Florent Ginhoux,Adam Yalin,Charles Antoine Dutertre et al.
Florent Ginhoux et al.
The immune system is a complex, dynamic, and plastic ecosystem composed of multiple cell types that constantly sense and interact with their local microenvironment to protect from infection and maintain homeostasis. For over a century, grea...
Vijay K Kuchroo,Howard L Weiner
Vijay K Kuchroo
Epstein-Barr virus (EBV) is a putative trigger for multiple sclerosis (MS), but clear causality is lacking. In a recent issue of Science, Bjornevik and Cortese et al. utilize longitudinal evaluation of over 10 million adults to demonstrate ...
Xihao Hu,X Shirley Liu
Xihao Hu
In this issue of Immunity, Meylan et al. (2022) uses spatial transcriptomics to examine B cell immunity within intratumoral tertiary lymphoid structures (TLSs). They find that B cells expand and mature into plasma cells (PCs) within the TLS...
Yuke He,Carola G Vinuesa
Yuke He
Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et...
Shelly J Robertson,Sonja M Best
Shelly J Robertson
Macrophage activation is essential for effective immunity to infection but can also contribute to disease through incompletely understood mechanisms. In this issue of Immunity, Simpson et al. reveal that death of activated macrophages integ...
Gary Reynolds,Alice Tirard,Alexandra-Chloé Villani
Gary Reynolds
The presumed common origin of plasmacytoid and conventional dendritic cells has been the contentious subject of recent debate. In this issue of Immunity, Feng et al. employed an inducible cell barcoding system to track clonal relationships ...
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer [0.03%]
三级淋巴器官在肾细胞癌中生成和传播产生抗肿瘤抗体的浆细胞
Maxime Meylan,Florent Petitprez,Etienne Becht et al.
Maxime Meylan et al.
The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial transcriptomics to examine the nature of B cell responses within T...
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection [0.03%]
在慢性病毒感染期间，Tfh细胞源的白介素21维持效应CD8⁺T细胞反应
Ryan Zander,Moujtaba Y Kasmani,Yao Chen et al.
Ryan Zander et al.
CD4+ T cell-derived interleukin 21 (IL-21) sustains CD8+ T cell responses during chronic viral infection, but the helper subset that confers this protection remains unclear. Here, we applied scRNA and ATAC-seq approaches to determine the he...
Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [0.03%]
细菌感染通过单核细胞募集和代谢适应受损破坏生发中心反应
Adi Biram,Jingjing Liu,Hadas Hezroni et al.
Adi Biram et al.
Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary...
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells [0.03%]
克隆系谱追踪揭示了经典型和浆细胞样树突状细胞的起源相同
Jue Feng,Joseph N Pucella,Geunhyo Jang et al.
Jue Feng et al.
Developmental origins of dendritic cells (DCs) including conventional DCs (cDCs, comprising cDC1 and cDC2 subsets) and plasmacytoid DCs (pDCs) remain unclear. We studied DC development in unmanipulated adult mice using inducible lineage tra...