Mingchuang Sun,Li Zhuang,Boyi Gan
Mingchuang Sun
In this issue of Molecular Cell, Minikes et al.1 reveal that hypoxia suppresses ferroptosis independently of HIF signaling via inhibition of the oxygen-sensitive histone demethylase KDM6A, linking hypoxia-mediated chromatin regulation to ph...
Tethered to survive: Mitotic transcription secures faithful inheritance of extrachromosomal DNA [0.03%]
依赖生存：有丝分裂转录保证了细胞外染色体DNA的忠实继承
Xue Jin,Roel G W Verhaak
Xue Jin
In this issue of Molecular Cell, Nichols et al.1 uncover a transcription-dependent tethering mechanism that enables mitotic inheritance of extrachromosomal DNA (ecDNA) in cancer cells, revealing how transcriptionally active ecDNA escapes de...
Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex [0.03%]
由YY1-Lig3-PARylation复合物介导的染色体外DNA生成依赖于DNA环出和连接反应
Lu-Ning Qin,Ting Wu,Xue-Ting Zhen et al.
Lu-Ning Qin et al.
The link between extrachromosomal DNA (ecDNA) and tumors has been well established, and its role in cancer is of increasing interest. While ecDNA is thought to originate from genomic instability, the molecular mechanisms driving DNA end lig...
PALB2 and 53BP1 govern post-resection homologous recombination DNA repair [0.03%]
PALB2和53BP1调控重组修复中的解旋环节
Yifan Wang,Yan Coulombe,Wei-Ting Yueh et al.
Yifan Wang et al.
Homologous recombination (HR) requires the resection of DNA breaks and RAD51 filament formation. Protein complexes that control end resection have been characterized, but regulators of RAD51 loading are not well defined. PALB2 is a mediator...
Deyasini Chakraborty,Colby R Sandate,Luke Isbel et al.
Deyasini Chakraborty et al.
Pioneer transcription factors (TFs) engage chromatinized DNA motifs. However, it is unclear how the resultant TF-nucleosome complexes are decoded by co-factors. In humans, the TF p53 regulates cell-cycle progression, apoptosis, and the DNA ...
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA [0.03%]
利用快速的PRO-seq对新生RNA进行剖析以增强转录组测序映射
Pradeep Kumar Reddy Cingaram,Felipe Beckedorff,Jingyin Yue et al.
Pradeep Kumar Reddy Cingaram et al.
Precision nuclear run-on (PRO) sequencing (PRO-seq) is a powerful technique for mapping transcriptomes with nucleotide resolution and measuring newly synthesized transcripts at both promoters and enhancer elements. The current PRO-seq proto...
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria [0.03%]
人类线粒体启动子识别、转录因子结合和释放的结构基础
Karl Herbine,Ashok R Nayak,Angelica Zamudio-Ochoa et al.
Karl Herbine et al.
Transcription in human mitochondria is driven by a core apparatus consisting of a Pol A family RNA polymerase (mtRNAP), the initiation factors TFAM and TFB2M, and the elongation factor TEFM. While earlier structures of initiation and elonga...
Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism [0.03%]
人类线粒体RNA聚合酶结构揭示了转录起始位点和滑动机制
Jiayu Shen,Quinten Goovaerts,Yogeeshwar Ajjugal et al.
Jiayu Shen et al.
Transcription of the human mitochondrial DNA is initiated by POLRMT and initiation factors mitochondrial transcription factor A (TFAM) and mitochondrial transcription factor B2 (TFB2M). We present cryo-electron microscopy (cryo-EM) structur...
Alexander M Minikes,Pei Liu,Hua Wang et al.
Alexander M Minikes et al.
Ferroptosis, a metabolic cell death process driven by iron-dependent phospholipid peroxidation, is implicated in various pathologies, including cancer. While metabolic factors such as glucose, lipids, and multiple amino acids have all been ...
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function [0.03%]
AMPK介导的EZH2磷酸化对PRC2甲基转移酶活性和致癌功能的抑制作用
Lixin Wan,Kexin Xu,Yongkun Wei et al.
Lixin Wan et al.
Published Erratum
Molecular cell. 2025 Jul 23:S1097-2765(25)00612-4. DOI:10.1016/j.molcel.2025.07.011 2025