A Pragmatic Individually Randomized Trial to Evaluate Bivalent RSV Prefusion F Protein-based Vaccine Effectiveness for Preventing RSV Hospitalizations in Adults Aged 60 Years or Above (DAN-RSV): Rationale & Trial Design [0.03%]
老年人上呼吸道感染预防：伯克利收购2种RSV融合前F蛋白疫苗有效性的个体随机务实试验：研究背景与试验设计（DAN-RSV）
Mats C Højbjerg Lassen,Sine H Christensen,Niklas D Johansen et al.
Mats C Højbjerg Lassen et al.
Background: Respiratory syncytial virus (RSV) can cause serious illness in older adults and those with chronic conditions. While the bivalent RSVpreF vaccine has been shown to protect against RSV-related respiratory tract...
Pulsed Field Ablation-Related Hemoglobinuria and Acute Kidney Injury:Insights and Strategies for Effective Management [0.03%]
脉冲场消融相关的血红蛋白尿和急性肾损伤：有效管理的见解与策略
Kamala P Tamirisa,Javier E Sanchez,Vincenzo Mirco La Fazia et al.
Kamala P Tamirisa et al.
Pulsed field ablation has emerged as a novel technique for atrial fibrillation ablation, offering myocardial preferential ablation and safety advantages over traditional thermal energy methods. Complications such as hemolysis, hemoglobinuri...
Relationship Between Industry Payments to Physicians and Prescription Patterns for PCSK9is, ARNis and DOACs: A Report from the NCDR PINNACLE Registry [0.03%]
药企支付与PCSK9抑制剂、ARNI和DOAC的处方模式：来自NCDR PINNACLE注册中心的一项报告
Amarnath R Annapureddy,Karthik Murugiah,Luke Zheng et al.
Amarnath R Annapureddy et al.
Background: We examined the association of industry payments to physicians and prescriptions for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, angiotensin receptor-neprilysin inhibitor (ARNi), and dire...
Referral patterns and clinical outcomes in patients with severe aortic stenosis: A multicenter cohort study [0.03%]
重度主动脉瓣狭窄患者的转诊模式和临床结局：一项多中心队列研究
Azin Vakilpour,Michael G Levin,Emeka C Anyanwu et al.
Azin Vakilpour et al.
Background: Patients with severe aortic stenosis (AS) require timely follow-up by cardiac specialists and aortic valve replacement (AVR). This multi-center study evaluates how the specialty of the provider who ordered the...
Rationale and design of the REMBRANDT trial: A phase 3 study to evaluate the effect of obicetrapib/ezetimibe on coronary plaque characteristics [0.03%]
REMBRANDT研究的设计与立题依据：obicetrapib/依折麦布对冠状动脉斑块特征影响的III期临床试验
Cian P McCarthy,Christie M Ballantyne,Ron Blankstein et al.
Cian P McCarthy et al.
Introduction: Obicetrapib is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor that significantly lowers low-density lipoprotein cholesterol (LDL-C). Additive reductions in LDL-C occur when obicetrap...
Active Monitoring for AtriaL FIbrillation (AMALFI): rationale, protocol, and pilot for a pragmatic, randomized, controlled trial of remote screening for asymptomatic atrial fibrillation [0.03%]
主动监测房颤（AMALFI）：远距离筛查无症状性心房纤颤的实用、随机和控制试验的原因、协议及试点研究
Rohan Wijesurendra,Guilherme Pessoa-Amorim,Georgina Buck et al.
Rohan Wijesurendra et al.
Objectives: Screening for asymptomatic atrial fibrillation (AF) might reduce cardioembolic strokes and screening for asymptomatic AF is recommended by some international guidelines. However, any impact of AF screening on ...
Design and rationale of the HARTc 2.0 trial: a multicentre randomized controlled study on the impact of point-of-care hs-cTnI testing in prehospital ACS triage on diagnosis and cost-effectiveness [0.03%]
HARTc 2.0研究的设计与原理：急诊科hs-cTnI检测对急性冠脉综合征分诊、诊断及成本效益影响的多中心随机对照试验
Anne Catherine M H van der Lande,Nina M Diederiks,Enrico R de Koning et al.
Anne Catherine M H van der Lande et al.
Introduction: Chest pain accounts for ∼10% of emergency department visits, though most cases are not ACS, underscoring the need for effective prehospital triage. The HARTc 2.0 study evaluates the modified HEART score inc...
Efficacy and safety of low-dose rivaroxaban in elderly patients with atrial fibrillation for oral anticoagulation therapy: Rationale, design and study protocol for a multicenter randomized controlled trial (SAFE-AF) [0.03%]
利伐沙班低剂量在老年房颤患者口服用药疗效及安全性：多中心随机对照试验（SAFE-AF）的立题、设计和研究方案
Jiawei Han,Wenwei Qi,Shuo Yuan et al.
Jiawei Han et al.
Background: Non-vitamin K antagonist anticoagulant (NOAC) is considered the first-line treatment for atrial fibrillation (AF) patients to reduce the risk of stroke, especially in the elderly. However, robust clinical evid...
Incremental Cost of Complications after TAVR and SAVR in Contemporary Clinical Practice [0.03%]
经导管主动脉瓣植入术和外科主动脉瓣置换术后并发症的增量成本分析——基于当前临床实践的研究
James E Harvey rd,Michael Ryan,Candace Gunnarsson et al.
James E Harvey rd et al.
Introduction: Prior studies have demonstrated that peri-procedural complications are associated with increased healthcare costs after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TA...
The Effects of Low-Dose Colchicine on the Progression of Aortic Valve Stenosis: Rationale, Design, and Baseline Characteristics of the Colchicine and Inflammation in Aortic Stenosis (CHIANTI) trial [0.03%]
低剂量秋水仙碱对主动脉瓣狭窄进展影响的临床研究：CHIANTI试验的设计和基线特征分析
Niekbachsh Mohammadnia,Lucas T W Vestjens,Neil J Craig et al.
Niekbachsh Mohammadnia et al.
Background: Aortic valve stenosis (AS) is one of the most common valvular heart diseases worldwide. Its prevalence increases with age and is expected to rise further as the population ages. Untreated severe AS carries a t...