Kwat Medetgul-Ernar,Mark M Davis
Kwat Medetgul-Ernar
While inbred mice have informed most of what we know about the immune system in the modern era, they have clear limitations with respect to their ability to be informative regarding genetic heterogeneity or microbial influences. They have a...
Jeffrey Y Zhou,Katherine A Fitzgerald
Jeffrey Y Zhou
During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 prom...
The lung fibroblast as "soil fertilizer" in breast cancer metastasis [0.03%]
肺癌成纤维细胞在乳腺癌转移中的作用："土壤肥料"假说
Julia M Houthuijzen,Karin E de Visser
Julia M Houthuijzen
Fibroblasts strongly impact tumor progression, but whether they prime the pre-metastatic niche is poorly understood. In this issue of Immunity, Gong and Li et al. identify lung-specific immunosuppressive fibroblasts, which are hijacked by b...
Austin Ferro,Lucas Cheadle
Austin Ferro
In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neuron...
Grace M E P Lawrence,Caroline L Holley,Kate Schroder
Grace M E P Lawrence
Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, ignitin...
Indra Bekere,Carina C de Oliveira Mann
Indra Bekere
FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and functional specialization by adopting a head-to-head do...
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein [0.03%]
强有力的抗人副流感病毒抗体通过靶向融合糖蛋白上的多个位点发挥中和及保护作用
C Garrett Rappazzo,Ching-Lin Hsieh,Scott A Rush et al.
C Garrett Rappazzo et al.
Human metapneumovirus (hMPV) is a leading cause of acute lower respiratory tract infections in high-risk populations, yet there are no vaccines or anti-viral therapies approved for the prevention or treatment of hMPV-associated disease. Her...
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages [0.03%]
DNA甲基转移酶3α和TET甲基胞嘧啶双加氧酶2通过抑制线粒体DNA介导的干扰素信号传导限制巨噬细胞的炎症反应
Isidoro Cobo,Tiffany N Tanaka,Kailash Chandra Mangalhara et al.
Isidoro Cobo et al.
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of hematopoietic cells and higher risk of cardiovascular disease (CVD). Here, we invest...
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration [0.03%]
衰老和神经退行性疾病中与疾病相关的微胶质细胞和疾病炎症巨噬细胞的双重发生学起源
Aymeric Silvin,Stefan Uderhardt,Cecile Piot et al.
Aymeric Silvin et al.
Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neur...
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis [0.03%]
转录因子FoxP3可以折叠成两种二聚化状态，对调节性T细胞功能和免疫稳态产生不同的影响
Fangwei Leng,Wenxiang Zhang,Ricardo N Ramirez et al.
Fangwei Leng et al.
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here demonstrated that unlike other k...