The effects of pH, temperature and protein concentration on the in vitro binding of flutamide to human serum albumin [0.03%]
pH、温度及蛋白浓度对氟他胺与人血清白蛋白体外结合的影响
Sara Esmaeilzadeh,Hadi Valizadeh,Parvin Zakeri-Milani
Sara Esmaeilzadeh
Human serum albumin (HSA) is the most abundant protein in plasma with a high ligand-binding capacity. This capacity impacts the pharmacokinetic properties of therapeutic drugs. In the present study, the binding properties of flutamide to HS...
MCC-mannitol mixtures after roll compaction/dry granulation: percolation thresholds for ribbon microhardness and granule size distribution [0.03%]
滚压/干法制粒后的MCC-甘露醇混合物：微硬度带和颗粒粒度分布的渗析阈值
Ana Pérez Gago,Peter Kleinebudde
Ana Pérez Gago
In roll compaction, the specific compaction force, the gap width and the roll speed are the most important settings as they have a high impact in the products obtained. However the mechanical properties of the mixture being compacted are al...
Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation [0.03%]
克霉唑阴道给药的粘附性在位凝胶剂型的设计、制备及体内外评价研究
Seda Rençber,Sinem Yaprak Karavana,Zeynep Ay Şenyiğit et al.
Seda Rençber et al.
The purpose of this study was to develop a suitable mucoadhesive in situ gel formulation of clotrimazole (CLO) for the treatment of vaginal candidiasis. For this aim, the mixture of poloxamer (PLX) 407 and 188 were used to prepare in situ g...
Development and evaluation of N-naphthyl-N,O-succinyl chitosan micelles containing clotrimazole for oral candidiasis treatment [0.03%]
用于治疗口腔念珠菌病的克霉唑包裹N-奈洛基-N，O-琥珀酰壳聚糖胶束的开发及评估研究
Prasopchai Tonglairoum,Thisirak Woraphatphadung,Tanasait Ngawhirunpat et al.
Prasopchai Tonglairoum et al.
Clotrimazole (CZ)-loaded N-naphthyl-N,O-succinyl chitosan (NSCS) micelles have been developed as an alternative for oral candidiasis treatment. NSCS was synthesized by reductive N-amination and N,O-succinylation. CZ was incorporated into th...
F Sakar,A Y Özer,S Erdogan et al.
F Sakar et al.
In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be ...
Influence of different surfactants on the physicochemical properties of elastic liposomes [0.03%]
不同表面活性剂对弹性脂质体理化性质的影响
R M Barbosa,P Severino,P S C Preté et al.
R M Barbosa et al.
Elastic liposomes are capable to improve drug transport through the skin by acting as penetration enhancers due to the high fluidity and elasticity of the liposome membranes. Therefore, elastic liposomes were prepared and characterized to f...
Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan [0.03%]
天冬氨酸作为辅无定形载体以改善缬沙坦的水溶性问题
Ying Huang,Qi Zhang,Jian-Rong Wang et al.
Ying Huang et al.
Co-amorphization has recently been shown to be a promising approach for stabilizing amorphous drugs and improving the dissolution rate of poorly water-soluble drugs. In this study, three basic amino acids were chosen as small molecular weig...
Progress in the use of microemulsions for transdermal and dermal drug delivery [0.03%]
微乳液在经皮和局部给药中的应用进展
Kevin Ita
Kevin Ita
Transdermal drug delivery continues to attract considerable interest in the scientific community. However, due to the hindrance provided by the stratum corneum, it is not possible to deliver most medications in therapeutically significant a...
Sulforaphane delivery using mPEG-PCL co-polymer nanoparticles to breast cancer cells [0.03%]
使用mPEG-PCL共聚物纳米颗粒向乳腺癌细胞递送硫代葡萄糖异氰酸酯
Hossein Danafar,Ali Sharafi,Hamidreza Kheiri Manjili et al.
Hossein Danafar et al.
Purpose: Among the potent anticancer agents, d,l-sulforaphane (SF) is very effective against many different types of cancer cells. Its clinical application is restricted because of its hydrophobicity, low gastrointestinal...
Mengqing Zhou,Ju Ao,Song Liu et al.
Mengqing Zhou et al.
Only one crystal form of metoprolol succinate (Form I) was reported during previous researches and production. In this study, a new polymorph of metoprolol succinate (here named as Form II) was discovered and investigated by X-ray diffracti...