononetin by incorporation of natural bioenhancer in phospholipid complex [0.03%]
黄酮类化合物葛根素磷脂复合物的制备及其体内吸收研究
Arun Agarwal,Shailesh Dadge,Richa Garg et al.
Arun Agarwal et al.
Formononetin (FNT) has limited application due to poor water solubility and substantial phase II metabolism. In the present study, we used phospholipid complex (PC) containing FNT and UDP-glucuronosyltransferase (UGT1A1) inhibitor piperine ...
Mechanistic characterization of fast dissolving PVP-I powder with multipolymer approaches and investigation on their molecular interaction [0.03%]
采用多重聚合物法表征快速溶解的PVP-I粉体并研究其分子间相互作用机制
Maytawee Wutthichokmongkhonkul,Rutthapol Sritharadol,Teerapol Srichana
Maytawee Wutthichokmongkhonkul
Povidone-iodine (PVP-I) is widely used as an antiseptic in medical applications. However, its effectiveness is limited by certain drawbacks, such as low solubility in water and high volatility. Therefore, a formulation of a stable solid PVP...
Spray dried polymyxin B liposome for inhalation against gram-negative bacteria [0.03%]
喷雾干燥多粘菌素B脂质体吸入剂对抗革兰氏阴性菌感染
Thaddeus Harrison Gugu,Emmanuel Maduabuchi Uronnachi,Ekawat Thawithong et al.
Thaddeus Harrison Gugu et al.
This study aimed to provide an alternative and effective delivery system to combat polymyxin B (PMB) toxicity and bacterial resistance through inhalation therapy. PMB was formulated as liposomal dry powder for inhalation using thin-film hyd...
Nanoformulated fenbendazole as an attractive approach for treating neurocysticercosis: in vitro and in vivo studies [0.03%]
纳米化分装芬苯达唑治疗神经囊虫病的体内外研究
Yngrid Batista da Silva,Giselle Bedogni,Guaraciara de Andrade Picanço et al.
Yngrid Batista da Silva et al.
Purpose: This work aimed to develop fenbendazole nanocrystals to evaluate their effects on the energetic metabolism of Taenia crassiceps cysticerci, following an intracranial inoculation in mice. ...
In vitro skin permeation of flavonoid esters enzymatically derived from natural oils: release mechanism from gel emulsion, stability, and dermatological compatibility [0.03%]
从天然油中酶法制备的黄酮醇酯体外透皮渗透性：凝胶乳膏中的释放机制，稳定性及皮肤相容性研究
Ana Milivojević,Marija Ćorović,Anja Petrov Ivanković et al.
Ana Milivojević et al.
Due to their broad spectrum of biological activities and attractive pharmacological properties, flavonoids are very promising molecules for application in skin care products. In this study, phloridzin and naringin medium- and long-chain fat...