Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation [0.03%]
病毒感染诱发的细胞膜完整性改变通过激活SMPDL3B降解cGAMP限制cGAS-STING信号通路
Zhimeng Wang,Yanfei Hou,Peiyuan Liu et al.
Zhimeng Wang et al.
The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway mediates antiviral innate immunity upon sensing cytosolic DNA. Here, we examined the impact of sphingomyelin ...
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [0.03%]
转录因子NFIL3驱动淋巴样祖细胞向固有淋巴细胞分化Specification
Joseph Léger,Eva Artano,Delphine Coulais et al.
Joseph Léger et al.
Understanding the mechanisms that initiate innate lymphoid cell (ILC) specification may reveal how ILC functions in immunity and tissue homeostasis are programmed. Using an Il7r-lineage tracing mouse strain, we identified developmental inte...
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions [0.03%]
单细胞空间转录组揭示慢性进行性多发性硬化症病灶中的致病性炎症微环境
Ruoqing Feng,Lena Spieth,Lu Liu et al.
Ruoqing Feng et al.
Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A hallmark of this persistent and slowly evolving inflammatory process is chronic active MS...
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures [0.03%]
空间免疫特征分析定义了一种具有功能三级淋巴结构的人类胶质瘤亚型
Pinar Cakmak,Jennifer H Lun,Aakanksha Singh et al.
Pinar Cakmak et al.
Adult-type diffuse gliomas, the most common primary brain tumors, respond poorly to immune-based therapies and are considered immunologically "cold" tumors. Here, we examined the features and clinical relevance of glioma intratumoral tertia...
ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death [0.03%]
ATG9A介导的自噬通过限制TNFR1驱动的STING激活和ZBP1依赖性细胞死亡来预防炎症性皮肤疾病
Dario Priem,Jon Huyghe,Barbara Gilbert et al.
Dario Priem et al.
Tumor necrosis factor (TNF) is a central pro-inflammatory cytokine with pathologic roles in chronic inflammatory and autoimmune disorders. The mechanisms by which TNF sensing drives the pathogenesis of these diseases are not fully understoo...
Primate resident memory T cells activate humoral and stromal immunity [0.03%]
灵长类动物的驻留记忆T细胞激活体液和基质免疫反应
Vineet Joag,Benjamin N Bimber,Clare F Quarnstrom et al.
Vineet Joag et al.
CD8+ resident memory T (Trm) cells comprise a small population of frontline sentinels compared with the large tissues they surveil, making outsized contributions to immune protection from infection. Here, we interrogated mechanisms of Trm c...
Danae N Mitchell,Julie A Siegenthaler
Danae N Mitchell
Fibroblasts and immune cells robustly respond to brain injuries and form a persistent "scar." In a recent issue of Nature, Ewing-Crystal et al. report that fibroblasts have dynamic states that modulate neuroinflammatory responses to brain i...
Alzheimer's alphabet soup: Find the letters "Z-DNA-ZBP1-RIPK1" [0.03%]
阿尔茨海默病的字母汤：找到“Z-DNA-ZBP1-RIPK1”中的字母
Jake A Gertie,Hachung Chung
Jake A Gertie
Neuroinflammation contributes to Alzheimer's disease (AD), but the molecules and pathways that initiate inflammation are unclear. In this issue of Immunity, Song et al. demonstrate that ZBP1-RIPK1 signaling in microglia can drive AD, wherei...
Sigrun Stulz,Georg Gasteiger
Sigrun Stulz
Vaccines that induce immunity in tissues are urgently needed. In this issue of Immunity, Joag et al. demonstrate that systemic vaccination of primates induces tissue-resident CD8+ T cells in numerous organs that can activate antiviral respo...
Burning the candle at both ends: ROS-mediated telomere damage drives T cell dysfunction [0.03%]
两端同时燃烧：ROS介导的染色体端粒损伤驱动T细胞功能障碍
Alexander J Wesolowski,Rahul Roychoudhuri
Alexander J Wesolowski
T cells need reactive oxygen species (ROS) for activation and memory formation, yet excessive ROS can drive dysfunction. Rivadeneira et al. show that chronic T cell activation in tumors exposes telomeres to damaging mitochondrial ROS, contr...