Elizabeth Wickman,Maksim Mamonkin
Elizabeth Wickman
IL-9 is canonically associated with anti-helminth and allergic immunity. However, in this issue of Immunity, Jiang et al. and Castelli et al. demonstrate how integrating IL-9 signaling in T cells enhances their persistence and anti-tumor fu...
David E J Klawon,Tyler Jacks
David E J Klawon
Regulatory T (Treg) cells suppress immune responses and are considered a major barrier to productive anti-tumor immunity. In this issue of Immunity, Huang et al. report that interleukin (IL)-10-producing Treg cells restrain tumor growth by ...
Change and flow [0.03%]
变化与流动
Fabiola V Rivas
Fabiola V Rivas
Nicole Hamagami,Dvita Kapadia,Kia M Barclay et al.
Nicole Hamagami et al.
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging, and disease. Whether these microglial subsets represent ontogenically separate lineag...
Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity [0.03%]
对食蟹猴免疫球蛋白系变异的群体基因组分析揭示了广泛的胚系多样性
Ayelet Peres,Amit A Upadhyay,Vered Klein et al.
Ayelet Peres et al.
Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for ...
Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity [0.03%]
基于免疫标志物的解耦免疫检查点抑制剂的有效性和毒性
Minke W Lucas,Elizabeth M Burton,Petros Dimitriadis et al.
Minke W Lucas et al.
Personalized escalation and de-escalation of immune checkpoint inhibitor (ICI) regimens may help to overcome upfront resistance and mitigate the risk for immune-related adverse events (irAEs). Here, we examined the association between patho...
Hassan Jamaleddine,Bryan T Grenfell,Andrea L Graham et al.
Hassan Jamaleddine et al.
The ability of viruses to adapt and evolve as they spread through a population remains a global concern. Immune responses drive viral evolution, but our understanding of how specific selective pressures from distinct mediators of innate and...
Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation [0.03%]
颅骨骨导管的重塑在神经炎症期间调节免疫细胞进入脑膜
Elisa Eme-Scolan,Michel Gomes,Alessandro Bani et al.
Elisa Eme-Scolan et al.
The meninges, located between the skull and brain, harbor immune cells that monitor the brain borders. Skull marrow communicates with the meninges via bone channels, enabling immune-cell trafficking, but little is known about bone channel f...
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis [0.03%]
转录因子Maf通过促进抑制因子Zeb2的表达来驱动原始造血中微胶质细胞的发展
Jing Chen,Siling Du,Wenxuan Cheng et al.
Jing Chen et al.
Microglia arise exclusively from yolk sac progenitors during primitive hematopoiesis, while other tissue-resident macrophages originate during transient-definitive and definitive hematopoiesis. Macrophage development requires the transcript...
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity [0.03%]
定位并可逆抑制肿瘤周围血管生态位中的CCR7+树突状细胞以塑造癌症免疫性
Beatrice Zitti,Florent Duval,Pratyaksha Wirapati et al.
Beatrice Zitti et al.
Tumor-resident CCR7+ dendritic cells (DCs) are key determinants of antitumor T cell responses. Here, we examined the localization of CCR7+ DCs within tumors and the impact of this positioning on antitumor immunity. Spatial, single-cell, and...