An allele of a hexameric enzyme is poised for an autoimmune dangerous mix [0.03%]
一个六聚体酶的等位基因准备好了与自身免疫危险因素结合
Di Wu,Benjamin D Sheppard,Adam D Steinbrenner
Di Wu
In this issue of Molecular Cell, Wan et al.1 elucidate how incompatible genetic interactions between immune receptors and cellular homeostatic enzymes can lead to hybrid necrosis in the plant Arabidopsis thaliana. This suggests that the imm...
Tatsuaki Kurosaki,Hana Cho,Elizabeth T Abshire et al.
Tatsuaki Kurosaki et al.
Fragile X syndrome (FXS) results from a deficiency of the ubiquitously expressed RNA-binding protein fragile X protein (FMRP). While FMRP-mediated translational repression has been attributed primarily to ribosome stalling, using immunoprec...
Martin Gamerdinger,Blanca Echeverria,Alfred M Lentzsch et al.
Martin Gamerdinger et al.
N-myristoyltransferases (NMTs) cotranslationally transfer the fatty acid myristic acid to the N terminus of newly synthesized proteins, regulating their function and cellular localization. These enzymes are important drug targets for the tr...
TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling [0.03%]
TRIM24通过染色质信号传导指导复制压力反应以维持ALT端粒体
Daein Kim,Ragini Bhargava,Shih-Chun Wang et al.
Daein Kim et al.
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop biotinylation of lac operator (LacO) array replication stress protein network identification (BLOCK-ID) in human cancer cells, a prot...
Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance [0.03%]
染色体栓系和有丝分裂转录促进ecDNA核继承
Ashley Nichols,Yujin Choi,Roshan Xavier Norman et al.
Ashley Nichols et al.
Extrachromosomal DNAs (ecDNAs) are circular DNAs that function in tumor progression and treatment resistance by amplifying oncogenes. ecDNAs lack centromeres and thus are not constrained to Mendelian segregation, enabling unequal and rapid ...
Alessandro Borsellini,Duccio Conti,Erin E Cutts et al.
Alessandro Borsellini et al.
Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this process in early mitosis, what triggers its activation and loading onto chromatin at this junc...
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function [0.03%]
调亡平衡染色质凝集物与可溶性复合物在转录因子功能中的作用模型
Anne Bremer,Walter H Lang,Ryan P Kempen et al.
Anne Bremer et al.
Phase separation regulates many biological processes, but the role of transcription factor (TF)-mediated condensates in gene regulation is contentious. We used Gcn4, a prototypical budding yeast TF, to assess two competing models for transc...
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction [0.03%]
MLKL通过诱导坏死性凋亡释放线粒体DNA激活cGAS-STING信号通路
Zhangcheng Ding,Rui Wang,Yuhua Li et al.
Zhangcheng Ding et al.
Necroptosis is a pro-inflammatory, lytic cell death executed by a pseudokinase mixed lineage kinase-like protein MLKL. Upon necroptosis induction by various inflammatory signals, MLKL is phosphorylated by receptor-interacting serine/threoni...
Johannes A Kuehn,Rafael Pinilla-Redondo
Johannes A Kuehn
In a recent paper in Nature, Tan et al.1 describe the bacterial Hailong anti-phage system, in which constitutively synthesized DNA oligonucleotides inhibit a toxic ion channel-a molecular booby trap primed for activation by phage exonucleas...
Thomas D Jackson,Jonathan M Palozzi,Pere Puigserver
Thomas D Jackson
In this issue of Molecular Cell, Chen et al.1 identify a novel arginine-sensing system, composed of the cytosolic proteins BAG2 and SAMD4B, which promotes cancer cell survival during arginine deficiency. ...