The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions [0.03%]
星形胶质细胞和神经元的表面共享蛋白质组及它们多细胞相互作用的分子基础
Ling Wu,Vijaya Pandey,Vanessa H Casha et al.
Ling Wu et al.
Neurons and astrocytes are predominant brain cells that extensively interact, but the molecular basis of their interactions remains largely unexplored. We identified and mapped striatal astrocytic and neuronal cell-surface proteins (CSPs) a...
Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning [0.03%]
电压成像揭示了脑桥核中参与血清素能介导的运动活力学习的电路计算过程
Takashi Kawashima,Ziqiang Wei,Ravid Haruvi et al.
Takashi Kawashima et al.
As animals adapt to new situations, neuromodulation is a potent way to alter behavior, yet mechanisms by which neuromodulatory nuclei compute during behavior are underexplored. The serotonergic raphe supports motor learning in larval zebraf...
Adaptive reinforcement learning is causally supported by anterior cingulate cortex and striatum [0.03%]
背侧扣带皮层和纹状体通过因果中介作用支持适应性增强学习
Robert Louis Treuting,Kianoush Banaie Boroujeni,Charles Grimes Gerrity et al.
Robert Louis Treuting et al.
Reinforcement learning can benefit from adaptive strategies that adjust exploration-exploitation levels, leverage working memory, or guide attention toward relevant information. We tested how the anterior cingulate cortex (ACC) and the stri...
Locus coeruleus activation "resets" hippocampal event representations and separates adjacent memories [0.03%]
蓝斑激活可“重置”海马事件表征并分离相邻记忆
David Clewett,Ringo Huang,Lila Davachi
David Clewett
Memories reflect the ebb and flow of experiences, capturing distinct events from our lives. Using a combination of functional magnetic resonance imaging (fMRI), neuromelanin imaging, and pupillometry, we show that arousal and locus coeruleu...
Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency [0.03%]
CXCR4相关原发性免疫缺陷病的结构异常和运动心理发育障碍的起源研究
Giulia Demenego,Sara Mancinelli,Antonella Borreca et al.
Giulia Demenego et al.
Inborn errors of immunity (IEI), as congenital chronic disorders, are often associated with neurobehavioral symptoms, traditionally considered secondary to patient burden. Their origin, however, has yet to be addressed. Here, we found that ...
Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics [0.03%]
R6/2亨廷顿病小鼠脑中的不同分子特征：来自时空转录组学的见解
Mara S Burns,Ricardo Miramontes,Jie Wu et al.
Mara S Burns et al.
Huntington's disease (HD) is marked by widespread cellular dysregulation. To understand disease mechanisms, we and others have utilized bulk and single-cell transcriptomics, which provide cell-type information but limited spatial informatio...
Nadine Dijkstra,Thomas von Rein,Peter Kok et al.
Nadine Dijkstra et al.
Humans are able to imagine scenarios that are decoupled from the current environment by internally activating perceptual representations. Although an efficient re-use of existing resources, it remains unknown how human observers classify pe...
Structural and functional basis of mechanosensitive TMEM63 channelopathies [0.03%]
机械敏感性TMEM63通道病的结构和功能基础
Wang Zheng,Augustus J Lowry,Harper E Smith et al.
Wang Zheng et al.
TMEM63A, -B, and -C constitute a mammalian family of mechanosensitive ion channels that are mutated in neurodevelopmental disorders. The molecular mechanisms underlying TMEM63 activation by force and the impact of disease-associated mutatio...
Cristina M Alberini
Cristina M Alberini
Unraveling the cell biology of learning and memory has been a major goal in neuroscience, as memories influence our actions and shape our identities, and many debilitating memory disorders currently lack effective treatments. Early research...
Jessie Axsom,F Chris Bennett
Jessie Axsom
What makes a microglia a microglia? In a recent issue of Cell, Wu et al.1 discover immune cells with microglial gene expression, epigenetic profiles, and ontogeny in the peripheral nervous system of large vertebrates, calling into question ...