Distal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI (DR-STEMI): Rationale and Design of an International, Multicenter, Randomized Trial [0.03%]
STEMI患者冠状动脉造影中远端与传统桡动脉通路的对比研究（DR-STEMI）：国际多中心随机对照试验的方案和设计
Grigorios Tsigkas,Aikaterini Trigka-Vasilakopoulou,Anastasios Apostolos et al.
Grigorios Tsigkas et al.
Rationale: Transradial access (TRA) constitutes the cornerstone for cardiac catheterization and is recommended by the multiple recent guidelines, irrespective of clinical presentation. The existing literature has evaluate...
Effect of Cerebral Embolic Protection Device on New Cerebral Embolism During Transcatheter Aortic Valve Replacement: A Prospective Sentinel Registry [0.03%]
经导管主动脉瓣置换术中脑保护装置对新发脑栓塞的效应：前瞻性哨点登记研究
Han-Su Park,Chong Hyun Suh,Jung-Min Ahn et al.
Han-Su Park et al.
Background: Cerebral embolization is a common complication following transcatheter aortic valve replacement (TAVR). Cerebral embolic protection (CEP) devices have the potential to reduce embolic burden to the cerebral cir...
Beta-blocker side-effects in clinical practice: A nationwide approach [0.03%]
临床实践中心脏病患者β受体阻滞剂的不良反应：基于全国范围 registry 数据的分析
Peter Vibe Rasmussen,Jarl Emanuel Strange,Sebastian Kinnberg Nielsen et al.
Peter Vibe Rasmussen et al.
Background: Concerns regarding side-effects of beta-blockers (BBs) are frequent but data regarding the incidence of side-effects are conflicting and real-world data are sparse. Hence, we aimed to investigate the absolute ...
Understanding gaps in guideline-recommended adult congenital heart disease care: Data from 12 US health care centers [0.03%]
美国12家医疗中心儿童先天性心脏病指南执行情况的数据调查研究报告
Joseph Bayne,Rong Duan,Lindsey Rudov et al.
Joseph Bayne et al.
Background: Guidelines recommend lifelong care with adult congenital heart disease (ACHD) specialists for adults with congenital heart disease (CHD). However, such gaps in visits at specialized ACHD centers have not been ...
Medicare Coverage Gap Status, Adherence to Oral Anticoagulation, and Stroke Rates in Patients with Atrial Fibrillation [0.03%]
医疗保险缺口状态、口服抗凝药物依从性以及房颤患者的中风率
Josephine Harrington,Rohin K Reddy,Anthony Carnicelli et al.
Josephine Harrington et al.
Background: Prior to 2025, Medicare Part D included a coverage gap during which beneficiaries were responsible for substantially higher portions of medication costs. The impact of this on oral anticoagulant (OAC) prescrip...
PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator im-plantation: Design and Rationale of the PROFID EHRA randomised clinical trial [0.03%]
植入式心脏复律除颤器预防心梗后猝死的临床试验(PROFID)的设计与理论依据
Nikolaos Dagres,Chris P Gale,Ramesh Nadarajah et al.
Nikolaos Dagres et al.
Background: Randomised clinical trials from over 20 years ago demonstrated that an implantable cardioverter defibrillator (ICD) improved survival for patients with severely reduced left ventricular ejection fraction (LVEF...
Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening - The VICTORION-PLAQUE primary prevention trial [0.03%]
评估inclisiran在无既往心血管事件且筛选时未发现管腔狭窄病变患者中对动脉粥样硬化斑块影响的随机对照试验设计与合理性——VICTORION-PLAQUE一级预防研究
Pruthvi C Revaiah,Patrick W Serruys,Yoshinobu Onuma et al.
Pruthvi C Revaiah et al.
Background: The impact of low-density lipoprotein cholesterol (LDL-C) on atherosclerotic cardiovascular disease (ASCVD) risk is influenced by both the magnitude and duration of exposure. Patients with non-obstructive coro...
A Pragmatic Individually Randomized Trial to Evaluate the Effectiveness of High-Dose vs. Standard-Dose Influenza Vaccine in Older Adults: Rationale and Design of the DANFLU-2 Trial [0.03%]
丹麦DANFLU-2流感疫苗效力研究：高剂量与标准剂量随机对照试验的合理性及设计
Niklas Dyrby Johansen,Daniel Modin,Matthew M Loiacono et al.
Niklas Dyrby Johansen et al.
Background: The high-dose inactivated influenza vaccine (HD-IIV) has been shown to reduce the incidence of influenza infection compared with standard-dose inactivated influenza vaccine (SD-IIV); however, its effectiveness...
The Low-Risk TAVR Trials - A Critical Appraisal of the Current Landscape [0.03%]
低风险TAVR试验的批判性评估及当前研究格局分析
Troels Højsgaard Jørgensen,Hans Gustav Hørsted Thyregod,Stefan Blankenberg et al.
Troels Højsgaard Jørgensen et al.
The low-risk TAVR vs. SAVR RCTs - PARTNER-3, Evolut Low-Risk, DEDICATE, and NOTION-2 - demonstrate that TAVR is at least as effective as SAVR in terms of early mortality and disabling stroke, although outcomes varied across studies. The exc...
Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial [0.03%]
选择性C反应蛋白血浆吸附在ST段抬高型心肌梗死中的应用：CRP-STEMI随机对照试验的设计与立题依据
Sebastian J Reinstadler,Andreas Kronbichler,Martin Reindl et al.
Sebastian J Reinstadler et al.
Background: Despite the effectiveness of primary percutaneous coronary intervention (PCI) in treating ST-elevation myocardial infarction (STEMI), myocardial salvage is often incomplete, resulting in large infarct size and...