Timothy L Frankel,Marina Pasca di Magliano
Timothy L Frankel
The microbiome affects establishment and growth of tumors as well as response to immune-based therapies. In this issue of Immunity, Hezaveh et al. (2022) reveal that metabolites of dietary tryptophan generated by the gut microbiota activate...
Ursula Smole,Hamida Hammad
Ursula Smole
The causal signals and the relevance of group 2 innate lymphoid cell (ILC2) dynamic redistribution during inflammation remain unknown. In this issue of Immunity, Cautivo et al. show that type 2 immunity drives ILC2 accumulation at non-adven...
Hui-Fern Koay,Nicholas A Gherardin,Thi H O Nguyen et al.
Hui-Fern Koay et al.
Petter Brodin
Petter Brodin
SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all be...
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers [0.03%]
Tbeth和CD11c表达B细胞的发育需要生发中心外的滤泡辅助T细胞
Wenzhi Song,Olivia Q Antao,Emily Condiff et al.
Wenzhi Song et al.
Tbet+CD11c+ B cells arise during type 1 pathogen challenge, aging, and autoimmunity in mice and humans. Here, we examined the developmental requirements of this B cell subset. In acute infection, T follicular helper (Tfh) cells, but not Th1...
mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern [0.03%]
针对SARS-CoV-2关切变异株mRNA-1273疫苗诱导的抗体仍保持效应子功能
Paulina Kaplonek,Stephanie Fischinger,Deniz Cizmeci et al.
Paulina Kaplonek et al.
SARS-CoV-2 mRNA vaccines confer robust protection against COVID-19, but the emergence of variants has generated concerns regarding the protective efficacy of the currently approved vaccines, which lose neutralizing potency against some vari...
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells [0.03%]
生理性CXCR5hiPD-1hi滤泡辅助T细胞是一个生理上独特的生发中心驻留初始型滤泡辅助T细胞亚群
Chen-Hao Yeh,Joel Finney,Takaharu Okada et al.
Chen-Hao Yeh et al.
T follicular helper (Tfh) cells are defined by a Bcl6+CXCR5hiPD-1hi phenotype, but only a minor fraction of these reside in germinal centers (GCs). Here, we examined whether GC-resident and -nonresident Tfh cells share a common physiology a...
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment [0.03%]
IL-17RA信号通过Lgr5+肠道干细胞诱导转录因子ATOH1的表达以促进分泌细胞系谱的决定
Xun Lin,Stephen J Gaudino,Kyung Ku Jang et al.
Xun Lin et al.
The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is expressed by diverse intestinal cell types, and therapies ta...
Stefanie Kreutmair,Burkhard Becher
Stefanie Kreutmair
Xaquin Castro Dopico,Gunilla B Karlsson Hedestam
Xaquin Castro Dopico
The immune response is an amalgam of heritable and non-heritable effects, although the contribution of each is generally unknown. In this issue of Immunity, Venkataraman et al. report heritable traits that govern anti-viral antibody epitope...