DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis [0.03%]
T细胞中的DOCK8促进Th17和Treg细胞的功能以抑制黏膜肥大细胞并限制口腔过敏反应的易感性
Erin Janssen,Mrinmoy Das,Jordan Butts et al.
Erin Janssen et al.
Immunoglobulin E (IgE)-mediated release of mediators from mast cells (MCs) drives food allergy, and intestinal MC load is an important determinant of disease severity. Dedicator of cytokinesis 8 (DOCK8)-deficient patients are highly suscept...
Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8+ T cells [0.03%]
持续但有限的抗原呈递促进“无助”的记忆CD8⁺T细胞可逆缺陷产生
Verena van der Heide,Gabriel Laghlali,Bennett Davenport et al.
Verena van der Heide et al.
Generation of functional memory CD8+ T cells typically requires engagement of CD4+ T cells. In certain acutely resolving infections, however, effector and memory CD8+ T (Tmem) cell formation appears impervious to the lack of CD4+ T cell hel...
Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages [0.03%]
靶向降解转录因子C/EBPβ可恢复巨噬细胞中泛素编辑酶A20的活性并减少肺纤维化
Shan-Shan Liu,Xiao-Xi Lv,Chang Liu et al.
Shan-Shan Liu et al.
Published Erratum
Immunity. 2025 Jun 24:S1074-7613(25)00284-5. DOI:10.1016/j.immuni.2025.06.015 2025
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis [0.03%]
一种由真菌衍生的赋形剂通过重新编程粒细胞生成来增强卡介苗的抗肿瘤功效
Leonardo F Jurado,Andrew W Daman,Ziyi Li et al.
Leonardo F Jurado et al.
In patients with non-muscle invasive bladder cancer, the standard immunotherapy involves intravesical Bacillus Calmette-Guérin (BCG). However, its success requires repeated doses, and ∼50% of patients do not benefit. Using a preclinical o...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway [0.03%]
APOE3基因中的R136S突变通过抑制cGAS-STING-IFN通路赋予抵抗tau病理的韧性
Sarah Naguib,Chloe Lopez-Lee,Eileen Ruth Torres et al.
Sarah Naguib et al.
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high amyloid burden in the carrier. However, the molecular mechanis...
Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets [0.03%]
转录因子T-bet调节淋巴结和肺效应记忆B细胞亚群的维持和分化潜能
Christopher A Risley,Michael D Schultz,S Rameeza Allie et al.
Christopher A Risley et al.
While human and mouse memory B cells (MBCs) can express the transcription factor T-bet, its role in regulating MBC function remains unclear. We characterized multiple transcriptionally distinct clusters of mature, somatically mutated nucleo...
A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response [0.03%]
一个保守的免疫调节异常标志与感染严重程度、感染前的风险因素和治疗反应有关
Ananthakrishnan Ganesan,Andrew R Moore,Hong Zheng et al.
Ananthakrishnan Ganesan et al.
Older age, being male, obesity, smoking, and comorbidities (e.g., diabetes, asthma) are associated with an increased risk for severe infections. We hypothesized that there is a conserved common immune dysregulation across these risk factors...
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo [0.03%]
神经病理性CGRP增强皮肤树突状细胞功能促进自身反应性CD8+t细胞在白癜中的应答反应
Xiuli Yang,Wenxiang Ding,Fangzhou Lou et al.
Xiuli Yang et al.
Vitiligo is an autoimmune disease characterized by depigmented patches of skin. Autoreactive CD8+ T cells kill melanocytes in vitiligo, but the immunopathogenesis remains elusive and ideal drug targets are lacking. Through single-cell and s...
ILC3s sense gut microbiota through STING to initiate immune tolerance [0.03%]
STING感应肠道微生物以启动免疫耐受诱导 ILC3细胞感知肠道菌群通过STING途径以启动免疫耐受
Wenqing Zhou,Jordan Z Zhou,Anees Ahmed et al.
Wenqing Zhou et al.
Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II+ cells at single-cell resolution from the large intestine. Following colonization with the pathobiont Helicobact...
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation [0.03%]
但氏蛋白多聚体结构揭示了针对Vγ9Vδ2 T细胞受体活化的夹钳机制
Mai Zhang,Yiqing Wang,Ningning Cai et al.
Mai Zhang et al.
Vγ9Vδ2 T cells, the major circulating human γδ T cell subset, respond to infections and tumors by recognizing phosphoantigens (pAgs) via transmembrane butyrophilins (BTN3A1, BTN3A2, and BTN2A1). Here, using cryoelectron microscopy, we r...