Elucidating the Antiglycation Potential of Plumbagin Against Methylglyoxal-Induced Glycation of Bovine Liver Catalase [0.03%]
普鲁士满抗甲基甘油糖基化损伤保护作用及机制研究
Faiza Iram,Ayesha Aiman,Deepanshi Vijh et al.
Faiza Iram et al.
Non-enzymatic glycosylation of proteins leads to the formation of advanced glycation end products (AGEs), implicated in oxidative stress and the progression of several chronic diseases. Among the reactive carbonyl compounds, methylglyoxal (...
Integrated Bioinformatic and Experimental Analysis Reveals the Molecular Mechanisms Underlying KDM1B/LSD2 Inhibition as a Therapeutic Strategy in Human Lung Adenocarcinoma [0.03%]
集成生物信息学和实验分析揭示KDM1B/LSD2抑制在人类肺腺癌治疗中的分子机制
Kayalvizhi Samuvel Muthiah,Sathan Raj Natarajan,Udesh Dhawan et al.
Kayalvizhi Samuvel Muthiah et al.
Lung cancer remains a major global health challenge, and the oncogenic function of KDM1B (Lysine-specific Demethylase 1B) is still poorly characterized. This study employed integrated bioinformatics and experimental approaches to investigat...
Functional Role of ALKBH5 in Kidney Injury: Insights Into Mechanisms and Therapeutic Potential [0.03%]
ALKBH5在肾脏损伤中的功能作用：机制及治疗潜力的启示
YiFeng Dong,Danqin Lu,Yiling Wei et al.
YiFeng Dong et al.
ALKBH5, as an m6A demethylase, plays a crucial regulatory role in various kidney diseases such as acute kidney injury, chronic kidney disease, renal fibrosis and renal cell carcinoma. However, its function often exhibits contradictory effec...
Notoginsenoside R1 Alleviates Macrophage Inflammatory Responses via Modulating the JAK1/STAT3 Pathway [0.03%]
诺神肽R1通过调节JAK1/STAT3信号通路缓解巨噬细胞炎症反应
Chengjie Wu,Shuting Hou,Meizhi Liu et al.
Chengjie Wu et al.
Notoginsenoside R1 (NR1), an active component of Panax notoginseng, may exert anti-atherosclerotic effects by modulating macrophage M1/M2 polarization. This study aimed to investigate the specific mechanism of NR1 against atherosclerosis ba...
Novel Endocrine Signaling Axis in Cardiovascular-Kidney-Metabolic Syndrome: Interactions and Therapeutic Potential of FGF21 and GDF15 [0.03%]
心血管-肾脏-代谢综合征新内分泌轴信号通路及其FGF21和GDF15的相互作用及治疗潜力研究进展
Changlong Yang,Lei Chen,Hong Xiao et al.
Changlong Yang et al.
Cardiovascular-Kidney-Metabolic Syndrome (CKM) is a multisystem disorder characterized by interdependent cardiovascular, renal, and metabolic dysfunction. It commonly involves metabolic conditions such as type 2 diabetes and obesity and is ...
RETRACTION: Neuroprotective Effect of Licochalcone a Against Oxygen-glucose Deprivation/Reperfusion in Rat Primary Cortical Neurons by Attenuating Oxidative Stress Injury and Inflammatory Response via the SIRT1/Nrf2 Pathway [0.03%]
撤稿：甘草黄酮a通过SIRT1/Nrf2通路减弱氧化应激损伤和炎症反应在大鼠皮质神经元中对抗氧糖剥夺/再灌注的神经保护作用
X. Liu, Y. Ma, X. Wei, and T. Fan, "Neuroprotective Effect of Licochalcone a Against Oxygen-glucose Deprivation/Reperfusion in Rat Primary Cortical Neurons by Attenuating Oxidative Stress Injury and Inflammatory Response via the SIRT1/Nrf2 ...
Glucose Metabolism in Immune Regulation: From Mechanisms to Therapeutic Opportunities [0.03%]
糖代谢在免疫调节中的作用：从机制到治疗机遇
Takhellambam Malemnganba,Anurag Kumar Pandey,Sramona Kar et al.
Takhellambam Malemnganba et al.
Immune cell activation and differentiation are tightly coupled to metabolic reprogramming, with glucose availability and intracellular glycolytic flux serving as central determinants of immune cell fate and function. While increased glucose...
Therapeutic Effect of Parthenolide on Paclitaxel-Induced Cardiotoxicity in Rats [0.03%]
白杨素对紫杉醇致大鼠心肌毒性的影响作用研究
Ufuk Kuşkun,Emine Toraman,Enver Fehim Koçpınar et al.
Ufuk Kuşkun et al.
The aim of this study was to investigate the therapeutic effects of parthenolide (PTL), the active constituent of Tanacetum parthenium, on paclitaxel (PTX)-induced cardiotoxicity at both gene and protein expression levels. 48 male Sprague-D...