SPI1 Regulates Autophagy by Promoting ATG7 Transcription to Enhance Ferroptosis in Myocardial Ischemia/Reperfusion Injury [0.03%]
缺血再灌注损伤中SPI1通过促进ATG7转录调节自噬以增强铁死亡发生
Wu-Lin Li,Xiao Han,Wei-Long Pan et al.
Wu-Lin Li et al.
Myocardial ischemia/reperfusion injury (MIRI) commonly arises during medical procedures for coronary artery disease (CAD), a global health issue. Inhibiting autophagy-dependent ferroptosis has emerged as an effective strategy for MIRI treat...
Integrative Multi-Omics Analysis Unveils the Molecular Mechanisms by Which TP53 Mutation Influence Early Decitabine Resistance in Myelodysplastic Syndrome [0.03%]
整合多组学分析揭示TP53突变通过何种分子机制影响MDS早期地西他滨耐药性
Wei Chen,Xiaojing Ge,Hailing Xu et al.
Wei Chen et al.
The myelodysplastic syndrome (MDS) is group of clonal hematopoietic stem cell disorders typified by peripheral cytopenia, dysplastic hematopoietic progenitors, a hypercellular or hypocellular bone marrow, and a high risk of conversion to ac...
The Role of Hsp72 in Handing Misfolded Proteins Metabolism in Heat-Stressed Cells: Mechanisms and Hypotheses [0.03%]
热应激细胞中Hsp72蛋白在处理错误折叠蛋白质代谢中的作用：机制与假设
Yue Guo,Haotian Lan,Haoying Wang et al.
Yue Guo et al.
The accumulation of misfolded proteins within cells, often induced by stress, is a major contributor to cellular dysfunction. Heat shock proteins, which serve as critical chaperone molecules in response to stress-related damage, are essenti...
In Silico Study of Molecular Docking Between Lactoferrin and Autophagy-apoptosis Genes ATG3, ATG5, and ATG12 and In Vitro Study of Lactoferrin Effect on These Gene Expressions in Breast Cancer [0.03%]
乳铁蛋白与自噬-凋亡基因ATG3、ATG5和ATG12的分子对接模拟及对乳腺癌细胞中这些基因表达影响的体外研究
Seyedeh Fatemeh Noorani,Fatemeh Moradian,Havva Mehralitabar et al.
Seyedeh Fatemeh Noorani et al.
Cancer is a major global health problem. Considering the special role of lactoferrin (Lf) in inhibiting the growth of cancer cells, a new approach has emerged for cancer treatment. The present study aimed to investigate the effect of Lf on ...
Rescue of Aging-Dependent Reduction of Claudin-10b Expression by Glutamate in Mouse Intestinal MCE301 Cells [0.03%]
谷氨酸救援小鼠肠上皮细胞系MCE301中年龄相关性Claudin-10b表达降低的现象
Miki Tanabe,Shunsuke Matsuda,Yuta Yoshino et al.
Miki Tanabe et al.
Paracellular permeability of mineral ions and water in the intestines is restricted by claudins (CLDNs), which are key components of tight junctions (TJs). Glutamate (Glu) plays a role in regulating absorption mechanisms in the intestines, ...
Potential Mechanisms of Lipid-Soluble Vitamins Alleviate Brain Damage in Preterm Infants: Integration of Network Pharmacology and Molecular Docking [0.03%]
脂溶性维生素通过网络药理学和分子对接整合机制缓解早产儿脑损伤的潜在作用机制研究
Xiao Li,Li Liu
Xiao Li
Vitamin A, E, and other vitamins have been demonstrated to potentially be used in the treatment of brain injury in preterm infants; however, whether all types of vitamins can be utilized for this purpose remains unclear. In this study, we s...
Extracellular Ubiquitin Drives M2 Macrophage Polarization in Multiple Myeloma Through JAK1/STAT3-mediated Transcriptional Activation of CXCR4 [0.03%]
外源泛素通过JAK1/STAT3转录激活CXCR4驱动多发性骨髓瘤中M2型巨噬细胞极化
Xi Chen,Nan Hou,Tiancheng Luo et al.
Xi Chen et al.
Macrophage polarization engenders an immunosuppressive microenvironment, thereby facilitating the survival and epithelial-mesenchymal transition (EMT)-like changes of malignant plasma cells. Ubiquitin (Ub), a short polypeptide predominantly...
Bmpr2 Loss in the Vascular Endothelium Enhances Neoangiogenesis and Growth of Lung Metastatic Lesions in a Mouse Model of Breast Cancer [0.03%]
血管内皮细胞BMPR2缺失通过小鼠乳腺癌模型促进肺转移灶新生血管生成和生长
Jordan A Harry,Sofia I Skebo,Devon V Cole et al.
Jordan A Harry et al.
Bone morphogenetic protein-9 (BMP9) has been implicated as a regulator of metastasis and tumor angiogenesis, with contrasting studies demonstrating both pro- and antiangiogenic roles for BMP9 across different cancer cell lines and animal mo...
EXPRESSION OF CONCERN: Kaempferol Induces Apoptosis in Two Different Cell Lines via Akt Inactivation, Bax and SIRT3 Activation, and Mitochondrial Dysfunction† [0.03%]
表达关切：通过Akt失活、Bax和SIRT3激活以及线粒体功能障碍， kaempferol诱导两种不同细胞系凋亡
G. Marfe, M. Tafani, M. Indelicato, P. Sinibaldi-Salimei, V. Reali, B. Pucci, M. Fini and M. A. Russo "Kaempferol Induces Apoptosis in Two Different Cell Lines via Akt Inactivation, Bax and SIRT3 Activation, and Mitochondrial Dysfunction†,...