Opposing functions of distinct regulatory T cell subsets in colorectal cancer [0.03%]
结直肠癌中不同调节性T细胞亚群的相反功能
Xiao Huang,Dan Feng,Sneha Mitra et al.
Xiao Huang et al.
Enrichment of regulatory T (Treg) cells in solid organ cancers is generally associated with poor prognosis; however, colorectal cancer (CRC) stands out as a notable exception. Here, we examined the heterogeneity of tumoral Treg cells in CRC...
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages [0.03%]
固有型2类淋巴细胞触发肺泡巨噬细胞的炎性转换
Stijn Verwaerde,Jean-François Hastir,Sjoerd T T Schetters et al.
Stijn Verwaerde et al.
Tissue-resident alveolar macrophages (trAMs) safeguard gas exchange by restraining inflammation. Compared with recruited alveolar macrophages (recAMs), trAMs are considered more immunoregulatory and resilient to inflammatory reprogramming. ...
Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation [0.03%]
铁死亡耐受通过促进脂质代谢和病理性2型免疫反应参与过敏性气道炎症病理过程
Chantal Wientjens,Maria Doverman,Jelena Zurkovic et al.
Chantal Wientjens et al.
Type 2 innate lymphoid cells (ILC2s) are essential for maintaining and protecting barrier tissues, but they also drive chronic inflammation, a process associated with altered metabolic activity. Identifying and targeting the metabolic pathw...
The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration [0.03%]
TCR-SUB1-DOCK2轴通过驱动致病性CD4+T细胞组织浸润来促进自身免疫反应
Xiaoxue Li,Wenhua Liang,Weifang Wang et al.
Xiaoxue Li et al.
Aberrant tissue infiltration by activated CD4+ T cells is a central driver of autoimmunity, yet the molecular checkpoints governing antigen-specific T cell ingress remain poorly defined. We found that the transcription factor SUB1 was selec...
Christophe Benoist,Dario A A Vignali,Richard A Flavell et al.
Christophe Benoist et al.
The seminal discoveries that established the role of regulatory T cells in immunological tolerance were recognized by this year's Nobel Prize in Physiology or Medicine. We present here the unfolding of the Treg story, the players involved a...
A surprising link: TET2 clonal hematopoiesis boosts immune checkpoint therapy [0.03%]
意外的联系：TET2克隆造血增强免疫检查点治疗效果
Qiang Dong,Chengcheng Jin
Qiang Dong
TET2 mutations can drive clonal hematopoiesis (CH), but their impact on tumor immunity remains unresolved. Recently in Cancer Cell, Herbrich et al. reported that TET2-mutant CH reprograms tumor-associated macrophages to enhance antigen pres...
Clara Alice Musi,Diego Gomez-Nicola
Clara Alice Musi
The initial responses of microglia to neuronal stress or altered network activity are poorly characterized. Xie and colleagues show that during TDP-43-related neurodegeneration, microglia detect early neuronal hyperactivity and transition i...
Gabrielle R Berman,Carla R Nowosad
Gabrielle R Berman
IgA plasma cells are the most abundant antibody-secreting reservoir in the body, yet details of their origin and behavior remain elusive. In this issue of Immunity, Simons et al. and Siniscalco et al. offer insights into IgA plasma cell dyn...
Brydie R Huckestein,Paul G Thomas
Brydie R Huckestein
Lung-resident memory CD8+ T cells coordinate rapid antiviral defense mechanisms across lung compartments to quicky limit viral replication and spread. In this issue of Immunity, Mattingly et al. demonstrate the importance of CD8+ Trm cell-d...
Skin deep: Unconventional autophagy eats away TNF-driven skin inflammation [0.03%]
浅尝辄止：非经典的自噬清除肿瘤坏死因子驱动的皮肤炎症
Ying Feng,Francis Ka-Ming Chan
Ying Feng
Tumor necrosis factor (TNF), type I interferons (IFNs), and autophagy are important biological processes, but their interactions in inflammation have not been explored. In this issue of Immunity, Priem et al. reveal that ATG9A-mediated auto...