The Evolving Landscape of JAK-STAT Inhibition in the Treatment of Immune Mediated Inflammatory Diseases [0.03%]
免疫介导性炎症疾病治疗中JAK-STAT抑制剂的开发进展及面临的挑战
Benjamin A Turturice,Dale Kobrin,Alexandra F Freeman et al.
Benjamin A Turturice et al.
Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs) function comprise a direct membrane-to-nucleus intracellular signaling pathway, facilitating rapid transcriptional changes in response to cytokines, growth ...
Ines Sturmlechner,Nathan K LeBrasseur,Cornelia M Weyand et al.
Ines Sturmlechner et al.
Inflammaging, the aberrant chronic inflammatory state at advanced age, is an immunological phenomenon associated with detrimental long-term health consequences, morbidity, and mortality. Although the precise etiology of inflammaging is elus...
Sofia Sirvent,Natalia Cuervo,Oscar Palomares
Sofia Sirvent
Seema Aceves,Mario C Manresa,Evan S Dellon et al.
Seema Aceves et al.
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by esophageal dysfunction and tissue eosinophilia that is often associated with food impaction and dysphagia. The disease is triggered by allergic hypersensitivi...
Corrigendum [0.03%]
勘误表
Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT+ ILC2 state linked to immune disease susceptibility [0.03%]
共同γ链细胞因子诱导出与免疫疾病易感性相关的表观遗传塑形的前体样KIT+ ILC2状态
Simone E M Olsthoorn,Anne Onrust-Van Schoonhoven,Marjolein J W de Bruijn et al.
Simone E M Olsthoorn et al.
Background: Group 2 innate lymphoid cells (ILC2s) are key effector cells of type-2 immunity. A subset of ILC2s, which expresses KIT (CD117), display increased phenotypic plasticity and were previously linked to severe ast...
Epigenetic gestational age acceleration in cord blood is associated with activated inflammatory gene pathways and childhood asthma [0.03%]
脐带血表观遗传学胎龄加速与激活的炎症基因通路及儿童哮喘有关
Adriana Y Prichina,Christine M Seroogy,Amy A Eapen et al.
Adriana Y Prichina et al.
Background: DNA methylation accurately predicts chronological age, including gestational age (GA). Previous studies have used CpGs on the EPIC or 450K arrays to generate epigenetic clocks for estimating GA. ...
Elisabetta Granato,Ida Cerqua,Fiorentina Roviezzo
Elisabetta Granato
Methodologic and analytic considerations regarding the estrogen-responsive ORMDL3-S1P axis in asthma [0.03%]
关于哮喘中雌激素反应性ORMDL3-S1P轴的方法学和分析考虑因素
Huan Xu,Tongdong Zeng,Gang Tian
Huan Xu