Divergent somatic mutation patterns among human cerebellar neuron types [0.03%]
人小脑神经元类型的体细胞突变谱模式差异性
Marta Grońska-Pęski,Amoolya Srinivasa,Gilad D Evrony
Marta Grońska-Pęski
Neurons accumulate somatic mutations with age, but how mutation processes vary among neuronal types remains unclear. Characterizing this variability may elucidate the role of genome integrity in brain function and disease and reveal determi...
Wade G Regehr,Evan Z Macosko,Court A Hull
Wade G Regehr
For decades, the cerebellar cortex was viewed as a simple circuit comprised of repeated modules containing only a few basic cell types. However, discoveries made possible by modern molecular and physiological approaches have challenged this...
Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis [0.03%]
衰老和多发性硬化症中代谢的时序变化引导少突胶质前体细胞动态变化
Tess Dierckx,Sarah E Wilson,Rebecca Buchanan et al.
Tess Dierckx et al.
Impaired oligodendrocyte precursor cell (OPC) differentiation limits myelin renewal in aging and contributes to multiple sclerosis (MS) progression. How aging drives OPC deficits remains incompletely understood. We find dysregulation of gen...
Early-life stress alters H3K4me1 in VTA to prime stress sensitivity [0.03%]
早期生活压力会改变中脑腹侧被盖区H3K4me1从而提高应激敏感性
Hye Ji J Kim,Luke T Geiger,Julie-Anne Balouek et al.
Hye Ji J Kim et al.
Early-life stress increases gene expression, neurophysiological, and behavioral responses to subsequent stress. Here, we determined the role of chromatin in such long-lasting sensitivity. We used a combination of bottom-up mass spectrometry...
Inferring brain-wide interactions using data-constrained recurrent neural network models [0.03%]
基于数据约束的递归神经网络模型推断全脑相互作用
Matthew G Perich,Charlotte Arlt,Sofia Soares et al.
Matthew G Perich et al.
Behavior arises from the coordinated activity across anatomically and functionally distinct brain regions. Modern experimental tools allow unprecedented access to large neural populations spanning many interacting regions brain-wide. Yet, u...
Deep learning-based control of electrically evoked activity in human visual cortex [0.03%]
基于深度学习的人类视觉皮层电刺激反应控制
Pehuén Moure,Jacob Granley,Fabrizio Grani et al.
Pehuén Moure et al.
Visual cortical prostheses offer a promising path to sight restoration, but current systems elicit crude, variable percepts and rely on manual electrode-by-electrode calibration that does not scale. These limitations reflect a deeper challe...
Tau-induced mitochondrial reverse electron transport drives neurodegeneration [0.03%]
tau诱发的线粒体逆向电子传递驱动神经退行性病变
Wen Li,Suman Rimal,Sunil Bhurtel et al.
Wen Li et al.
Hyperphosphorylation and aggregation of tau are pathological hallmarks of tauopathies. Mitochondrial dysfunction is also a common feature of tauopathies. The mechanistic link between tau abnormalities and mitochondrial dysfunction and its r...
Lanxia Meng,Congcong Liu,Huangchuan Gong et al.
Lanxia Meng et al.
Protein misfolding and propagation contribute to neurodegenerative diseases. Recently, cryogenic electron microscopy of insoluble amyloid fibrils derived from individuals with frontotemporal lobar degeneration (FTLD) revealed new species of...
Simultaneous, real-time tracking of many neuromodulatory signals with multiplexed optical recording of sensors on a micro-endoscope [0.03%]
基于微内窥镜的多路复用光学传感器技术实现多种神经调质信号的同时实时追踪
Peter N Kalugin,Paul A Soden,Crystian I Massengill et al.
Peter N Kalugin et al.
Dozens of extracellular molecules jointly impact a given brain cell, yet we lack methods to simultaneously record many such signals in real time. We developed a probe to track ten or more neuropeptide and neuromodulator concentrations using...
Nadine Dijkstra,Giulia Cabbai
Nadine Dijkstra
By systematically characterizing subjective experience during mental imagery, Anderson et al. demonstrate neural overlap between imagery and perception in transmodal association networks. These results raise fundamental and exciting new que...