RING-Box E3 Ligase Target N-Terminal Lysine 55 to Regulate Turnover of Sp7 Protein [0.03%]
RING指环框E3泛素连接酶通过N端K55位点调控Sp7蛋白稳定性及其介导的成骨分化
Abeera Sikandar,Hani Ali,Anabia Javed et al.
Abeera Sikandar et al.
Specificity protein 7 (Sp7) is essential for osteoblast differentiation and bone formation. In humans, Sp7 gene mutations are associated with skeletal abnormalities, including osteogenesis imperfecta. Ubiquitylation regulates the cellular l...
Identification of New Potential Microtubule Stabilizers via Virtual Screen, Biological Evaluation, and Molecular Dynamics Simulation [0.03%]
基于虚拟筛选、生物评价和分子动力学模拟的微管稳定剂新骨架发现
Xiang-Long Chen,Xiu-Yun Shi,Li-Li An et al.
Xiang-Long Chen et al.
Microtubules have become an attractive target for human cancer treatment. Several microtubule stabilizers targeting for taxane site have been widely employed for various tumor treatments in clinic. In this study, to discover novel scaffolds...
Nicotinamide Promotes Apoptosis in Malignant Melanoma via PARP1 Inhibition and Mitochondrial Pathway Activation [0.03%]
烟酰胺通过PARP1抑制和激活线粒体途径促进恶性黑色素瘤细胞凋亡
Yao Yu,Zhizhan Ni,Bujun Ge et al.
Yao Yu et al.
Nicotinamide has been reported to promote apoptosis in malignant melanoma cells, however, its mechanism remains unclear. This study aims to predict and analyze the apoptotic targets of nicotinamide in malignant melanoma through network phar...
RETRACTION: Exosomes Derived From Adipose Tissue, Bone Marrow, and Umbilical Cord Blood for Cardioprotection After Myocardial Infarction [0.03%]
撤稿：心肌梗死后用于心脏保护的来自脂肪组织、骨髓和脐带血的外泌体
H. Xu, Z. Wang, L. Liu, B. Zhang, and B. Li, "Exosomes Derived From Adipose Tissue, Bone Marrow, and Umbilical Cord Blood for Cardioprotection After Myocardial Infarction," Journal of Cellular Biochemistry 121, no. 3 (2020): 2089-2102. http...
Differentiation of Human Umbilical Cord Mesenchymal Stem Cells Into Pre-Granulosa Cells and Further Maturation [0.03%]
人脐带间充质干细胞向原颗粒细胞分化及进一步成熟诱导
Cheng Zou,Zelan Yang,Yan Zou et al.
Cheng Zou et al.
Mesenchymal stem cells (MSCs) are adult stem cells with the capacity to differentiate into several cell types, including hepatocyte-like cells, neural-like cells, islet-like clusters and so on. However, the differentiation into ovarian-rela...
Current Advances in Anticancer Properties of Heptamethine Carbocyanine DZ-1 Conjugated to Artesunate: Generation of Reactive Oxygen Species [0.03%]
他七甲基碳花青DZ-1连接青蒿素抗肿瘤性能的最新研究进展：活性氧生成方面
Badrinath Narayanasamy,Sarah Helmueller,Yi Zhang et al.
Badrinath Narayanasamy et al.
Heptamethine cyanine dyes and anticancer agents based conjugates are being developed for enhanced targeting and killing of cancer cells. DZ-1 dye conjugated agents induced cytotoxicity and mechanism of action have been shown in previous stu...
Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches [0.03%]
利用药物再定位和虚拟筛选方法寻找治疗皮肤利什曼病的新精氨酸酶抑制剂
Eduarda Moreira Barreto,Gabriel Rodrigues Coutinho Pereira,Isadora de Salles Arêas et al.
Eduarda Moreira Barreto et al.
Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by...
RETRACTION: A Shared Comparison of Diabetes Mellitus and Neurodegenerative Disorders [0.03%]
撤稿：糖尿病和神经退行性疾病的共通之处比较研究
M. Morsi, A. Maher, O. Aboelmagd, D. Johar, and L. Bernstein, "A Shared Comparison of Diabetes Mellitus and Neurodegenerative Disorders," Journal of Cellular Biochemistry 119, no. 2 (2018): 1249-1256, https://doi.org/10.1002/jcb.26261. The ...
Preliminary Findings on Post-COVID Cardiovascular Risk: Transcriptional Regulation and Gene Expression Patterns [0.03%]
关于新冠疫情后心血管风险的初步发现：转录调控和基因表达模式
Vikash Sharma,Jitender Singh,Ashish Kumar et al.
Vikash Sharma et al.
Survivors of COVID-19 are facing a new vulnerability of encountering post-COVID complications, including cardiovascular diseases (CVDs). Despite the increasing prevalence of CVDs, post-COVID-induced cardiac abnormalities significantly escal...
Structure-Based Identification and Molecular Characterization of CID-2135609 as a Potent Small Molecule Modulator of HIV-1 Protease [0.03%]
基于结构的鉴定和分子特征分析一种有效的HIV-1蛋白酶小分子调节物CID-2135609
S Rehan Ahmad,Md Zeyaullah,Abdullah M AlShahrani et al.
S Rehan Ahmad et al.
HIV-1 protease is a key therapeutic target for antiretroviral drug development. In this study, a structure-based high-throughput virtual screening (HTVS) approach was employed to identify novel quinazoline-based inhibitors targeting the pro...