Carolyn A Thomson,Kathy D McCoy
Carolyn A Thomson
The immune system of wildlings-mice with a wild-derived microbiota-has features similar to that in adult humans. In this issue of Immunity, Oh et al. demonstrate the long-term stability of wildling microbiota and immune traits, establishing...
Zhengxu Ren,Chenqi Xu
Zhengxu Ren
In this issue of Immunity, Lv et al. develop a new CAR-T cell culture system that uses integrin mechanical signaling to boost CAR-T proliferation while preserving stemness, pointing out a new direction of CAR-T manufacturing. ...
Paola Brescia,Maria Rescigno
Paola Brescia
The small intestine coordinates nutrient absorption and immune defense, but the epithelial signaling mechanisms bridging these functions are unclear. In this issue of Immunity, Yu et al. reveal a gasdermin-D-driven circuit that links lipid ...
Petter Brodin,Feng Wang,Bo Zhu et al.
Petter Brodin et al.
Clinical and therapeutic innovation relies on our understanding of the human immune system. Here, investigators discuss current and developing methodologies to study human immunity, and the importance of thoughtful experimental design and s...
Sensory neurons shape local macrophage identity via TGF-β signaling [0.03%]
感觉神经元通过TGF-β信号塑造局部巨噬细胞的特性
Julia Kolter,Clarissa-Laura Döring,Samah Sarout et al.
Julia Kolter et al.
Resident macrophages play integral roles in maintaining tissue homeostasis and function. In the skin, prenatally seeded, specialized macrophages patrol sensory nerves and contribute to their regeneration after injury. However, mechanisms un...
Tolerance to non-inherited maternal antigen is sustained by LysM+ CD11c+ maternal microchimeric cells [0.03%]
LysM+CD11c+母体微嵌合细胞通过维持对非同源母系抗原的耐受性而被保留
Yanyan Peng,Giang Pham,Jiahui Sun et al.
Yanyan Peng et al.
Maternal-fetal microchimerism is increasingly linked with both inflammatory disorders and immune tolerance phenotypes. However, finding microchimeric cells in target tissues does not establish causality, which require platforms for manipula...
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease [0.03%]
ZBP1-RIPK1轴介导的Z-核糖核酸先天免疫识别驱动阿尔茨海默病神经炎症
Ziwen Song,Xingxing Xie,Yulu Chen et al.
Ziwen Song et al.
Neuroinflammation drives Alzheimer's disease (AD) pathogenesis. Z-DNA, a non-canonical left-handed DNA structure, activates innate immune signaling through Z-DNA-binding protein 1 (ZBP1). However, the functional significance of ZBP1-mediate...
Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [0.03%]
锚定位点的筛查鉴定出转录因子蓝本，涉及树突状细胞多样性及亚群特异性抗肿瘤免疫能力
Luís Henriques-Oliveira,Abigail R Altman,Ilia Kurochkin et al.
Luís Henriques-Oliveira et al.
Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset diversification remains poorly understood. Here, we employed a sequenti...
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing [0.03%]
核苷酸依赖性构象变化指导与抗原处理相关的转运蛋白肽类物质的出口方向
James Lee,Victor Manon,Jue Chen
James Lee
The transporter associated with antigen processing (TAP) delivers peptide antigens from the cytoplasm into the endoplasmic reticulum (ER) for loading onto major histocompatibility complex class I (MHC-I) molecules. To examine the mechanisms...
Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier [0.03%]
XBP1通过增强粘液屏障抑制坏死性肠炎诱导的结肠炎
Göksu Gökberk Kaya,Robin Schwarzer,Marius Dannappel et al.
Göksu Gökberk Kaya et al.
Endoplasmic reticulum (ER) stress and necroptosis are associated with the pathogenesis of inflammatory bowel disease (IBD); however, the potential crosstalk between these pathways is unclear. Here, we show that intestinal epithelial cell (I...