Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism [0.03%]
高血糖导致骨髓间充质干细胞成骨分化受损、成脂分化增加及代谢改变
Suzanna Shirazi,Ezaldeen Esawi,Zeyad D Nassar et al.
Suzanna Shirazi et al.
Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investig...
Orexin-A Inhibits Lipopolysaccharide-Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling [0.03%]
下丘脑催产素通过激活催产素受体抑制脂多糖诱导的小鼠原代星形胶质细胞迁移：涉及GABA信号通路
Hyunjin Shin,Sheu-Ran Choi,Dong-Wook Kang et al.
Hyunjin Shin et al.
It has been suggested that orexin-A (OXA) exerts neuroprotective and anti-inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed...
RETRACTION: Combined Supplementation of Vanadium and Fish Oil Suppresses Tumor Growth, Cell Proliferation, and Induces Apoptosis in DMBA-Induced Rat Mammary Carcinogenesis [0.03%]
撤回：钒和鱼油联合补充抑制肿瘤生长、细胞增殖并诱导DMBA诱导的大鼠乳腺癌变引起的凋亡
S. Manna, S. Das, M. Chatterjee, M. Janarthan, and M. Chatterjee, Journal of Cellular Biochemistry 112, no. 9 (2011): 2327-2339, https://doi.org/10.1002/jcb.23153. The above article, published online on 18 April 2011 in Wiley Online Library...
RETRACTION: Long Noncoding RNA lnc-ABCA12-3 Promotes Cell Migration, Invasion, and Proliferation by Regulating Fibronectin 1 in Esophageal Squamous Cell Carcinoma [0.03%]
撤稿：长链非编码RNA lnc-ABCA12-3通过调节食管鳞状细胞癌中的纤维连接蛋白1促进细胞迁移、侵袭和增殖
J. Ma, Y. Xiao, B. Tian, S. Chen, B. Zhang, J. Wu, Z. Wu, X. Li, J. Tang, D. Yang, Y. Zhou, H. Wang, M. Su, and W. Wang, "Long Noncoding RNA lnc-ABCA12-3 Promotes Cell Migration, Invasion, and Proliferation by Regulating Fibronectin 1 in Es...
New Insights Into the Role of Polo-Like Kinase 3 in Lung Tumorigenesis [0.03%]
polo样蛋白激酶3在肺肿瘤发生中的作用的新见解
Cen Li,Arko Samad,Casey Ostrowski et al.
Cen Li et al.
Polo-like kinase 3 (PLK3) plays major roles in cell cycle regulation, DNA repair, and cellular responses to hypoxia. Our prior studies demonstrated that PLK3 negatively regulates the hypoxic response by directly phosphorylating and destabil...
Structural and Functional Insights Into Lyn Kinase: From Immune Regulation to Therapeutic Targeting [0.03%]
Lyn激酶的结构和功能见解：从免疫调控到治疗靶向
Alisha Khan,Aaliya Taiyab,Gulam Mustafa Hasan et al.
Alisha Khan et al.
Lyn kinase, a member of the Src family of kinases, is a critical regulator of immune cell signaling, regulating key processes including activation, proliferation, survival, and apoptosis. Dysregulated Lyn kinase activity causes haematologic...
HEPES in Cell Culture Alters the Multi-Omics Profile Exhibited by Gaucher Disease Fibroblasts [0.03%]
HEPES影响Gaucher病成纤维细胞的多组学特征
Eleonore M Corazolla,Bauke V Schomakers,Maria M Trętowicz et al.
Eleonore M Corazolla et al.
Lysosomal function can be affected by components in cell culture. This in turn may influence cellular metabolism and, consequently, research and diagnostics outcomes. One such component is the commonly used pH buffer 4-(2-hydroxyethyl)-1-pi...
SPI1 Regulates Autophagy by Promoting ATG7 Transcription to Enhance Ferroptosis in Myocardial Ischemia/Reperfusion Injury [0.03%]
缺血再灌注损伤中SPI1通过促进ATG7转录调节自噬以增强铁死亡发生
Wu-Lin Li,Xiao Han,Wei-Long Pan et al.
Wu-Lin Li et al.
Myocardial ischemia/reperfusion injury (MIRI) commonly arises during medical procedures for coronary artery disease (CAD), a global health issue. Inhibiting autophagy-dependent ferroptosis has emerged as an effective strategy for MIRI treat...
Integrative Multi-Omics Analysis Unveils the Molecular Mechanisms by Which TP53 Mutation Influence Early Decitabine Resistance in Myelodysplastic Syndrome [0.03%]
整合多组学分析揭示TP53突变通过何种分子机制影响MDS早期地西他滨耐药性
Wei Chen,Xiaojing Ge,Hailing Xu et al.
Wei Chen et al.
The myelodysplastic syndrome (MDS) is group of clonal hematopoietic stem cell disorders typified by peripheral cytopenia, dysplastic hematopoietic progenitors, a hypercellular or hypocellular bone marrow, and a high risk of conversion to ac...