Neuronatin in Metabolic Regulation: Molecular Interplay in Obesity and Type 2 Diabetes Pathogenesis [0.03%]
神经因子在代谢调节中的作用：肥胖和2型糖尿病发病机制中的分子相互作用
Ting Zhang,Wantao Ju,Xinyu Han et al.
Ting Zhang et al.
Growing evidence has established the imprinted gene neuronatin (NNAT) as a key regulator in human metabolic disorders, particularly obesity and type 2 diabetes. Its expression is prominently detected in major neuroendocrine and metabolic ti...
Dan A Liebermann,Jonathan Soboloff
Dan A Liebermann
Lactobacillus acidophilus Ameliorates Inflammatory Bone Loss Under Postmenopausal Osteoporotic Conditions via Modulating the Gut-Resident RORγT- pTreg Cell Population [0.03%]
乳酸菌酸杆菌通过调节肠道常驻RORγT-pTreg细胞群来改善绝经后骨质疏松症条件下的炎性骨丢失作用
Asha Bhardwaj,Leena Sapra,Chaman Saini et al.
Asha Bhardwaj et al.
Research in the past decade has elucidated the explicit role of the immune system in the pathophysiology of osteoporosis. Recent studies have further unraveled the complex interactions between bone and immune cells and explored safe, effect...
A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP [0.03%]
neutrophil elastase在高糖、PMA及MDP诱导的podocytes功能障碍中的新角色
Tomasz Kulesza,Aleksandra Wróblewska,Justyna Sawicka et al.
Tomasz Kulesza et al.
Podocytes are not only the key regulators of glomerular filtration barrier dynamics but also exhibit immunological properties. They are capable of antigen presentation and possess a receptor system recognizing pathogen-associated molecular ...
Telomere Attrition-Induced Senescence in Human Pluripotent Stem Cell-Derived Astrocytes: Distinct Cellular and Functional Characteristics [0.03%]
人多能干细胞来源星形胶质细胞中端粒磨损诱导的衰老及其独特的细胞和功能特征
Dongyun Kim,Seo Hyun Yoo,Seung Soo Oh et al.
Dongyun Kim et al.
This study explored the role of telomere attrition in astrocytic senescence by pharmacologically inhibiting telomerase activity in human induced pluripotent stem cell-derived astrocytes. Treatment with the telomerase inhibitor BIBR1532 (BIB...
Parathyroid Hormone (1-34) Signaling for Bone Health in Breast Cancer Survivorship and Metastasis [0.03%]
乳腺癌幸存者和转移患者的骨健康：甲状旁腺激素（1-34）信号传导的作用
Shinyoung Oh,Ha Ram Oh,Chen Shen et al.
Shinyoung Oh et al.
Osteoporosis, fragility fractures, and pathologic fractures are increasingly recognized as long-term complications in cancer survivors. Women are more susceptible to bone loss than men, and breast cancer is the most common malignancy in wom...
Ruizhe He,Mengzhe Sun,Tiantian Liu et al.
Ruizhe He et al.
Skin aging is a complex biological process driven by the dynamic interplay of cellular senescence, molecular dysfunction, and microenvironmental remodeling. The aging microenvironment acts as both a consequence and a driver of skin aging, c...
From Single-Cell Atlas to Functional Validation: Critical Next Steps for Understanding Tip Cell-Mediated Communication in the Injured Spinal Cord [0.03%]
从单细胞图谱到功能验证：理解损伤脊髓中尖端细胞介导的通讯的关键下一步
DuJiang Yang,Jiexiang Yang,GuoYou Wang
DuJiang Yang
In their recent study, Zeng et al. (2025) employed single-cell RNA sequencing to delineate the landscape of spinal cord injury (SCI), highlighting a previously underappreciated communicative role for endothelial tip cells in engaging astroc...
ELF4/TRIB3/CDK6 Axis Promotes Cancer Stem Cell Activity in Endometrial Cancer [0.03%]
ELF4/TRIB3/CDK6轴促进子宫内膜癌干细胞活性
Chun-Yu Chen,Yueh-Chun Lee,Yu-Hao Huang et al.
Chun-Yu Chen et al.
Endometrial cancer (EC) is the most prevalent gynecological malignancy globally. Here, we explored the role of E74-like ETS transcription factor 4 (ELF4) in EC progression. Using the TISIDB web tool to analyze TCGA data, we found that eleva...
Mitochondrial and Glucose Metabolic Patterns in Pre-Granulosa Cells and Oocytes and Their Dysfunctions Induce Impaired Primordial Follicle Formation in Mice [0.03%]
小鼠卵泡形成障碍与卵母细胞和窦前颗粒细胞线粒体及糖代谢异常的关系研究
Yutong Yan,Wenhui Ma,Yanxue Li et al.
Yutong Yan et al.
In mammals, the establishment of primordial follicles (PFs) occurs in an orderly manner and is an energy-demanding process. However, the mechanisms underlying the supply and demand of energy metabolism during primordial follicle formation, ...