Artun Bülbül,Julian Hönninger,Veit R Buchholz
Artun Bülbül
Tumor-infiltrating CD8+ T cells with a tissue-resident memory phenotype have been described in both mice and humans. In this issue of Immunity, Green et al. provide a detailed analysis of the transcriptional and epigenetic regulation of the...
Máté Kiss,Mikael J Pittet
Máté Kiss
Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9hiSPP1lo immunost...
José Pedro Loureiro,Gennaro De Libero
José Pedro Loureiro
T cells expressing the T cell receptor (TCR) Vγ9Vδ2 chains recognize butyrophilins (BTNs) in the presence of phosphorylated antigens (pAgs). In this issue of Immunity, Zhang et al. and Zhu et al. illustrate the mechanism of TCR-BTN intera...
The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells [0.03%]
共刺激分子ICOS限制了衰竭PD-1+CD8+T细胞的内存特性及其功能
Etienne Humblin,Isabel Korpas,Nataliya Prokhnevska et al.
Etienne Humblin et al.
During persistent antigen stimulation, CD8+ T cell responses are maintained by progenitor exhausted CD8+ T (Tpex) cells. Tpex cells respond to blockade of the inhibitory receptor programmed cell death-1 (PD-1), and regulation of their diffe...
Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function [0.03%]
兴奋性神经元衍生的白细胞介素34支持皮层发育小胶质细胞功能
Benjamin A Devlin,Dang M Nguyen,Diogo Ribeiro et al.
Benjamin A Devlin et al.
Neuron-microglia interactions dictate the development of neuronal circuits in the brain. However, the factors that regulate these processes across development are largely unknown. Here, we found that interleukin-34 (IL-34), a neuron-derived...
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer [0.03%]
胰腺癌中突变的p53利用增强子来提高免疫抑制性趋化因子表达并损害免疫检查点抑制剂疗法
Dig B Mahat,Heena Kumra,Sarah A Castro et al.
Dig B Mahat et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by activating KRAS mutations and TP53 alterations. TP53 missense mutations lose their wild-type tumor-suppressor function. Here, we studied whether p53 miss...
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity [0.03%]
肿瘤相关巨噬细胞中线粒体复合物IV的重塑增强I型干扰素信号并促进抗肿瘤免疫
Megan L Clark,Kamen P Simeonov,Walter K Mowel et al.
Megan L Clark et al.
Tumor-associated macrophages (TAMs) influence tumor progression and immune checkpoint blockade (ICB) efficacy. Interferon (IFN)-TAMs predict better survival and ICB responses, yet the mechanisms governing IFN-TAMs remain unclear. Here, we i...
More TOR: The expanding role of mTOR in regulating immune responses [0.03%]
扩大的雷帕霉素哺乳动物目标蛋白在调节免疫反应中的作用
Chirag H Patel,Jonathan D Powell
Chirag H Patel
The mammalian/mechanistic target of rapamycin (mTOR) is an evolutionarily conserved multi-node signaling pathway that integrates critical environmental cues to control cellular growth. Decades worth of studies have intricately dissected the...
Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages [0.03%]
光遗传迷走神经刺激通过限制单核细胞衍生的炎性CCRL2+巨噬细胞的生成来缓解心力衰竭
Guoqi Li,Congcong Zhang,Yang Li et al.
Guoqi Li et al.
Parasympathetic neuronal dysfunction is associated with heart failure (HF), yet the underlying mechanism is poorly understood. Here, we report that targeted vagal nerve stimulation (VNS) using optogenetics attenuated cardiac remodeling and ...
Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota [0.03%]
饮食来源的LPS独立于微生物群决定肠道IgA的诱导和谱系特征
Catherine Mooser,Francesca Ronchi,Julien P Limenitakis et al.
Catherine Mooser et al.
A hallmark of the main secreted antibody immunoglobulin A (IgA) is its mutational load that accumulates throughout life. Although this is mainly interpreted in terms of continuing microbial induction, we show that dietary composition during...