Cutting the Gordian knot: Untangling gasdermin C from pyroptosis [0.03%]
破解戈耳狄俄斯之结：解开gasdermin C 与细胞焦亡的关系
Zhaoyu Lin,Hai-Bin Ruan
Zhaoyu Lin
Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses. ...
Reply to nurture over nature in fate decisions of antigen-specific CD8+ T cell clones from an endogenous repertoire [0.03%]
天性与后天在抗原特异性CD8⁺T细胞克隆命运决定中的作用——背靠背文章回应
Leena Abdullah,Joshua J Obar,Yina H Huang
Leena Abdullah
Nurture over nature in fate decisions of antigen-specific CD8+ T cell clones from an endogenous repertoire [0.03%]
效应CTL克隆的命运决定受 nurture因素的影响胜过 nature因素的影响
Adrian Straub,Zahra Abedi,Dirk H Busch et al.
Adrian Straub et al.
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity [0.03%]
原位Pfs230-Pfs48/45复合物与六种阻断疟疾传播抗体的冷冻电镜结构揭示了其作用机制
Ezra T Bekkering,Randy Yoo,Sophia Hailemariam et al.
Ezra T Bekkering et al.
The Pfs230:Pfs48/45 complex forms the basis for leading malaria transmission-blocking vaccine candidates, yet little is known about its molecular assembly. Here, we used cryo-electron microscopy to elucidate the structure of the endogenous ...
Obesity, diabetes, and inflammation: Pathophysiology and clinical implications [0.03%]
肥胖、糖尿病和炎症：病理生理学及临床意义
Marc Y Donath,Daniel J Drucker
Marc Y Donath
Obesity and its related disorders, including type 2 diabetes and liver, kidney, and cardiovascular diseases, are now recognized as chronic inflammatory conditions. Here, we review the mechanisms underlying inflammation in these settings and...
Peter Libby,Oliver Soehnlein
Peter Libby
Inflammatory pathways operate at all stages of atherosclerosis. These processes are driven by risk factors and other stimuli that can spark inflammation by eliciting misdirected responses of intrinsic vascular cells and leukocytes, culminat...
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis [0.03%]
NOTCH3通过破坏调节性T细胞在多发性硬化中驱动自身免疫性神经炎症
Mehdi Benamar,Paola Contini,Klaus Schmitz-Abe et al.
Mehdi Benamar et al.
The immune regulatory defects that promote neuroinflammation in multiple sclerosis (MS) remain unclear. We show that a specific regulatory T (Treg) cell subpopulation expressing Notch3 was increased in individuals with MS and in mice with e...
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells [0.03%]
转录抑制因子BLIMP1制约CD8⁺T细胞记忆分化命运
Maegan K Murphy,Matthew McCullen,Joshua L Deffenbaugh et al.
Maegan K Murphy et al.
During differentiation of CD8+ T cells, the transcription factors TCF-1 and Blimp1 control progenitor and terminally differentiated states, respectively. Here, we examined the hierarchy and functional consequences of cross-regulation betwee...
Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes [0.03%]
Eomesodermin+ CD4+ T细胞对治愈性免疫疗法效果至关重要
Ping Zhang,Françoise Haeseleer,Olivia G Waltner et al.
Ping Zhang et al.
Interleukin 10 (IL-10)-producing CD4+ type-1 regulatory T cells (Tr1) promote immune tolerance during chronic infection, autoimmunity, and transplantation. However, specific Eomesodermin (Eomes)-dependent stages of Tr1 differentiation and f...
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis [0.03%]
金黄色葡萄球菌参与皮肤抗原致敏引起的basophil和白细胞介素4依赖性食物过敏反应增强现象
Mrinmoy Das,Mohammed Alasharee,Brian Woods et al.
Mrinmoy Das et al.
The mechanism of the association of S. aureus skin colonization with food allergy in atopic dermatitis (AD) is unknown. Interleukin-4 (IL-4) plays an important role in food allergy. We found elevated serum IL-4 concentrations in AD patients...