KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 [0.03%]
KIDINS220和InsP8保障磷酸盐出口调节酶XPR1的逐步调控
Xiaojie Wang,Zhongjian Bai,Ciara Wallis et al.
Xiaojie Wang et al.
XPR1 is emerging as the only known inorganic phosphate (Pi) exporter in humans, critical for Pi homeostasis, with its activity stimulated by inositol pyrophosphate InsP8 and regulated by neuronal scaffold protein KIDINS220. Our structural s...
Endocytosis is essential for cysteine-deprivation-induced ferroptosis [0.03%]
内吞作用对半胱氨酸剥夺诱导的铁死亡是必不可少的
Xuesong Liu,Zechuan Zhao,Zhixuan Bian et al.
Xuesong Liu et al.
Ferroptosis is a form of cell death caused by iron-dependent phospholipid peroxidation and subsequent membrane rupture. Autophagic degradation of the iron-storage protein ferritin promotes ferroptosis by increasing cytosolic bioactive iron,...
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation [0.03%]
扩增可成药的锌指蛋白组以定义药物诱导降解的属性
Mikołaj Słabicki,Jiho Park,Radosław P Nowak et al.
Mikołaj Słabicki et al.
Glutarimide analogs, such as thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce degradation of certain zinc finger (ZF) proteins. Although the core structural motif recognized by CRBN has been characterized, it does not fully ...
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense [0.03%]
一种广泛的病毒海绵蛋白家族揭示了抗噬菌体防御中对核苷酸信号的特异性抑制作用
Renee B Chang,Hunter C Toyoda,Samuel J Hobbs et al.
Renee B Chang et al.
Cyclic oligonucleotide-based anti-phage signaling systems (CBASSs) are bacterial anti-phage defense operons that use nucleotide signals to control immune activation. Here, we biochemically screen 57 diverse E. coli and Bacillus phages for t...
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition [0.03%]
HIV-1核输出复合物揭示了RNA在CRM1货物识别中的作用
Amber M Smith,Yang Li,Arianna Velarde et al.
Amber M Smith et al.
HIV utilizes host proteins to manipulate cellular processes during replication. One key interaction involves the HIV regulatory protein Rev with the highly conserved nuclear exportin chromosome region maintenance 1(CRM1), which exports >1,0...
Ivan Dikic,Cristina Mayor-Ruiz,Georg E Winter et al.
Ivan Dikic et al.
In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating ...
Jin Gao,Yan Wang,Quan Chen
Jin Gao
A recent study in Nature reports a mechanism for cancer cells to defend against ferroptosis. Calhoon et al.1 showed that glycosaminoglycans on the cell surface promote lipoprotein uptake in cancer cells and deliver anti-ferroptotic metaboli...
The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens [0.03%]
双管齐下：在体内池遗传筛选中结合影像组学和测序作为读出方式的力量
Carlos Jiménez,Nicola Crosetto,Magda Bienko
Carlos Jiménez
In a recent publication in Cell, Saunders et al.1 describe an important step forward for in vivo genetic screens, by enabling parallel tissue imaging and sequencing, boosting the discovery of gene-phenotype links that had previously gone un...
Sticky business: Rationalizing CRBN's zinc-finger targeting by molecular glues [0.03%]
黏而不忘：分子胶通过理性设计结合CRBN的锌指结构域
Jonathan W Bushman,Patrick Ryan Potts
Jonathan W Bushman
In this issue of Molecular Cell, Słabicki et al.1 report a comprehensive survey of human zinc-finger proteins susceptible to degradation by CRBN-targeting molecular glues, both refining and expanding on the established rules for targeting ...
PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance [0.03%]
PRDX6参与硒半胱氨酸代谢和铁死亡抵抗
Zhiyi Chen,Alex Inague,Kamini Kaushal et al.
Zhiyi Chen et al.
Published Erratum
Molecular cell. 2025 Aug 14:S1097-2765(25)00655-0. DOI:10.1016/j.molcel.2025.08.005 2025