Hai Qi,Mark M Davis,Carola Vinuesa et al.
Hai Qi et al.
Understanding fundamental lymphocyte biology and developing innovative strategies to harness lymphocytes to treat human diseases were the themes of the first SMART Symposium in Immunology held in March 2025 in Shenzhen, China. ...
Yu Ping,Jiqi Shan,Yi Zhang
Yu Ping
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity? [0.03%]
脂质磷酸酶1(LPP1)如何调节抗肿瘤CD8+t细胞活性？
Andrew J Morris,Wouter H Moolenaar
Andrew J Morris
Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells [0.03%]
通过β2整合素机械信号解偶联CAR-T细胞的增殖和分化以产生类干细胞CAR-T细胞
Jiadi Lv,Tian Si,Dianheng Wang et al.
Jiadi Lv et al.
Downstream of T cell receptor (TCR) signaling, proliferation and differentiation programs are thought to be linked to maintain T cell homeostasis. This biology, however, also leads to the in vitro generation of suboptimal chimeric antigen r...
Mitochondria reactive oxygen species signaling-dependent immune responses in macrophages and T cells [0.03%]
巨噬细胞和T细胞中线粒体反应性氧种类信号依赖的免疫应答
Samuel E Weinberg,Navdeep S Chandel
Samuel E Weinberg
Mitochondria are key regulators of immune cell function, going beyond their traditional role in ATP and metabolite production to support anabolic processes and act as hubs for intracellular signaling. A key aspect of this signaling function...
Lai Guan Ng,Ivan Ballesteros,Marco A Cassatella et al.
Lai Guan Ng et al.
Neutrophils, previously considered a homogeneous immune cell population, exhibit substantial heterogeneity. Their diverse phenotypic and functional states are shaped by tissue microenvironments and disease-specific signals. However, the lac...
Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [0.03%]
多胺通过调节性T细胞的功能专业化调控适应性抗肿瘤免疫反应
Georg Bündgen,Alexander Ulges,Jan Pietruschka et al.
Georg Bündgen et al.
In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that can also influence tissue...
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells [0.03%]
MLL3突变通过HIF1α依赖的肿瘤内调节性T细胞募集和分化促进乳腺癌进展
Marie Boutet,Kenta Nishitani,Nicole Couturier et al.
Marie Boutet et al.
Loss-of-function mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. To examine the mechanisms whereby MLL3 suppresses tumorigenesis, we developed a mouse mammary-stem-cell-based tumor...
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1 [0.03%]
基因治疗后人外周血中具有天然淋巴细胞特征的中央记忆T细胞迅速扩增——SCID-X1患者的自身对照研究
Anoop Babu Vasandan,Hossam A Abdelsamed,Shannon K Boi et al.
Anoop Babu Vasandan et al.
Virtual memory T cells, possessing features of innate immune cells, represent a developmental continuum between innate and adaptive immunity. Here, we describe the genesis of virtual memory T cells during early human life. A longitudinal an...
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites [0.03%]
人外周血和组织驻留记忆T细胞在不同部位的异步衰老与周转
Nora Lam,J Carlos Angel,Bruce A Buchholz et al.
Nora Lam et al.
Memory T cells are maintained in tissues as circulating effector-memory (TEM) and tissue-resident (TRM) populations for protective immunity, though the role of site and subset in memory persistence remains undefined. Here, we investigated a...