A fork in the road: PADI4 citrullinates p53 to control immune-related networks [0.03%]
岔路口：PADI4 对 p53 的瓜氨酸化调控免疫相关网络
Sayan Bhattacharjee,Kausik Regunath,Carol Prives
Sayan Bhattacharjee
How does the p53 tumor suppressor choose which transcriptional targets to regulate? In this issue, Indeglia et al.1 reveal that PADI4 citrullinates p53, redirecting its binding to ETS sites, enhancing immune-related gene expression, and pro...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity [0.03%]
利什曼原虫致病因子利用变构激酶开关调控其泛素连接酶活性
Thornton J Fokkens,Elisa T Rauh,Madita Wolter et al.
Thornton J Fokkens et al.
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating protein kinase and ubiquitin ligase domains within a single protein. This module is widesprea...
Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity [0.03%]
C端延伸的泛素前体蛋白促进蛋白质稳态和延长寿命
Selver Altin,Tânia Simões,Christina Behrendt et al.
Selver Altin et al.
Ubiquitin is a conserved modifier regulating the stability and function of numerous target proteins. In all eukaryotes, polyubiquitin precursors are generated and processed into ubiquitin monomers. The final ubiquitin unit always contains a...
The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity [0.03%]
核孔复合体连接能量感应与长寿中的转录可塑性
Yifei Zhou,Fasih M Ahsan,Sinclair W Emans et al.
Yifei Zhou et al.
As the only gateway governing nucleocytoplasmic transport, the nuclear pore complex (NPC) maintains fundamental cellular processes and deteriorates with age. However, the study of age-related roles of single NPC components remains challengi...
Rapid remodeling of NTP levels enables immediate translational adaptation to energy stress in yeast [0.03%]
酵母中能量压力下的快速tRNA充能机制及其在蛋白质翻译中的作用
Katherine Bexley,Michaela Ristová,Sushma Sharma et al.
Katherine Bexley et al.
In Saccharomyces cerevisiae, glucose depletion induces metabolic reprogramming through widespread transcriptional and translational reorganization. We report that initial, very rapid translational silencing is driven by a specialized metabo...
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations [0.03%]
MATR3形成球形和线性聚合物，这种作用可受到RNA结合及ALS/FTD相关突变的调节
Macy L Sprunger,Min Kyung Shinn,Sabrina K Talir et al.
Macy L Sprunger et al.
Matrin-3 (MATR3) is an RNA-binding protein (RBP) that is associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). MATR3 features two RNA recognition motifs, two zinc-finger motifs, and four intrinsical...
mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport [0.03%]
雷帕霉素靶蛋白抑制通过诱导脂质摄取的替代途径并促进胆固醇运输来重编程细胞脂质稳态
Sejeong Shin,Min-Joon Han,Ishika Patel et al.
Sejeong Shin et al.
The mechanistic target of rapamycin (mTOR) is a key regulator of lipid homeostasis by controlling processes including lipid uptake and biosynthesis. mTOR dysregulation and consequent altered lipid metabolism are common in various diseases, ...
Structural characterization of five functional states of metabotropic glutamate receptor 8 [0.03%]
代谢型谷氨酸受体8的五个功能状态的结构特征
Jie Zhao,Yue Deng,Zheng Xu et al.
Jie Zhao et al.
Metabotropic glutamate receptors (mGluRs) are dimeric class C G protein-coupled receptors, which play crucial roles in brain physiology and pathology. Among them, mGlu8 is the least characterized, though it is physiologically important. Whi...
RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity [0.03%]
两栖动物到爬行动物的进化中RAD23B获得铜金属载荷适配体功能以增加代谢和调控基因组完整性
Tong Xiao,Dan He,Danqian Liu et al.
Tong Xiao et al.
Increasing brain complexity is a major step in the evolution of species. Here, we show that, in the transition from amphibians to reptiles, the DNA repair protein RAD23B acquires a metalloadaptor function that allows it to serve as a centra...
The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain [0.03%]
组蛋白伴侣Spt6通过其保守的N端结构域调控染色质的结构
James L Warner,Vanda Lux,Václav Veverka et al.
James L Warner et al.
The disassembly and reassembly of nucleosomes by histone chaperones is an essential activity during eukaryotic transcription elongation. This highly conserved process maintains chromatin integrity by transiently removing nucleosomes as barr...