PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1 [0.03%]
PRC2.1和PRC2.2特异性辅助蛋白招募不同的经典PRC1形式
Eleanor Glancy,Cheng Wang,Ellen Tuck et al.
Eleanor Glancy et al.
Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to promote stable repression of developmental genes. PRC2 forms two major subcomp...
Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease [0.03%]
人tRNA剪接内切酶切除预tRNA内含子的结构基础
Xiaofeng Zhang,Fenghua Yang,Xiechao Zhan et al.
Xiaofeng Zhang et al.
Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of life. In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) comprising four subunits: TSEN2, TSEN15, TSEN34, and TSEN54. Here,...
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens [0.03%]
通过单细胞干扰筛选揭示mSWI/SNF染色质重塑复合物的结构和功能属性
Jordan E Otto,Oana Ursu,Alexander P Wu et al.
Jordan E Otto et al.
The mammalian SWI/SNF (mSWI/SNF or BAF) family of chromatin remodeling complexes play critical roles in regulating DNA accessibility and gene expression. The three final-form subcomplexes-cBAF, PBAF, and ncBAF-are distinct in biochemical co...
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA [0.03%]
压力颗粒是防止双链RNA诱导的先天免疫反应过度活化的缓冲器
Max Paget,Cristhian Cadena,Sadeem Ahmad et al.
Max Paget et al.
Proper defense against microbial infection depends on the controlled activation of the immune system. This is particularly important for the RIG-I-like receptors (RLRs), which recognize viral dsRNA and initiate antiviral innate immune respo...
Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis [0.03%]
线粒体介导的端粒依赖性抑癌机制在复制型危机时被激活
Venus Marie Gaela,Liuh-Yow Chen
Venus Marie Gaela
Nassour et al.1 report that telomere dysfunction communicates with mitochondria via the ZBP1-TERRA-MAVS axis. This pathway activates a detrimental innate immune response that may promote the elimination of cells prone to oncogenic transform...
Zhiming Li,Zhiguo Zhang
Zhiming Li
Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro ...
Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation [0.03%]
ALKBH5-m6A-SF3B1在白血病转化中的交替去甲基编辑与修复调控机制
Zhongyu Zou,Chuan He
Zhongyu Zou
In this issue, Cieśla et al.1 report a translation regulation through ALKBH5-mediated 5'-UTR m6A demethylation of the SF3B1 transcript during leukemic transformation. The SF3B1 protein maintains efficient splicing and expression of transcr...
Geraldine Seydoux,Mingjie Zhang,Julie D Forman-Kay et al.
Geraldine Seydoux et al.
As phase separation is found in an increasing variety of biological contexts, additional challenges have arisen in understanding the underlying principles of condensate formation and function. We spoke with researchers across disciplines ab...
Meet the author: Ling Wang [0.03%]
作者简介：王玲
Sonhita Chakraborty,Ling Wang
Sonhita Chakraborty
Ling Wang, first author of "Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination" in this issue of Molecular Cell, speaks about her motivations for becoming a scientist, the challenges she...
Xiao Li,Xiaona Tang,Xinyang Bing et al.
Xiao Li et al.
The impact of genome organization on the control of gene expression persists as a major challenge in regulatory biology. Most efforts have focused on the role of CTCF-enriched boundary elements and TADs, which enable long-range DNA-DNA asso...