Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 [0.03%]
染色质凝聚物质Nup98离散体可调动异染色质DSBs并排斥Rad51蛋白
Chiara Merigliano,Taehyun Ryu,Jakub Cibulka et al.
Chiara Merigliano et al.
Published Erratum
Molecular cell. 2025 Aug 14:S1097-2765(25)00662-8. DOI:10.1016/j.molcel.2025.08.012 2025
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress [0.03%]
组蛋白变体mH2A1.2的泛素化可防止在复制压力下特定基因组位点RAD18过量累积导致细胞中毒现象发生
Maxime Galloy,Andréanne Blondeau,Élodie Vion et al.
Maxime Galloy et al.
Spatiotemporal recruitment of DNA repair factors is crucial to coordinate repair across DNA lesions. MacroH2A1.2 (mH2A1.2), which accumulates in subgenomic regions that are difficult to replicate (e.g., common fragile sites, telomeres, and ...
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function [0.03%]
AMPK介导的EZH2磷酸化抑制PRC2甲基转移酶活性及致癌功能
Lixin Wan,Kexin Xu,Yongkun Wei et al.
Lixin Wan et al.
Published Erratum
Molecular cell. 2025 Aug 13:S1097-2765(25)00661-6. DOI:10.1016/j.molcel.2025.08.011 2025
Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex [0.03%]
单链DNA结合蛋白是结构蛋白LDB1复合物的组成成分
Xiaokang Wang,Nicholas G Aboreden,Ying Cai et al.
Xiaokang Wang et al.
Transcriptional enhancers are brought into proximity with promoters via chromatin looping. The architectural transcription cofactor LDB1 facilitates spatial connectivity among enhancers and promoters, but whether this occurs through simple ...
Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate [0.03%]
通过靶向后突触密度凝聚物的网络节点来调节突触谷氨酸受体
Bowen Jia,Shihan Zhu,Zeyu Shen et al.
Bowen Jia et al.
Biological condensates are assembled through phase separation and play critical roles in diverse cellular processes. Condensates in cells form percolated molecular networks via multi-valent interactions among biomolecules. How the network p...
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation [0.03%]
人类干细胞和心脏分化过程中PRC2亚复合物的特异性和功能不同
Christian Much,Sandy M Rajkumar,Liming Chen et al.
Christian Much et al.
The dynamic regulation of epigenetic states relies on complex macromolecular interactions. PRC2, the methyltransferase complex depositing H3K27me3, interacts with distinct accessory proteins to form the mutually exclusive subcomplexes PHF1-...
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development [0.03%]
整合子促进TFIID和RNA聚合酶II的关联以在发育过程中维持多能性
Raghu Ram Edupuganti,Felipe Beckedorff,Pradeep Kumar Reddy Cingaram et al.
Raghu Ram Edupuganti et al.
The mechanisms by which the expression of pluripotency and Polycomb networks are harmonized to allow the transition from pluripotency to a differentiated state have not been fully elucidated. Integrator complex regulates transcription pause...
Sevi Durdu,Murat Iskar,Luke Isbel et al.
Sevi Durdu et al.
Transcription factors (TFs) recognizing DNA motifs within regulatory regions drive cell identity. Despite recent advances, their specificity remains incompletely understood. Here, we address this by contrasting two TFs, Neurogenin-2 (NGN2) ...
Killing liquid condensates with a micropeptide toward modulating condensatopathies [0.03%]
一种微肽通过靶向液滴凝聚物来治疗凝集病的新策略
Leshan Yang,Yifan Dai
Leshan Yang
In a recent Nature article, Zhang et al.1 develop a non-natural micropeptide killswitch that modulates the material properties and biomolecular composition of target condensates, enabling direct regulation of cellular processes in condensat...
Erika Valeri,Moritz M Gaidt
Erika Valeri
The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In a recent Cell publication, Lahaye et al.1 discovered that viral infection triggers de novo synthesis of self-DNA-activating cGAS. ...