Black Seed Oil Boosts Antidiabetic Activity of Glibenclamide: Development of Solidified Self Nanoemulsifying Drug Delivery System and Evaluation in Streptozotocin-Induced Diabetic Rat Model [0.03%]
黑种子油增强格列本脲的抗糖尿病作用：开发固体自微乳化药物递送系统并评估其在链脲佐菌素诱导的糖尿病大鼠模型中的效果
Abdelrahman Y Sherif,Doaa Hasan Alshora,Ahlam Alhusaini et al.
Abdelrahman Y Sherif et al.
Self nano-emulsifying drug delivery system (SNEDDS) has been widely used to enhance dissolution and bioavailability of glibenclamide (GB). In addition, black seed oil, containing bioactive thymoquinone (TQ), showed promising antihyperglycem...
Enhanced Skin Penetration and Clinical Antifungal Activity of Eugenol Encapsulated in Aspasomes [0.03%]
肉桂醇封装在Aspasomes中增强的皮肤渗透和临床抗真菌活性
Muhammad Salah Eleleemy,Maha H Ragaie,Basma Hamdy Amin et al.
Muhammad Salah Eleleemy et al.
Fungal infections are among the common diseases affecting the skin, which necessitate either topical or systemic delivery of antifungal agents. Eugenol was reported to exhibit antifungal properties, but owing to its poor skin-penetration ab...
Chitosan Nanoparticle Encapsulation of Thymus Capitatus Essential Oil: In Vitro Release, Antioxidant, Antibacterial Activity and Cytotoxicity in MDA-MB-231 Cells [0.03%]
壳聚糖纳米粒对Thymus capitatus精油的包载：体外释放，抗氧化性，抑菌活性以及在MDA-MB-231细胞中的细胞毒性研究
Huseyin Beyaz,Doga Kavaz,Nahit Rizaner
Huseyin Beyaz
Thymus capitatus (Th. Ca) is known to treat mouth ulcers and respiratory infections in Cyprus. However, antioxidant, antibacterial and cytotoxic potential of Th. Ca. EO on MDA-MB-231 cells and its' encapsulation into nanoparticles has not b...
Preparation and characterization of Duloxetine-loaded nanofiber scaffold composed of polyvinyl alcohol and chitosan as wound healing agent, fabricated by electrospinning method [0.03%]
电纺制备聚乙烯醇和壳聚糖组成的度洛西汀负载型纳米纤维支架作为伤口愈合剂的制备及表征研究
Kimiya Pourdehghan,Faraz Najafi,Fatemeh Majdi et al.
Kimiya Pourdehghan et al.
Wound is a disruption in the epithelial integrity of the skin or mucosa, which is caused by internal or external pathological processes. In this study, a nanofiber as wound dressing loaded with Duloxetine was produced by electrospinning tec...
Exploring the Application of Single-step Drying in Lyophilization of High Protein Concentration Formulations [0.03%]
单步干燥在高蛋白浓度制剂冻干中应用的探索
Qi Zeng,Zhaowei Jin,Jeremy Guo
Qi Zeng
Single-step drying integrates sublimation and desorption process in one step. Here, single-step drying was proved to be applicable to formulations with or without viscosity reducers among high protein concentration lyophilization products (...
Assessment of therapeutic effectiveness of developed colchicine transnovasomes in treatment of Recurrent Aphthous Ulcer as monotherapy and combination therapy with platelet-rich plasma [0.03%]
开发的秋水仙碱跨新体作为单药治疗和富血小板血浆联合治疗复发性阿弗他溃疡的疗效评估
Soha M Kandil,Iman I Soliman,Marwa Hosni et al.
Soha M Kandil et al.
Transnovasomes is a new and exciting class of lipid-based nanovesicles. Colchicine (COL) is a hydrophilic natural alkaloid with anti-inflammatory and anti-mitotic features having oral administration and permeation defects. Recurrent Aphthou...
Insight into manufacturing of bespoke combination drug products containing carvedilol and simvastatin by fused deposition modelling [0.03%]
碳达洛尔和辛伐他汀的定制组合药物的熔融沉积成型制造洞察力
Lucas KorsgaardAndreasen,Emilie Victoria SlotAndreasen,Wuzhong He et al.
Lucas KorsgaardAndreasen et al.
The goal of this study was to explore the fabrication of a combination drug product containing two poorly soluble active pharmaceutical ingredients (APIs), carvedilol (CAR) and simvastatin (SIM), in therapeutically relevant doses (25 mg of ...
Preparation and characterization of immediate release 3D printed tablets using hot melt extruded amorphous cyclosporine A filament [0.03%]
使用热熔挤出的环孢素A无定形丝制作和检测即时释放3D打印药片
Jin-Hyuk Jeong,Chang-Soo Han,Ji-Hyun Kang et al.
Jin-Hyuk Jeong et al.
3D printing technology is gaining attention as a next-generation approach to drug formulation. Among 3D printing techniques, fused deposition modeling is cost-effective but depends heavily on suitable filaments. Hot melt extrusion enables f...
Preparation of diltiazem HCl modified release formulation using cation exchange resin as a single excipient [0.03%]
使用阴离子交换树脂作为辅料制备盐酸地尔硫卓缓释制剂研究
Khouloud A Alkhamis,Suhair S Al-Nimry
Khouloud A Alkhamis
Objective: Modified released formulations of diltiazem were previously prepared using cation exchange resins. However, multiple excipients were required to achieve the appropriate release rate. It was of interest to prepa...
Saccharomyces cerevisiae-derived Vesicles loaded with Dextromethorphan as a Candidate for the Management of Neuroinflammation related to Alzheimer's Disease [0.03%]
携有右美沙芬的萨尔莫氏酵母菌衍生囊泡可作为管理阿尔茨海默病相关的神经炎症的候选方法
Parastoo Valizadeh,Negin Mozafari,Hajar Ashrafi et al.
Parastoo Valizadeh et al.
Alzheimer's disease (AD) is a neurodegenerative disease that is associated with neuroinflammation. Dextromethorphan (DXM) exerts neuroprotective effects in many central nervous system injuries and neurodegenerative diseases. The cell wall o...