Kristine E Zengeler,John R Lukens
Kristine E Zengeler
Individuals with neurodevelopmental disorders often experience comorbid gastrointestinal distress and dysregulated immune responses, yet the underlying mechanisms remain unclear. In this issue of Immunity, Kim et al. utilize a murine matern...
Theresa V Rohm,Daniel T Meier,Jerrold M Olefsky et al.
Theresa V Rohm et al.
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state contributes to long-term complications of diabetes, includin...
Lavanya Sivapalan,Valsamo Anagnostou
Lavanya Sivapalan
Human leukocyte antigen (HLA) molecules are critical mediators of anti-tumor immune responses. In this issue of Immunity,Chhibber et al. (2021) challenge previous associations between germline HLA zygosity and immunotherapy outcomes, demons...
Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait [0.03%]
抗原结合特异性分析揭示抗体表位选择是一项可遗传的性状
Thiagarajan Venkataraman,Cristian Valencia,Massimo Mangino et al.
Thiagarajan Venkataraman et al.
Human immune responses to viral infections are highly variable, but the genetic factors that contribute to this variability are not well characterized. We used VirScan, a high-throughput epitope scanning technology, to analyze pan-viral ant...
Nicole M Chapman,Hongbo Chi
Nicole M Chapman
Adaptive immune responses mediated by T cells and B cells are crucial for protective immunity against pathogens and tumors. Differentiation and function of immune cells require dynamic reprogramming of cellular metabolism. Metabolic inputs,...
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures [0.03%]
TGF-β介导的基因组组织者SATB1的沉默促进Tfh细胞分化和瘤内三级淋巴器官结构形成
Ricardo A Chaurio,Carmen M Anadon,Tara Lee Costich et al.
Ricardo A Chaurio et al.
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation of PD-1 expression by the genomic organizer SATB1...
Jonathan A Cohen,Daniel H Kaplan
Jonathan A Cohen
Peripheral neurons and immune cells interact to modulate inflammation, but whether the brain can control this process is unknown. In a recent issue of Cell, Koren et al. (2021) show that peripheral inflammation is encoded in the insular cor...
Paola de Candia,Giuseppe Matarese
Paola de Candia
The role of folate-dependent one carbon (1C) metabolism in CD4+ T cell polarization is incompletely understood. In this issue of Immunity, Sugiura et al. (2021) provide evidence that blocking the 1C metabolic enzyme MTHFD2 may curb pro-infl...
Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia [0.03%]
活化血小板中转录因子NFAT活性的抑制增强了其聚集并加重了革兰氏阴性细菌败血症的症状
Valentina Poli,Marco Di Gioia,Martha Sola-Visner et al.
Valentina Poli et al.
During gram-negative septicemia, interactions between platelets and neutrophils initiate a detrimental feedback loop that sustains neutrophil extracellular trap (NET) induction, disseminated intravascular coagulation, and inflammation. Unde...
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization [0.03%]
分析HCV精英中和者的抗体鉴定广谱中和的遗传决定因素
Timm Weber,Julian Potthoff,Sven Bizu et al.
Timm Weber et al.
The high genetic diversity of hepatitis C virus (HCV) complicates effective vaccine development. We screened a cohort of 435 HCV-infected individuals and found that 2%-5% demonstrated outstanding HCV-neutralizing activity. From four of thes...