A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses [0.03%]
从GABA能神经元到ADRB2+间质巨噬细胞的脑肺信号促进肺部炎症反应
Weijue Li,Haoyang Zhu,Xiaoyu Zou et al.
Weijue Li et al.
Severe pneumonia is predominantly caused by cytokine storms in the lung, but whether this process is controlled by the brain-lung axis remains unclear. Here, we found that GABAergic neurons in the central amygdala (CeA) were highly activate...
Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy [0.03%]
肝瘤中N1-乙酰亚精胺的外排促进巨噬细胞介导的免疫抑制并降低免疫治疗疗效
Zheng-Yu Liu,Cai-Yuan Wu,Rui-Qi Wu et al.
Zheng-Yu Liu et al.
Metabolic reprogramming is a hallmark of tumor progression. Here, we examined the metabolic profile of hepatocellular carcinoma (HCC), a disease that responds poorly to immune checkpoint blockade (ICB). Polyamine metabolism increased in HCC...
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction [0.03%]
一个CD4+T细胞固有补体C5a受体2-前列腺素I2-白细胞介素1受体2轴调控Th1效应记忆淋巴ocyte的形成和维持机制的研究
Jubayer Rahman,Jack A Bibby,Parul Singh et al.
Jubayer Rahman et al.
T helper 1 (Th1) cell initiation pathways are well characterized; however, those regulating their contraction are less understood. Here, we define a CD4+ T cell-autonomous pathway in which complement C5 orchestrated a shift from prostagland...
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction [0.03%]
抗体Fab和Fc区的特征促进限制结核分枝杆菌
Patricia S Grace,Joshua M Peters,Jaimie Sixsmith et al.
Patricia S Grace et al.
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), a leading cause of death by an infectious disease globally, has no efficacious vaccine. Antibodies are implicated in M. tuberculosis control, but the mechanisms of action...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis [0.03%]
伤害感受神经元通过抑制肺泡巨噬细胞诱导的Siglec-F+中性粒细胞介导的炎症来抵御肺纤维化
Carlos H Hiroki,Mortaza F Hassanabad,Manon Defaye et al.
Carlos H Hiroki et al.
Pulmonary fibrosis results from persistent and pathological tissue repair, which is therapeutically challenging to attenuate and often fatal. The immune processes involved in fibrosis remain ill defined. Using a bleomycin-induced lung fibro...
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies [0.03%]
调节性T细胞的清除促进髓系细胞活化及胶质母细胞瘤抗PD-1和肿瘤靶向抗体治疗的疗效
Felipe Galvez-Cancino,Mariela Navarrete,Gordon Beattie et al.
Felipe Galvez-Cancino et al.
Published Erratum
Immunity. 2025 May 29:S1074-7613(25)00240-7. DOI:10.1016/j.immuni.2025.05.019 2025
Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis [0.03%]
STING1的核定位与其经典信号通路相互竞争以激活AHR来维持共生菌和肠稳态
Ruoxi Zhang,Chunhua Yu,Herbert J Zeh et al.
Ruoxi Zhang et al.
Published Erratum
Immunity. 2025 May 28:S1074-7613(25)00243-2. DOI:10.1016/j.immuni.2025.05.022 2025
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment [0.03%]
增强子驱动的基因调控网络揭示了T细胞在肿瘤微环境中适应和分化过程中的转录因子
William D Green,Amber Gomez,Alec L Plotkin et al.
William D Green et al.
Tumor-infiltrating lymphocytes (TILs) with a tissue-resident memory CD8+ T cell (Trm) phenotype are associated with improved patient outcomes in solid malignancies. To define programs governing the formation of Trm-like TIL, we performed pa...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease [0.03%]
淀粉样蛋白-β通过脂肪生成酶DGAT2诱导脂滴介导的小胶质细胞功能障碍在阿尔茨海默病中的作用
Priya Prakash,Palak Manchanda,Evi Paouri et al.
Priya Prakash et al.
Microglial phagocytosis genes have been linked to increased risk for Alzheimer's disease (AD), but the mechanisms translating genetic association to cellular dysfunction remain unknown. Here, we showed that microglia formed lipid droplets (...
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B [0.03%]
母系自然杀伤细胞通过分泌异常的颗粒酶B驱动子代神经免疫疾病发生发展
Qiwu Bian,Yihang Chen,Jinghe Zhang et al.
Qiwu Bian et al.
Prenatal viral infections can lead to neurodevelopmental disorders in offspring. However, how viral-induced maternal perturbations impact fetal brain macrophages remains insufficiently clear. Here, we demonstrated that inflammatory decidual...