Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells [0.03%]
糖基化驱动的程序协调髓系衍生抑制细胞的免疫调节和促血管生成功能
Ada G Blidner,Camila A Bach,Pablo A García et al.
Ada G Blidner et al.
Myeloid-derived suppressor cells (MDSCs) promote tumor progression by suppressing antitumor immunity and inducing angiogenesis; however, the mechanisms linking these processes remain uncertain. Here, we identified a glycosylation-dependent ...
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock [0.03%]
ATP结合盒蛋白ABCF1作为E2泛素连接酶调控巨噬细胞极化以抑制致死性脓毒症休克的功能研究
Hitesh Arora,Sara Morgan Wilcox,Laura Alexandra Johnson et al.
Hitesh Arora et al.
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease [0.03%]
小胶质细胞TMEM119通过结合淀粉样蛋白-β促进其清除：阿尔茨海默病小鼠模型中的研究发现
Jing Liu,Zhimeng Wang,Wenwen Liang et al.
Jing Liu et al.
The progression of Alzheimer's disease (AD) involves temporal dynamics of microglial activation. Restoring or maintaining microglial homeostasis has emerged as a promising therapeutic strategy to combat AD. Transmembrane protein 119 (TMEM11...
Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection [0.03%]
克罗恩病风险基因ATG16L1杂合子通过促进独特的蛋白质相互作用来抵抗细菌感染
Xiaomin Yao,Eugene Rudensky,Patricia K Martin et al.
Xiaomin Yao et al.
The T300A substitution in ATG16L1 associated with Crohn's disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here, we demonstrate that heterozygosity for the analogous substitution in mice (Atg16L1T316A), b...
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses [0.03%]
预先存在的表观遗传状态和不同的NF-κB活化塑造2型免疫细胞反应
Vincent Guichard,Felipe Batista Leão,Jingyao Zhao et al.
Vincent Guichard et al.
CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) drive type 2 immune responses via similar effector molecules that are primarily induced by different signals-interleukin (IL)-33 in ILC2s and TCR engagement in Th2 cells....
Longling Silvia Shui,Peter M K Westcott
Longling Silvia Shui
Pancreatic cancer has traditionally been considered refractory to immunotherapy. In a follow-up to the first clinical trial of personalized mRNA vaccines against this deadly cancer, published in Nature, Sethna et al. report compelling evide...
You know my NAMs [0.03%]
你知道我的NAM们
Sourav Ghosh,Carla V Rothlin
Sourav Ghosh
The critical immunoregulatory function of the lung nerve- and airway-associated macrophages (NAMs) is increasingly becoming evident. In this issue of Immunity, Yeung et al. report that NAMs' response to type I interferon limits SARS-CoV-2 s...
nACh receptors engage a nice ChAT with the liver: B cells serving up regeneration [0.03%]
肝细胞再生：nACh受体与胆管细胞协作释放炎症刹车效应
Christoph Schultheiß,Mascha Binder
Christoph Schultheiß
Liver regeneration is a remarkable and unique biological process, orchestrated by an intricate cellular crosstalk of (non-)parenchymal, immune, and nerve cells. In this issue of Immunity, Modares et al. uncover the pivotal role of choline a...
Qixiang Zhao,Changtao Jiang
Qixiang Zhao
Long-term consumption of diets high in fats has detrimental impacts on the immune system, but the window necessary for initiating these effects is unclear. In this issue of Immunity, Xiong et al.1 demonstrate that even short-term exposure t...
Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity [0.03%]
镰状细胞病通过诱导CD8+T细胞染色质内卷和铁死亡来抑制抗肿瘤免疫反应
Zilong Zhao,Benxia Hu,Yalan Deng et al.
Zilong Zhao et al.
Understanding how genetic disorders affect CD8+ T cells in the tumor microenvironment is key to improving cancer immunotherapy. Individuals with sickle cell disease (SCD), the most prevalent inherited blood disorder, have a higher risk of d...