Tricarboxylic Acid (TCA) Cycle Enzyme Alpha-Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization [0.03%]
α-酮戊二酸脱氢酶(KGDH)为巨噬细胞极化调控的交汇点
Meijing Li,Ryan J Mailloux
Meijing Li
Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha-ketoglutarate (KG) d...
Bootsakorn Boonkaew,Wirawit Srivongtrakul,Chaiyaboot Ariyachet
Bootsakorn Boonkaew
Organ fibrosis represents a terminal pathological consequence of chronic tissue injury and contributes substantially to global morbidity and mortality, yet effective therapeutic options remain limited. Characterized by the persistent activa...
Intrinsic Disorder Status in Human Proteins Interacting With SARS-CoV-2 Proteins: Insights From Five Years of Translational Research [0.03%]
与SARS-CoV-2蛋白相互作用的人类蛋白质的内在无序状态：来自五年转化研究的见解
Muhamed Adilović,Betul Akcesme,Altijana Hromić-Jahjefendić et al.
Muhamed Adilović et al.
SARS-CoV-2 infection is driven by extensive interactions between viral proteins and host cellular factors, yet the structural properties of host proteins within these interaction networks remain incompletely understood. Intrinsically disord...
Harunobu Saito,Kenji Sugase
Harunobu Saito
Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self-assembly. This interference is particularly significant for intrinsically disordered proteins and low-compl...
TRIM32 Alleviates the Inflammation in Spinal Cord Injury Progression Through Inducing the Ubiquitination Degradation of TLR4 [0.03%]
TRIM32通过诱导TLR4泛素化降解缓解脊髓损伤炎症进展
Xiaolin Liu,Shoubo Chen,Jinnan Shi et al.
Xiaolin Liu et al.
Inflammatory response induced cell apoptosis plays a crucial role in the pathological process of secondary injury in spinal cord injury (SCI), and targeted reduction of secondary inflammatory response can effectively promote neuronal recove...
Bedaquiline Binding at the Leading Site of Mycobacterium tuberculosis ATP Synthase Induces Distinct Structural and Dynamic Changes [0.03%]
贝达奎林结合在结核分枝杆菌ATP合成酶主要部位引起独特的结构和动态变化
Pragya Anand,Yusuf Akhter
Pragya Anand
ATP synthase (ATPase) is a crucial molecular motor in Mycobacterium tuberculosis (Mtb), essential for energy production and oxygen-dependent pathogenesis. The enzyme consists of two distinct rotors: a membrane-embedded Fₒ unit and a cytoso...
Agrin Ablation in Osteoblasts Compromises Long Bone Structure and Osteoblastic Differentiation of Mesenchymal Stem Cells [0.03%]
基质细胞成骨分化及长骨结构形成需要成骨细胞中的agrin蛋白
Gabriela Camarneiro Siqueira,Maria Paula Oliveira Gomes,Letícia Faustino Adolpho et al.
Gabriela Camarneiro Siqueira et al.
Agrin is an important factor in maintaining skeletal architecture. However, the role of osteoblast-expressed agrin in bone tissue remains unexplored. Thus, we hypothesized that agrin-deficient osteoblasts negatively affect bone tissue homeo...
Muhammad Junaid,Hu Zeming,Yabin Zhu
Muhammad Junaid
Leptin, a hormone historically recognized for regulating appetite and energy homeostasis, is increasingly appreciated as a central mediator of immune function, metabolic integration, and tissue-specific signaling. Despite decades of researc...
Correction to "Resveratrol Pretreatment Enhanced Homing of SDF-1α-preconditioned Bone Marrow-Derived Mesenchymal Stem Cells in a Rat Model of Liver Cirrhosis" [0.03%]
白藜芦醇预处理增强SDF-1α预处理骨髓间充质干细胞向肝硬化大鼠模型归巢的矫正原文:Resveratrol Pretreatment Enhanced Homing of SDF-1α-preconditioned Bone Marrow-Derived Mesenchymal Stem Cells in a Rat Model of Liver Cirrhosis
Published Erratum
Journal of cellular biochemistry. 2026 May;127(5):e70092. DOI:10.1002/jcb.70092 2026
Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism [0.03%]
高血糖导致骨髓间充质干细胞成骨分化受损、成脂分化增加及代谢改变
Suzanna Shirazi,Ezaldeen Esawi,Zeyad D Nassar et al.
Suzanna Shirazi et al.
Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investig...