Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation [0.03%]
共生菌-髓系细胞在新生儿皮肤中对话调节白介素-1信号传导和皮肤病理性Th17炎症反应
Miqdad O Dhariwala,Ricardo O Carale,Andrea M DeRogatis et al.
Miqdad O Dhariwala et al.
Early-life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory toward health versus disease. Monocytes, macrophages, and dendritic cells are primary sentinels in barrier tissues, yet the salient contributi...
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages [0.03%]
一类I型干扰素-线粒体轴调节巨噬细胞的促凋亡和干扰素刺激基因的诱导
Gillian Dunphy,Irene Adán-Barrientos,Irene Fernández-Delgado et al.
Gillian Dunphy et al.
Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensing induced a decrease in mitochondrial membrane potential (MMP) while maintaining mitochond...
Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo [0.03%]
可扩展的TCR合成与筛选能够用于绘制白癜风中的抗原反应图谱
Stephanie A Gaglione,Rachit S Mukkamala,Chirag Krishna et al.
Stephanie A Gaglione et al.
T cells initiate targeted immune responses using T cell receptors (TCRs) to recognize specific antigens. Mapping TCRs to antigens at scale remains a major challenge. Here, we developed an approach to synthesize and functionally screen tens ...
Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing [0.03%]
Exosite介导的二聚体颗粒酶A通过淋巴细胞焦亡作用靶向GSDMB
Xiu Zhong,Ya Su,Zhiwei Zhou et al.
Xiu Zhong et al.
In cellular immunity, cytotoxic lymphocytes employ granzyme A (GZMA) to cleave and activate the pore-forming protein gasdermin B (GSDMB) for the pyroptotic killing of target cells. How GZMA recognizes and cleaves GSDMB is unknown. Here, we ...
Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair [0.03%]
肿瘤相关巨噬细胞可促进外周神经肿瘤浸润和脊髓修复
Sissi Dolci,Loris Mannino,Eros Rossi et al.
Sissi Dolci et al.
Tumor-associated macrophages (TAMs) enhance cancer progression by promoting angiogenesis, extracellular matrix remodeling, and immune suppression. Nerve infiltration also contributes to tumor growth. However, the role of TAMs in promoting i...
Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils [0.03%]
细胞因子TL1A激活的固有淋巴样细胞连接结肠炎、应急粒系造血和促肿瘤中性粒细胞募集
Sílvia Pires,Wei Yang,Sofia Frigerio et al.
Sílvia Pires et al.
Inflammatory bowel disease (IBD) increases the risk of colorectal cancer (CRC). Genetic variants in TNFSF15, encoding tumor necrosis factor (TNF)-like cytokine 1A (TL1A), associate with severe IBD and advanced CRC. Here, we investigated how...
Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity [0.03%]
共生菌来源的海藻糖单孢脂诱导γδ T细胞驱动的眼保护屏障免疫响应
Xiaoyan Xu,Yannis E Rigas,Mary J Mattapallil et al.
Xiaoyan Xu et al.
Commensals shape host physiology through molecular crosstalk with host receptors. Identifying specific microbial factors that causally influence host immunity is key to understanding homeostasis at the host-microbe interface and advancing m...
Jasmin Herz,Jonathan Kipnis
Jasmin Herz
Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain's borders. T...
IRF4 sends alveolar macrophages spiraling into an identity crisis during type 2 immunity [0.03%]
IRF4通过类型2免疫使肺泡巨噬细胞身份识别陷入困境
Anika Hutton,Hernandez Moura Silva
Anika Hutton
A long-standing debate in the field asks whether resident tissue macrophages are terminally differentiated or remain capable of changing their fate and function during inflammation. In this issue of Immunity, Verwaerde et al. uncover an IRF...
Jessie Axsom,F Chris Bennett
Jessie Axsom
Ontogeny is a crucial determinant of macrophage function, but it remains unclear how a shared set of transcription factors generate distinct transcriptional programs across macrophage lineages. In this issue of Immunity, Chen et al. discove...