Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4 [0.03%]
瘤内低氧通过慢性激活整合应激反应转录因子ATF4促进CD8+T细胞功能障碍
Coral Del Mar Alicea Pauneto,Brian P Riesenberg,Evelyn J Gandy et al.
Coral Del Mar Alicea Pauneto et al.
Metabolic stress in the tumor microenvironment (TME) promotes T cell dysfunction and immune checkpoint inhibitor (ICI) resistance. We examined the contribution of activating transcription factor 4 (ATF4), the central node of the integrated ...
Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing [0.03%]
ISWI介导的核小体定位确保髓系细胞谱系稳定性和信号响应性
Sara Polletti,Júlia Melià-Alomà,Francesco Pileri et al.
Sara Polletti et al.
The interplay between chromatin remodelers and pioneer transcription factors (TFs) regulates cis-regulatory element accessibility to maintain cell identity and transcriptional fidelity. We investigated the impact of imitation of switch (ISW...
Stephanie C Eisenbarth,Facundo Batista,Jason Cyster et al.
Stephanie C Eisenbarth et al.
In the twenty years since extrafollicular B cell responses were originally described, much has been learned about B cell biology. With this progress, the term "extrafollicular" has expanded beyond its initial use to describe a variety of B ...
Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration [0.03%]
杆状小胶质细胞与神经元树突相互作用，在TDP-43相关神经退行性疾病期间降低皮层兴奋性
Manling Xie,Yue Liang,Alessandra S Miller et al.
Manling Xie et al.
Microglia, the principal immune cells of the central nervous system, have emerged as important players in sensing and regulating neuronal activity. While microglial activation is a hallmark in neurodegeneration, the specific role of microgl...
Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function [0.03%]
表达整合素CD103的 naive CD8⁺ T 细胞通过细胞因子获得记忆表型和效应功能
Can Li,Davinna L Ligons,Dominic Lanasa et al.
Can Li et al.
Integrin CD103 binds to E-cadherin, a cell adhesion molecule predominantly expressed on epithelial cells, thus mediating the tissue residency of CD103+ T cells in barrier sites. Importantly, circulating naive CD8+ T cells also express large...
A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer [0.03%]
三阴性乳腺癌肿瘤引流淋巴结中的TLR4依赖性成纤维细胞-单核细胞轴促进转移
Greta Mattavelli,Moutaz Helal,Ana Cetkovic et al.
Greta Mattavelli et al.
Tumor-draining lymph nodes (TDLNs) are sites of anti-tumor immune priming as well as metastases. Here, we examined how the cellular networks within TDLNs are reorganized in triple-negative breast cancer (TNBC). We found that the frequencies...
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation [0.03%]
慢性鼻黏膜炎症的多尺度转录组学揭示了鼻息肉形成过程中的免疫上皮动力学和组织重塑现象
Guanrui Liao,Tsuguhisa Nakayama,Bokai Zhu et al.
Guanrui Liao et al.
Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between diver...
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer [0.03%]
氧化应激诱导的端粒不稳定性驱动癌症中的T细胞功能障碍
Dayana B Rivadeneira,Sanjana Thosar,Kevin Quann et al.
Dayana B Rivadeneira et al.
The tumor microenvironment (TME) imposes immunologic and metabolic stresses sufficient to deviate immune cell differentiation into dysfunctional states. Oxidative stress originating in the mitochondria can induce DNA damage, most notably te...
Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells [0.03%]
肠道微生物代谢产物通过调节皮肤Th17细胞驱动银屑病炎症反应
Chenliang Wang,Shangzhi Dai,Shanshan Zhang et al.
Chenliang Wang et al.
The persistence of tissue-specific chronic inflammation results from an interplay of genetic and environmental factors. How these factors coordinate to sustain pathology in chronic conditions like psoriasis is not well resolved. Using a Car...
Guillem Estivill,Anna C Obenauf
Guillem Estivill
In a recent issue of Nature, Adrover et al. report a neutrophil subset that induces pleomorphic tumor necrosis through neutrophil extracellular trap (NET)-mediated vascular occlusion. This process drives epithelial-to-mesenchymal transition...