Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development [0.03%]
人特有的SRGAP2同源物同步化新生儿小胶质细胞成熟和突触发育
Carlos Diaz-Salazar,JaeYeon Kim,Marine Krzisch et al.
Carlos Diaz-Salazar et al.
The human brain is distinguished by unusually prolonged developmental timing, yet the genetic mechanisms coordinating this neoteny across cell types remain incompletely understood. Here, we show that human cortical microglia undergo neoteni...
A sync state in the midbrain dopamine network for interoceptive nutrient learning [0.03%]
中脑多巴胺神经元网络的同步状态调节内感受性营养学习
Xiao Yang,Weijie Yan,Weixuan Lu et al.
Xiao Yang et al.
Gastrointestinal nutrient signals, arriving minutes after eating, powerfully reinforce food intake. How the brain links these delayed interoceptive signals to immediate sensory cues remains unclear. We show that ventral tegmental area (VTA)...
Neurexin-1γ drives synaptic transmission through structural integration of neurotransmitter release machinery and postsynaptic receptor nanodomains [0.03%]
Neurexin-1γ通过神经递质释放机器和突触后受体纳米结构的结构整合来驱动突触传递
Nirmala Padmanabhan,Rebecca E Twilley,Shinichiro Oku et al.
Nirmala Padmanabhan et al.
Synaptic transmission requires precise nanoscale alignment of presynaptic release machinery and postsynaptic receptor nanodomains. However, the molecular links bridging these subsynaptic elements remain unresolved. We identify mammalian neu...
Vladislav Ayzenberg,Michael F Bonner,Laurie Bayet
Vladislav Ayzenberg
The goal of artificial intelligence (AI) modeling in neuroscience, or NeuroAI, is to uncover the factors that give rise to human-level intelligence. However, current models overwhelmingly focus on simulating adulthood, the end state of inte...
Neural traveling waves in cortex: Network mechanisms and potential roles in neural computation [0.03%]
皮层神经 traveling waves：网络机制及其在神经计算中的潜在作用
Lyle Muller,Alexandra N Busch,Zachary W Davis et al.
Lyle Muller et al.
First discovered in anesthetized animals, neural traveling waves (nTWs) have now been observed throughout the brains of awake animals, where they influence neural excitability and behavior. nTWs can arise intrinsically in ongoing network ac...
Senescent cell heterogeneity in brain aging and neurodegenerative disease [0.03%]
大脑衰老和神经退行性疾病中的衰老细胞异质性
Sara I Graves,Pedro Versuti Del Cioppo Vasques,Darren J Baker
Sara I Graves
Senescent cells in the aging and diseased brain are increasingly recognized as highly heterogeneous catalysts of dysfunction, originating from diverse cell types and characterized by wide-ranging molecular signatures and functional outcomes...
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development [0.03%]
DISC1常见多态性可干扰Wnt/GSK3β信号通路及脑发育
Karun K Singh,Gianluca De Rienzo,Laurel Drane et al.
Karun K Singh et al.
Published Erratum
Neuron. 2026 Jul 18:S0896-6273(26)00483-6. DOI:10.1016/j.neuron.2026.06.015 2026
Optogenetic mimicry of drug action: Tools and models to dissect the dopamine-dependent core of addiction [0.03%]
光遗传学模仿药物作用：用于解剖成瘾的多巴胺依赖核心的工具和模型
Christian Lüscher,Laurena Python,Yu Liu et al.
Christian Lüscher et al.
Drug addiction is characterized by compulsive drug use despite negative consequences, reflecting maladaptive changes in brain circuits. Elucidating the underlying neural mechanisms relies on animal models that capture core features of the d...
Phillip Bokiniec,Clarissa J Whitmire,James F A Poulet
Phillip Bokiniec
Innocuous temperature sensation arises from the activity of primary afferent thermoreceptors, but how these neurons encode cool and warm at the population level remains unclear. Using two-photon in vivo imaging of the L4 dorsal root ganglio...
Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex [0.03%]
幼鼠双眼视觉皮层的临界期行为学习重塑突触基准点
Diane Bissen,Brian A Cary,Amanda Zhang et al.
Diane Bissen et al.
Critical periods are developmental windows that allow experience-dependent refinement of neuronal circuitry and function. While the consequences of sensory deprivation or alteration during the visual critical period have been well character...