Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response [0.03%]
内源性YAP/TAZ在TEAD凝聚物中的分区协调Hippo反应
Tianxin Zhu,Huan Li,Siwei Mao et al.
Tianxin Zhu et al.
YAP/TAZ are transcriptional co-activators that pair with transcription factor TEA/ATTS domains (TEADs) for modulating the Hippo pathway. Previous works propose the potential role of YAP/TAZ phase separation for transcriptional activation, y...
Target RNA recognition drives PIWI∗ complex assembly for transposon silencing [0.03%]
靶RNA识别驱动PIWI*复合体组装以沉默转座子
Júlia Portell-Montserrat,Laszlo Tirian,Changwei Yu et al.
Júlia Portell-Montserrat et al.
PIWI-clade Argonaute proteins and their associated PIWI-interacting RNAs (piRNAs) are essential guardians of genome integrity, silencing transposable elements through distinct nuclear and cytoplasmic pathways. Nuclear PIWI proteins direct h...
A conserved PIWI silencing complex detects piRNA-target engagement [0.03%]
一个保守的PIWI沉默复合体检测piRNA靶点结合事件
Dipayan De,Sucharita Sarkar,Luca F R Gebert et al.
Dipayan De et al.
In animal germ cells, PIWI proteins use piRNAs to detect active selfish genetic elements. Base-pairing to a piRNA defines transposon recognition, but how this interaction triggers a defensive response remains unclear. Here, we identify a tr...
Alexander P Young,Thirumala-Devi Kanneganti
Alexander P Young
TLRs detect pathogen-derived uridine but not endogenous pseudouridine, which promotes host defense without autoimmunity. This principle is critical for the safe design of mRNA-based therapeutics, but the underlying mechanisms driving differ...
Julia Barczuk,Dragomir Milovanovic
Julia Barczuk
How does synaptic wiring depend on receptor clustering, scaffold networks, and signaling cohorts? In a recent study in Molecular Cell, Jia et al.1 demonstrate that targeting the interaction strength between the scaffold proteins, rather tha...
A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response [0.03%]
一种氨基酸感应调节因子连接脂质过氧化与脂滴依赖性抗氧化响应
Jinhua Li,Yansong Zhang,Jingyu Peng et al.
Jinhua Li et al.
Recent studies highlight the antioxidant role of lipid droplets (LDs) in shielding unsaturated lipids from peroxidation. While LDs accumulate during oxidative stress, the underlying mechanism remains unclear. Our previous research revealed ...
A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation [0.03%]
一种CDK11依赖的RNA聚合酶II暂停-检查点先于CDK9介导的转录延长转换
Jennifer R Devlin,Ben Martin,Nenad Bartonicek et al.
Jennifer R Devlin et al.
Controlled gene expression is achieved through the intricate regulation of RNA polymerase II (Pol II) progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requ...
SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation [0.03%]
SKP1A通过结合多梳沉默基因介导PRC2降解并预设其激活状态
Takashi Kondo,Shinsuke Ito,Junichiro Takano et al.
Takashi Kondo et al.
Polycomb group (PcG) proteins are repressors of developmental genes. Paradoxically, the same PcG proteins also function in gene activation via mechanisms that are not yet fully understood. Here, we found that SKP1A, an essential factor of S...
VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing [0.03%]
VEL依赖性聚合维系多梳蛋白染色质结合以启动表观基因沉默机制
Anna Schulten,Geng-Jen Jang,Alex Payne-Dwyer et al.
Anna Schulten et al.
Multivalent protein-chromatin interactions facilitated by higher-order protein assemblies are emerging as a crucial theme in eukaryotic gene regulation. However, understanding the underlying mechanisms in their functional context remains ch...
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision [0.03%]
G2期间的p21-CDK反馈中的氧化还原开关控制增殖和细胞周期退出决策
Julia Vorhauser,Theodoros I Roumeliotis,David Coupe et al.
Julia Vorhauser et al.
Reactive oxygen species (ROS) influence cell proliferation and fate decisions by oxidizing cysteine residues (S-sulfenylation) of proteins, but specific targets and underlying regulatory mechanisms remain poorly defined. Here, we employ red...