Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling [0.03%]
区域映射的星形胶质细胞对皮层和白质卒中的反应显示其在诱导血管重塑方面的作用不同
Amy J Gleichman,Riki Kawaguchi,Elle M Rathbun et al.
Amy J Gleichman et al.
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue repair are poorly understood, particularly across brain regions and stroke subtypes. We i...
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis [0.03%]
整合组学揭示多发性硬化症中与疾病相关的放射状胶质细胞样细胞的表观遗传干扰素反应失调
Bongsoo Park,Alexandra M Nicaise,Dimitrios Tsitsipatis et al.
Bongsoo Park et al.
Progressive multiple sclerosis (PMS) involves a persistent, maladaptive inflammatory process with numerous cellular drivers. We generated induced neural stem cells (iNSCs) from patient fibroblasts through a direct reprogramming protocol tha...
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders [0.03%]
中性粒细胞胞外陷阱中的LCN2诱导星形胶质细胞活化及脑卒中后情绪障碍
Yuan Liu,Wei Lin,Zhongfei Bai et al.
Yuan Liu et al.
Patients with an ischemic stroke are often predisposed to emotional disorders. However, the mechanisms underlying post-stroke emotional disorders (PSEDs) remain unclear. Recent research highlights the role of neuroinflammation, driven prima...
Kyle A Brown,Musa I Ajibola,Gustavo C Medeiros et al.
Kyle A Brown et al.
Recent antidepressant drug development focuses on a next generation of drugs to rapidly relieve symptoms. Yet, how ketamine, the prototype rapid-acting antidepressant, maintains symptom relief days after drug elimination, and how repeated d...
Restoration of temporal separability between beta and movement ensemble co-firing with motor recovery [0.03%]
运动恢复过程中β频段节律与运动神经元簇发放之间时序解耦关系的重塑规律研究
Hoseok Choi,Jaekyung Kim,Preeya Khanna et al.
Hoseok Choi et al.
Stroke disrupts movement control by damaging descending motor pathways, yet the cortical dynamics underlying recovery remain poorly defined. Using a non-human primate model of primary motor cortex injury with impaired reach-to-grasp control...
Giacomo Indiveri
Giacomo Indiveri
In this NeuroView, Giacomo Indiveri discusses the origins and evolution of neuromorphic engineering, reflects on recent shifts toward digital and AI-centric approaches, and advocates for a revival of the field's original principles, emphasi...
Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer's disease model mice [0.03%]
隔裂的背内侧下丘脑-齿状回环路调节健康和阿尔茨海默病模型小鼠的认知及情感功能
Yan-Jia Luo,Longfei Li,Ze-Ka Chen et al.
Yan-Jia Luo et al.
While progressive cognitive decline is the defining feature of Alzheimer's disease (AD), many patients also develop prominent neuropsychiatric symptoms, including anxiety and depression. The circuit-level mechanisms underlying these distinc...
Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila [0.03%]
一种名为Vulnusin的肽的鉴定：这种肽是果蝇机械损伤诱导伤害感受的伤口信号分子
Yanmeng Guo,Tun Li,Sami T Tuomivaara et al.
Yanmeng Guo et al.
Animals can acutely sense a puncture or cut in their skin through nociceptors. However, the molecular identity of such "wound signals" and their receptors on nociceptors remains unknown. In Drosophila larvae, class IV dendritic arborization...
SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesis [0.03%]
全基因组eQTL分析揭示远距离增强子网络在人类皮层神经发生中的作用
Lumeng Jia,Yingping Hou,Zejia Cui et al.
Lumeng Jia et al.
Chromatin in the human brain cortex shows more enhancer-enhancer contacts than in macaques and mice, yet the organization of these contacts across cellular states and the mechanisms behind them remain unclear. Here, we developed simultaneou...
Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain [0.03%]
海马涟漪的多样性组织了离线大脑中的神经元重新激活动力学
Manfredi Castelli,Vítor Lopes-Dos-Santos,Giuseppe P Gava et al.
Manfredi Castelli et al.
Hippocampal ripples are highly synchronized neuronal population patterns reactivating past waking experiences in the offline brain. Whether the level, structure, and content of ripple-nested activity are consistent across consecutive events...