SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection [0.03%]
未接种疫苗但在感染后产生血清学反应的儿童中建立了具有共同T细胞受体(TCR)αβ构型的记忆T细胞应对SARS-CoV-2
Louise C Rowntree,Thi H O Nguyen,Lukasz Kedzierski et al.
Louise C Rowntree et al.
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 children and adults to define their circulating memory SA...
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis [0.03%]
极低密度脂蛋白受体增强的胰星状细胞脂质代谢促进胰腺纤维化
Xuguang Yang,Jie Chen,Jun Wang et al.
Xuguang Yang et al.
Lipoprotein disorder is a common feature of chronic pancreatitis (CP); however, the relationship between lipoprotein disorder and pancreatic fibrotic environment is unclear. Here, we investigated the occurrence and mechanism of pancreatic s...
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization [0.03%]
肠道微生物定植后，小肠常驻嗜酸性粒细胞维持肠道稳态
Aline Ignacio,Kathleen Shah,Jeremiah Bernier-Latmani et al.
Aline Ignacio et al.
The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the lengt...
Big fish in small ponds: Narrow repertoires of stem-like tissue-resident T cells yield great power in anti-tumor immunity [0.03%]
小池大魚：類干細胞組織駐留T細胞的小范圍譜系在抗腫瘤免疫中作用巨大
Kellie N Smith
Kellie N Smith
Metastatic ovarian cancer is a significant clinical challenge due in part to its poor response to immunotherapy. In a recent issue of Cancer Cell, Anandon et al. (2022) identify a population of stem-like tissue-resident memory T cells that ...
Kai Markus Schneider,Christoph A Thaiss
Kai Markus Schneider
The microbiome modulates brain function, but the precise routes of gut-brain communication remain unclear. In a recent issue of Science, Gabanyi et al. discover that hypothalamic GABAergic neurons directly recognize microbial muropeptides v...
Nicoletta Caronni,Renato Ostuni
Nicoletta Caronni
In this issue of Immunity, Eisenstein, Hiliard, et al., uncover a novel mechanism of some widely used non-steroidal anti-inflammatory drugs (NSAIDs): activation of the antioxidant transcription factor NRF2 in myeloid immune cells. ...
Benoît Manfroi,Simon Fillatreau
Benoît Manfroi
Regulatory B cells infiltrate the microenvironment of solid tumors. However, their identification and characterization remain incomplete. In this issue of Immunity, Wang and colleagues characterize a new subset of leucine-induced regulatory...
Mirja Tamara Prentzell,Christiane A Opitz
Mirja Tamara Prentzell
Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signal...
Claudia A Rivera,Ana-Maria Lennon-Duménil
Claudia A Rivera
The relevance of cross-dressing as an antigen presentation mechanism in antitumor responses is not fully understood. In this issue of Immunity, MacNabb et al. (2022) report that dendritic cells use cross-dressing as an effective mechanism t...
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [0.03%]
脂质纳米颗粒通过诱导强大的滤泡辅助T细胞和体液反应来增强mRNA和蛋白质亚单位疫苗的功效
Mohamad-Gabriel Alameh,István Tombácz,Emily Bettini et al.
Mohamad-Gabriel Alameh et al.
Published Erratum
Immunity. 2022 Jun 14;55(6):1136-1138. DOI:10.1016/j.immuni.2022.05.007 2022