Miriam Wöhner,Falk Nimmerjahn
Miriam Wöhner
A key feature of immunoglobulin G (IgG) antibodies is their capacity to deplete target cells, which is broadly referred to as antibody-dependent cellular cytotoxicity (ADCC). The capacity to kill target cells has made cytotoxic antibodies t...
Brian Y Soong,Nader Yatim,Miriam Merad
Brian Y Soong
Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine,...
Jared R Coombs,Sabrina S Burgener,Kate Schroder
Jared R Coombs
Red blood cells (RBCs) undergo pathological cell death in hemolytic diseases. In a recent issue of Cell, Chen et al. reveal a mode of programmed cell death, spectosis, in which complement activation initiates (mini)NLRP3-caspase-8 complexes...
Gillian Dunphy,David Sancho
Gillian Dunphy
The regulation of myeloid cell responses can determine tumor outcomes. In this issue of Immunity, Blidner et al. report that galectin-1 triggers both immunoregulatory and pro-angiogenic circuits in myeloid cells, promoting tumor growth via ...
Evolutionary medicine in action: Sickle hemoglobin fuels tumor progression [0.03%]
行动起来，用进化医学对抗疾病：镰状血红蛋白促进肿瘤发展
Miguel P Soares
Miguel P Soares
Evolutionary medicine integrates principles of evolutionary biology to understand and treat human diseases. As a classical example, positive selection of the sickle hemoglobin mutation, which confers a survival advantage against malaria in ...
Norman Shreeve,Francesco Colucci
Norman Shreeve
Maternal immune activation (MIA) can cause neurodevelopmental disorders, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Bian et al. show that MIA triggers decidual NK cells to secrete granzyme B, which...
A backhanded complement: Prostacyclin turns inflammation off from the inside out [0.03%]
矛盾的赞誉：前列环素从里到外减弱炎症反应
Samuel E J Preston,Russell G Jones
Samuel E J Preston
To limit hyperactive T helper (Th)1-driven pathology, it is crucial that this T cell population contracts upon pathogen clearance. In this issue of Immunity, Rahman et al. define a complement-C5-mediated lipid-class-switch mechanism that re...
Ding Qiu,Shuishen Zhang,Chanyan Huang et al.
Ding Qiu et al.
Dectin-1 (Clec7a), a C-type lectin receptor for β-glucans, is critical in host defense against fungal infections and has been implicated in allergic responses, yet its role in pulmonary fibrosis remains unclear. In this study, we reveal th...
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair [0.03%]
空间受限且发育过程中具有不同性质的肝巨噬细胞对组织修复是必需的
Federico F De Ponti,Anna Bujko,Zhuangzhuang Liu et al.
Federico F De Ponti et al.
Published Erratum
Immunity. 2025 Jun 6:S1074-7613(25)00234-1. DOI:10.1016/j.immuni.2025.05.013 2025
Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy [0.03%]
细菌抗肿瘤免疫疗法的作用机制：益处与危害的区别
Jesse Garcia Castillo,Sebastian Fernandez,Timothy Campbell et al.
Jesse Garcia Castillo et al.
Bacteria engineered to express tumor antigens as cancer vaccines have produced mixed results. Here, we used an attenuated strain of Listeria monocytogenes (ΔactA, Lm) that lacks tumor antigens to examine the immune response to Lm itself in...