'Applications of machine learning in liposomal formulation and development' [0.03%]
“机器学习在脂质体配方与开发中的应用”
Sina Matalqah,Zainab Lafi,Qasim Mhaidat et al.
Sina Matalqah et al.
Machine learning (ML) has emerged as a transformative tool in drug delivery, particularly in the design and optimization of liposomal formulations. This review focuses on the intersection of ML and liposomal technology, highlighting how adv...
Inhibition of growth and lung metastasis of breast cancer by pH-responsive methotrexate/curcumin-loaded chitosan-stabilized nanoemulsions [0.03%]
pH响应型载methotrexate/curcumin壳聚糖稳定纳米乳液对乳腺癌生长和肺转移的抑制作用研究
Mehrnoosh Nikpour,Zahra Karami,Samaneh Rafieenia et al.
Mehrnoosh Nikpour et al.
Chemotherapeutic agents are widely used to combat breast cancer. However, due to their non-selective biodistribution, their usage is associated with severe adverse effects on healthy tissues. In this study, a chitosan-stabilized nanoemulsio...
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer [0.03%]
NGR-聚(2-乙基-2-恶唑烷酮)-胆甾醇甲碳酸酯可增强芹菜素脂质体在三阴性乳腺癌中的抗肿瘤作用
Chengcheng Zhao,Jian Qin,Dingyu Zhang et al.
Chengcheng Zhao et al.
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirme...
Drug-Silica-Cellulose Ternary Matrix for the Oral Delivery of Cyclosporine A: In vitro and in vivo evaluation [0.03%]
用于环孢素A口服递送的药物-二氧化硅-纤维素三元基质：体外及体内评价
Chaudhari Pinal,Vivek M Ghate,Arun K Kodoth et al.
Chaudhari Pinal et al.
Purpose: Supersaturated formulations have been widely explored for improving the oral bioavailability of drugs by using mesoporous silica (MS) to generate supersaturation via molecular adsorption; however, this is followe...
Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells [0.03%]
布洛芬缓释制剂诱导牙周病相关细菌生物被膜的溶解和根面附着水平的改善：随机临床试验研究报告摘要
Ferhat Bostancı,Aslıhan Şengelen,Yunus Aksüt et al.
Ferhat Bostancı et al.
Glioblastoma, with a low survival rate, is an aggressive and difficult-to-treat lethal type of brain cancer. Indomethacin (IND), a non-steroidal anti-inflammatory drug, has antitumoral activity in many cancers, including gliomas. However, i...
Thymoquinone loaded lipid nanocapsule dispersion: two methods of preparation, characterization and in vitro evaluations for oral administration [0.03%]
胡莫茋载脂质纳米囊漂浮散体制备、表征及体外评价
Mouna Selmi,Amine Trabelsi,Nolwenn Lautram et al.
Mouna Selmi et al.
This work explores two methods to encapsulate Thymoquinone (TQ) into lipid nanocapsules (LNCs) for oral administration. TQ was added during the phase inversion temperature method (TQ-LNCs-1) or to unload LNCs dispersion (TQ-LNCs-2). LNCs we...
Targeted Delivery Strategy of Indocyanine Green-Mitoxantrone Loaded Liposomes Co-Modified with BTP-7 and BR2 For the Treatment of Glioma [0.03%]
用于胶质瘤治疗的BTP-7和BR2共修饰载吲哚菁绿-米托蒽醌脂质体的目标给药策略研究
Lin Jing,Jingguo Du,Yichao Dong et al.
Lin Jing et al.
Objective: This study aims to develop a dual-ligand-modified targeted drug delivery system by integrating photosensitizers and chemotherapeutic drugs to enhance anti-glioma effects. The system is designed to overcome the ...
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation [0.03%]
基于分子模拟的人参皂苷Rg_3包合物的形成及稳定机制研究
Shili Pan,Wei Shen,Xuehui Ding et al.
Shili Pan et al.
The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility of G-Rg3. Nevertheless, the molecular mechanisms underlying the interaction between G-Rg3 and cyclodext...
Enhancing the efficacy of zinc oxide nanoparticles by beta-carotene conjugation for improved anti-microbial and anti-tumor therapy for dental application [0.03%]
β-胡萝卜素佐剂锌氧化学治疗增强的抗菌及抗肿瘤疗法在牙科应用中的有效性研究
Mohammed Rafi Shaik,Siva Prasad Panda,Shaik Althaf Hussain et al.
Mohammed Rafi Shaik et al.
Zinc oxide NPs (ZnO NPs) are notable in nanomedicine for their exceptional physicochemical and biological properties. This study synthesizes and characterizes beta-carotene-coated ZnO NPs (BT-ZnO NPs) for potential anti-cancer and antimicro...
Thermoresponsive biomaterial system of irinotecan and curcumin for the treatment of colorectal cancer: in-vitro and in-vivo investigations [0.03%]
伊立替康和姜黄素热响应结直肠癌治疗材料系统的体内和体外研究
Aleena Maryiam,Sibgha Batool,Zakir Ali et al.
Aleena Maryiam et al.
This study aims to develop a thermoresponsive biomaterial system of irinotecan (IRT) and curcumin (CUR) nano-transferosomal gel (IRT-CUR-NTG) for targeting colorectal cancer (CRC). The IRT-CUR-NTs were statistically optimized and loaded int...