MiR-145 inhibits the migration and invasion of papillary thyroid carcinoma cells through NF-κB pathway regulation [0.03%]
miR-145通过调节NF-κB途径抑制乳头状甲状腺癌细胞的迁移和侵袭
Gengyu Chen,Ying Gao,Gangpu Wang et al.
Gengyu Chen et al.
Papillary thyroid carcinoma (PTC) is the most prevalent cancer in the endocrine system, and the number of patients diagnosed with PTC has been increasing rapidly in recent years. Previous studies have reported that miR-145 plays an importan...
Long noncoding RNA BHLHE40-AS1 promotes early breast cancer progression through modulating IL-6/STAT3 signaling [0.03%]
长链非编码RNA BHLHE40-AS1通过调节IL-6/STAT3信号促进乳腺癌早期进展
Rebecca S DeVaux,Ali S Ropri,Sandra L Grimm et al.
Rebecca S DeVaux et al.
Ductal carcinoma in situ (DCIS) is a nonobligate precursor to invasive breast cancer. Only a small percentage of DCIS cases are predicted to progress; however, there is no method to determine which DCIS lesions will remain innocuous from th...
Exploring the binding mechanism of HDAC8 selective inhibitors: Lessons from the modification of Cap group [0.03%]
组蛋白去乙酰化酶8选择性抑制剂的结合机制研究及帽结构改造启示
Min Zhang,Jun Biao Ying,Song Song Wang et al.
Min Zhang et al.
The abnormal expression of histone deacetylase 8 (HDAC8) has been reported to associate with various cancer entities (colon, breast cancer, pancreas, etc.) as well as parasitic diseases, making HDAC8 gradually develop into an attractive and...
Downregulation of microRNA-101-3p participates in systemic lupus erythematosus progression via negatively regulating HDAC9 [0.03%]
microRNA-101-3p下调通过抑制HDAC9参与系统性红斑狼疮的发病发展过程
Huanxia Sun,Fei Guo,Liming Xu
Huanxia Sun
This study aimed to investigate the mechanism of microRNA-101-3p (miR-101-3p) on the progression of systemic lupus erythematosus (SLE). The human peripheral blood mononuclear cells (PBMCs) were isolated from whole blood samples of SLE patie...
miR-133a-3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer [0.03%]
miR-133a-3p/FOXP3轴调控胃癌细胞增殖及自噬的功能研究
Jia-Peng Li,Hui-Min Zhang,Mei-Jun Liu et al.
Jia-Peng Li et al.
Although many methods and new therapeutic drugs have been developed, the overall survival rate and long-term survival rate of patients with gastric cancer (GC) are still not satisfactory. In this study, we investigated the effects of microR...
Retracted: Intermedin attenuates cardiomyocytes hypoxia-injury through upregulating long noncoding RNA MALAT1 [0.03%]
撤回：通过上调长链非编码RNA MALAT1来缓解心肌细胞缺氧损伤的中间素的作用
Retraction: 'Intermedin attenuates cardiomyocytes hypoxia-injury through upregulating long noncoding RNA MALAT1', by Long Liu, Haiming Xu, Jingze Zhang, Liquan Yin, Qini Zhao, J Cell Biochem. 2020 (Online Version of Record before inclusion ...
Circular RNA circ-EGLN3 promotes renal cell carcinoma proliferation and aggressiveness via miR-1299-mediated IRF7 activation [0.03%]
circ-EGLN3通过miR-1299介导的IRF7激活促进肾细胞癌的增殖和恶性行为
Ling Lin,Jianhua Cai
Ling Lin
Renal cell carcinoma (RCC) is a highly lethal cancer with increasing incidence worldwide. The purpose of the present study was to investigate the functions and molecular mechanisms of circular RNA (circRNA), circ-EGLN3, in RCC progression. ...
Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer [0.03%]
长链非编码RNA LINC01234通过miR-1284/TRAF6轴促进结直肠癌细胞增殖和侵袭
Xin Liao,Wei Zhan,Jiandong Zhang et al.
Xin Liao et al.
Colorectal cancer is one of the most common and leading malignancies globally. Long noncoding RNAs (lncRNAs) function as potentially critical regulator in colorectal cancer. LINC01234, a novel lncRNA in tumor biology, regulates the progress...
Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway [0.03%]
SMO干扰通过抑制Hh/Gli信号通路增强化疗药物对A2780/DDP细胞的敏感性
Shihong Ma,Dan Liu,Wenhua Tan et al.
Shihong Ma et al.
Aberrant activation of the Hedgehog (Hh)/Gli pathway contributes to the tumorigenesis of several human cancers, including ovarian cancers. We investigated the function of SMO on cell growth, drug resistance, and invasive ability in A2780/DD...
A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population [0.03%]
汉族人群中的一个CHK1功能变异位点增加鼻咽癌发病风险
Zhen Guo,Youhong Wang,Yu Zhao et al.
Zhen Guo et al.
DNA damage checkpoints act as a supervisor by preventing the course of cell cycle upon DNA damage and keeping the steadiness of genome. Checkpoint kinase 1 (CHK1) cannot be ignore in the etiology of numerous human cancers including nasophar...