20 years of concept cells: From invariant responses to a unique coding of human memory [0.03%]
概念细胞二十年：从不变的反应到人类记忆的独特编码
Rodrigo Quian Quiroga
Rodrigo Quian Quiroga
I discuss human single-neuron recordings and the discovery of concept cells-i.e., neurons representing specific concepts in the hippocampus and surrounding cortex-about 20 years ago. I then present the main properties of concept cells and s...
A touch-guided neural circuit regulates motivated gnawing to maintain dental alignment [0.03%]
一种受控于神经环路的咬合力调节趋食啮咬行为以维持牙齿排列的功能
Xin-Yu Su,Elizabeth A Ronan,Sienna K Perry et al.
Xin-Yu Su et al.
How hindbrain circuits integrate peripheral and central signals to regulate complex oral behaviors is poorly understood. In rodents, gnawing is essential for localized tooth wear to offset lifelong incisor growth. Whether this process relie...
The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective [0.03%]
阿尔茨海默病前期情绪调节视角下的神经精神症状的出现
Adam Turnbull,James J Gross,Feng Vankee-Lin
Adam Turnbull
Preclinical Alzheimer's disease (AD) is associated with distressing neuropsychiatric symptoms (NPSs) that may accelerate progression toward dementia. Existing approaches probe the symptom-level domain-general or domain-specific neural corre...
Regional specialization in prefrontal cortex manifests in the reliability of task progression codes [0.03%]
与任务进程表征可靠性相关的前额叶皮层区域特化
Jennifer A Guidera,Daniel P Gramling,Alison E Comrie et al.
Jennifer A Guidera et al.
The brain has the remarkable ability to guide the performance of complex tasks. Distinct prefrontal cortical areas make specific contributions to this ability, with the orbitofrontal cortex (OFC) critical for processing information related ...
Louis Pezon,Valentin Schmutz,Wulfram Gerstner
Louis Pezon
Dimensionality reduction methods are widely used in neuroscience to investigate two complementary aspects of neural activity: the distribution of single-neuron functional properties and the low-dimensional collective dynamics of population ...
David Sussillo [0.03%]
大卫·萨斯洛
David Sussillo
David Sussillo
In this interview with Neuron, David Sussillo reflects on his journey from a disadvantaged childhood to becoming a leading computational neuroscientist and AI researcher. He discusses the development of FORCE learning, advances in neural ne...
Yulan Li,Yibei Wang,Lixuan Li et al.
Yulan Li et al.
Anxiety disorders are the most prevalent mental disorders globally, yet current treatments remain limited. Histamine is an evolutionarily conserved neuromodulator recently implicated in neuropsychiatric disorders. However, whether and how h...
20 lessons in team science: Learning from the experience of the International Brain Laboratory [0.03%]
团队科学研究的二十堂课——从国际脑科学实验室计划中吸取的经验教训
International Brain Laboratory. Electronic address: info@internationalbrainlab.org;Hannah M Bayer,Daniel Birman,Gaelle Chapuis et al.
International Brain Laboratory. Electronic address: info@internationalbrainlab.org;Hannah M Bayer et al.
Leveraging large-scale neuroscience datasets requires new collaborative approaches. The International Brain Laboratory (IBL) is a distributed, open-science experiment facing these challenges. To succeed, IBL developed methods for shared dec...
Rethinking neuroaesthetics: Toward a multidimensional and integrative science of aesthetic experience [0.03%]
反思神经美学：朝向审美体验的多维度整合科学
Yi Lin,Johan Wagemans,Hans Op de Beeck
Yi Lin
We propose a multidimensional framework for neuroaesthetics that combines an experimental characterization of dimensions with multivariate analyses, tracing how sensory input is transformed over time through perceptual, semantic, and affect...
From syllables to states: Hierarchical organization of self-motivated behavior across brain circuits [0.03%]
从音节到状态：动机行为的脑机制及其层级组织规律
Irene Lenzi,Simon Musall
Irene Lenzi
Weinreb et al.1 show that spontaneous behavior is hierarchically organized into self-motivated states and reusable action syllables. While the prefrontal cortex primarily encodes behavioral states, the dorsolateral striatum governs action s...