Carl Nathan
Carl Nathan
Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and long forms. Our understanding of inflammation is rapidly evolving. Like the immune system of which it is a part, inflammation can now be seen as an ...
Rossana Azzoni,Benjamin J Marsland
Rossana Azzoni
The gut microbiome is well-known to shape local and distal immune responses, both in health and disease. In a recent issue of Nature, Hosang et al. demonstrate how the lung microbiome regulates the magnitude of autoimmune inflammation in th...
Daniel H Cho,Gloria B Choi
Daniel H Cho
The impact of intestinal fungi on host physiology and their mechanisms of interaction are incompletely understood. In a recent issue of Cell, Leonardi et al. (2022) showed that mucosal fungi induce intestinal Th17 cells to produce IL-22 and...
Amélie Lopès,Romina S Goldszmid
Amélie Lopès
Immune checkpoint blockade has dramatically improved cancer therapy but remains ineffective for most colorectal tumors. In this issue of Immunity, Peuker et al. describe a microbiota-myeloid-tumor cell crosstalk that inhibits CD8+ T cells a...
Mira A Patel,Sohail F Tavazoie
Mira A Patel
Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo et al. identify RIPK1 as an interferon-stimulated gene with potent effect...
David G Brooks,Pamela S Ohashi
David G Brooks
Responsiveness to PD-1 blockade depends on a cell subset known as Tpex cells, but how these cells are sustained is less understood. In this issue of Immunity, Dähling et al. show how dendritic cells form a niche for Tpex preservation. ...
Heike C Hawerkamp,Padraic G Fallon
Heike C Hawerkamp
Epithelial cells (tuft and goblet cells) interact with immune cells on the "inside" while secreting effector molecules into the topological "outside." In this issue of Immunity, Zhao et al. investigate an interleukin-33 (IL-33) secretion me...
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity [0.03%]
LAG-3与稳定肽-MHC II类分子的结合限制T细胞的功能并抑制自身免疫和抗癌免疫
Takumi Maruhashi,Daisuke Sugiura,Il-Mi Okazaki et al.
Takumi Maruhashi et al.
Lymphocyte activation gene-3 (LAG-3) is a potent inhibitory co-receptor; yet, its functional ligand remains elusive, with distinct potential ligands identified. Here, we investigated the relative contribution of potential ligands, stable pe...
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2 [0.03%]
一项大规模系统调查显示SARS-CoV-2公共抗体反应中存在反复出现的分子特征
Yiquan Wang,Meng Yuan,Huibin Lv et al.
Yiquan Wang et al.
Global research to combat the COVID-19 pandemic has led to the isolation and characterization of thousands of human antibodies to the SARS-CoV-2 spike protein, providing an unprecedented opportunity to study the antibody response to a singl...
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C [0.03%]
上皮STAT6糖基化驱动依赖于刷状细胞增殖和Gasdermin C的协同抗寄生虫警报素反应
Ming Zhao,Kaiqun Ren,Xiwen Xiong et al.
Ming Zhao et al.
The epithelium is an integral component of mucosal barrier and host immunity. Following helminth infection, the intestinal epithelial cells secrete "alarmin" cytokines, such as interleukin-25 (IL-25) and IL-33, to initiate the type 2 immune...