Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation [0.03%]
自然杀伤细胞发育和T辅助-1细胞分化过程中转录因子T-bet诱导的差异调节机制研究
Difeng Fang,Kairong Cui,Yaqiang Cao et al.
Difeng Fang et al.
Adaptive CD4+ T helper cells and their innate counterparts, innate lymphoid cells, utilize an identical set of transcription factors (TFs) for their differentiation and functions. However, similarities and differences in the induction of th...
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches [0.03%]
I型常规树突状细胞维持并引导耗竭性T细胞前体在不同细胞生态位的分化
Sabrina Dähling,Ana Maria Mansilla,Konrad Knöpper et al.
Sabrina Dähling et al.
Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T (Tpex) cells, but the local anatomical context of their maintenance, differentiation, and interplay with other...
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer [0.03%]
肠道微生物激活髓系细胞的钙调磷酸酶-NFAT通路可抑制肠癌中的B7H3和B7H4依赖性抗肿瘤免疫
Kenneth Peuker,Anne Strigli,Daniele V F Tauriello et al.
Kenneth Peuker et al.
Bacterial sensing by intestinal tumor cells contributes to tumor growth through cell-intrinsic activation of the calcineurin-NFAT axis, but the role of this pathway in other intestinal cells remains unclear. Here, we found that myeloid-spec...
Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors [0.03%]
谱系示踪和单细胞测序揭示淋巴结基质前体的起源及多样性
Elisa Lenti,Luca Genovese,Silvia Bianchessi et al.
Elisa Lenti et al.
Lymph node (LN) stromal cells play a crucial role in LN development and in supporting adaptive immune responses. However, their origin, differentiation pathways, and transcriptional programs are still elusive. Here, we used lineage-tracing ...
Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites [0.03%]
二次流感感染触发定居记忆B细胞迁移并快速定位以增强感染部位的抗体分泌
Andrew J MacLean,Niamh Richmond,Lada Koneva et al.
Andrew J MacLean et al.
Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice and humans; however, their contribution to recall responses has not been defined. Here, we used two-photon microscopy to visualize BRM cells within th...
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine [0.03%]
肠毛Tuft-2细胞通过感知细菌代谢物N-十一烷酰甘氨酸来发挥抗菌免疫作用
Zhen Xiong,Xiaoxiao Zhu,Jingjing Geng et al.
Zhen Xiong et al.
Tuft cells are a type of intestinal epithelial cells that exist in epithelial barriers and play a critical role in immunity against parasite infection. It remains insufficiently clear whether Tuft cells participate in bacterial eradication....
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones [0.03%]
单细胞多组学揭示HIV-1在扩增的细胞毒性T细胞克隆中持续存在
Jack A Collora,Runxia Liu,Delia Pinto-Santini et al.
Jack A Collora et al.
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface protein expression, cellular transcriptome, HIV-1 RNA, and TC...
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers [0.03%]
人类表观遗传和转录T细胞分化图谱，用于识别功能特异性T细胞增强子
Josephine R Giles,Sasikanth Manne,Elizabeth Freilich et al.
Josephine R Giles et al.
The clinical benefit of T cell immunotherapies remains limited by incomplete understanding of T cell differentiation and dysfunction. We generated an epigenetic and transcriptional atlas of T cell differentiation from healthy humans that in...
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses [0.03%]
TIGIT和PD-1抑制途径的机制趋同需要联合阻断以优化抗肿瘤CD8+T细胞反应
Karl L Banta,Xiaozheng Xu,Avantika S Chitre et al.
Karl L Banta et al.
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate anti-tumor CD8+ T cells. Although PD-1 and T...
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts [0.03%]
T细胞来源的白细胞介素22在结肠隐窝抗细菌防御中的非冗余作用
Carlene L Zindl,Steven J Witte,Vincent A Laufer et al.
Carlene L Zindl et al.
Interleukin (IL)-22 is central to immune defense at barrier sites. We examined the contributions of innate lymphoid cell (ILC) and T cell-derived IL-22 during Citrobacter rodentium (C.r) infection using mice that both report Il22 expression...